Reactor design and selection for effective continuous manufacturing of pharmaceuticals [0.03%]
面向持续制造的药物反应器设计与选择
Chuntian Hu
Chuntian Hu
Pharmaceutical production remains one of the last industries that predominantly uses batch processes, which are inefficient and can cause drug shortages due to the long lead times or quality defects. Consequently, pharmaceutical companies a...
Timothy Noël
Timothy Noël
Design and application of a modular and scalable electrochemical flow microreactor [0.03%]
模块化和可扩展的电化学流动微反应器的设计与应用
Gabriele Laudadio,Wouter de Smet,Lisa Struik et al.
Gabriele Laudadio et al.
Electrochemistry constitutes a mild, green and versatile activation method of organic molecules. Despite these innate advantages, its widespread use in organic chemistry has been hampered due to technical limitations, such as mass and heat ...
An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2(1H)-ones [0.03%]
自动化顺序杂环/多组分反应的过程：连续流动合成5-（噻唑-2-基）-3,4-二氢嘧啶并-2（1H）-酮类化合物的多步法
Nicholas Pagano,Ananda Herath,Nicholas D P Cosford
Nicholas Pagano
The first example of a sequential heterocycle formation/multicomponent reaction using an automated continuous flow microreactor assembly is reported. Consecutive Hantzsch thiazole synthesis, deketalization, and Biginelli multicomponent reac...
Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS) [0.03%]
基于微波辅助连续流动有机合成（MACOS）的多功能流反应器：一步脱除和介元双aza-迈克尔加成参与的1,2,5-硫代二氮杂环己烷1,1-二氧化物类库合成
Farman Ullah,Qin Zang,Salim Javed et al.
Farman Ullah et al.
A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition stra...
Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out [0.03%]
通过微波增强型连续流动有机合成(MACOS)进行富立体化学的磺胺合成
Michael G Organ,Paul R Hanson,Alan Rolfe et al.
Michael G Organ et al.
The generation of stereochemically-rich benzothiaoxazepine-1,1'-dioxides for enrichment of high-throughput screening collections is reported. Utilizing a microwave-assisted, continuous flow organic synthesis platform (MACOS), scale-out of c...