Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank [0.03%]
加速生物老化与痴呆、认知功能和脑结构变化之间的关联：基于英国生物样本库的前瞻性队列研究
Xiaowei Zheng,Wenyang Han,Yiqun Li et al.
Xiaowei Zheng et al.
Background: Several small-sample studies have suggested that biological processes of ageing are implicated with dementia and cognitive function. We aimed to prospectively investigate the associations of biological age wit...
Efficacy and safety of Y-3 intracalvariosseous injection versus intravenous injection in the treatment of acute large hemispheric infarction (SOLUTION-2): rationale and design of a multicentre, prospective, randomised, open-label, blind endpoint (PROBE) trial [0.03%]
Y-3颅内注射联合静脉给药与单纯静脉给药治疗急性大半球卒中的疗效和安全性研究（解决方案-2）：前瞻性、多中心、开放标签假终点随机对照临床试验方案
Nanxing Wang,Meiyang Zhang,Mo Yang et al.
Nanxing Wang et al.
Rationale: The blood-brain barrier (BBB) largely restricts the efficacy of neuroprotectants, which is an important approach in treating large hemispheric infarction (LHI). In this study, we harnessed intracalvariosseous (...
Electroacupuncture reduces neuroinflammation and neuronal pyroptosis via downregulating Neat1 in rats after stroke [0.03%]
电针通过下调Neat1减少卒中大鼠神经炎症和神经元pyroptosis
Wanqing Lin,Zhaolian Cai,Xiaoyong Zhong et al.
Wanqing Lin et al.
Background: We investigated the potential contribution of the lncRNA Neat1 to the therapeutic efficacy of electroacupuncture (EA) after ischaemic stroke. ...
Role of histone deacetylases and sirtuins in the ischaemic stroke: a systematic review and meta-analysis of animal studies [0.03%]
组蛋白去乙酰化酶和沉默素在缺血性脑卒中中的作用：动物研究的系统评价和荟萃分析
Ali Majdi,Shahin Yaraghi,Ali Moharrami et al.
Ali Majdi et al.
Background: Treatment of ischaemic stroke requires exploration of novel neuroprotective strategies owing to the constraints of thrombolytic therapy. Recent research implies that modulation of histone deacetylases (HDAC) o...
Yi Dong,Lu Xu,Lan Hong et al.
Yi Dong et al.
Effectiveness of intravenous recombinant plasminogen activator treatment in Chinese patients with acute ischaemic stroke aged over 80 years: a retrospective cohort study [0.03%]
重组组织型纤溶酶原激活剂治疗中国大于80岁急性缺血性卒中患者的有效性：队列研究
Jiansheng Yang,Yu-Hui Huang,Wansi Zhong et al.
Jiansheng Yang et al.
Background: Risks and benefits of intravenous recombinant tissue plasminogen activator (rt-PA) remain unclear among elderly patients with acute ischaemic stroke (AIS). This study investigated 1-year clinical outcomes of i...
Comparing the effectiveness and safety of rescue balloon angioplasty versus stenting in acute large vessel occlusion after thrombectomy [0.03%]
比较急性大血管闭塞取栓后的救兵球囊成形术与支架置入疗效和安全性的研究
Yu Jiang,Chao Li,Mingchao Shi et al.
Yu Jiang et al.
Background: Intracranial atherosclerotic stenosis (ICAS) is a leading cause of failed mechanical thrombectomy (MT). To achieve successful recanalisation, rescue strategies such as balloon angioplasty and stenting are freq...
Predicting clinical outcome in posterior circulation large-vessel occlusion patients with endovascular recanalisation: the GNC score [0.03%]
后循环大血管闭塞患者血管内再通的临床预后预测：GNC评分
Jia-Qi Wang,Si-Qi Qiu,Wei Li et al.
Jia-Qi Wang et al.
Background and purpose: Acute ischaemic strokes caused by posterior circulation large-vessel occlusions (pc-LVOs) are associated with particularly poor prognoses, including significant disability and mortality rates. This...
Prognostic significance of contrast staining following mechanical thrombectomy in acute ischaemic stroke [0.03%]
急性缺血性卒中机械取栓术后对比剂残留的预后价值
Jing Yan,Xiang Xu,Haiyan Li et al.
Jing Yan et al.
Background: Advances in endovascular thrombectomy (EVT) and extended treatment criteria have improved outcomes in acute ischaemic stroke (AIS). However, contrast staining (CS) on postoperative CT complicates clinical deci...
Impact of socioeconomic deprivation on mechanical thrombectomy outcomes after acute ischaemic stroke: findings from a London-based multicentre study [0.03%]
社会经济剥夺对急性缺血性卒中机械取栓结局影响的伦敦多中心研究发现
Lucio D&#x;Anna,Soma Banerjee,Viva Levee et al.
Lucio D&#x;Anna et al.
Background: Mechanical thrombectomy (MT) improves outcomes in patients who had an acute ischaemic stroke due to large vessel occlusion (LVO). However, socioeconomic status (SES) can influence recovery and prognosis. This ...