Treatment of acute intracerebral haemorrhage with a Chinese herbal formula (Shengdi Dahuang Decoction): a multicentre, double-blind, randomised, placebo-controlled trial [0.03%]
中药生地大黄汤治疗急性脑出血的多中心随机双盲安慰剂对照试验
Zhihuan Sun,Xiaoyu Zhou,Jingyan Xiang et al.
Zhihuan Sun et al.
Importance: Per preliminary studies, Shengdi Dahuang Decoction (SDD) is potentially effective for acute intracerebral haemorrhage (ICH); however, its effectiveness has not been rigorously assessed in extensive randomised ...
Association of fluid balance with 3-month outcomes in severe acute ischaemic stroke [0.03%]
急性重度脑梗死患者液体平衡与3个月预后之间的关系
Meng Liu,Yanan Wang,Xing Hua et al.
Meng Liu et al.
Background: Fluid therapy is commonly used for patients with severe stroke, for whom fluid balance is a safety endpoint for evaluating the therapy. We aimed to investigate the association of fluid balance with 3-month out...
Where are we going for the treatment in ischaemic stroke: a comprehensive study of investigator-sponsored randomised controlled trials, 1990-2024 [0.03%]
缺血性卒中治疗研究目的地：一项关于研究者发起的随机对照试验（1990-2024）的全面分析
Xinya Li,Xue Xia,Meng Gao et al.
Xinya Li et al.
Background: Until recently, a comprehensive understanding of the current development status and emerging trends of investigator-sponsored randomised controlled trials (RCTs) for the treatment of ischaemic stroke (IS) on a...
Altered gut microbiota and short-chain fatty acid in acute ischaemic stroke with active cancer [0.03%]
急性缺血性卒中伴发活动期癌症患者的肠道菌群及短链脂肪酸变化研究
Wei Song,Xiaofei Lin,Genghong Xia et al.
Wei Song et al.
Background: Acute ischaemic stroke (AIS) in patients with active cancer presents unique etiological factors and correlates with worse outcomes. Although gut microbiota dysbiosis has been separately documented in stroke pa...
Rationale and design of Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined with Endovascular Treatment in ACute Ischaemic StrokE (RETRACE II): a randomised double-blind controlled multicentre phase II pilot study [0.03%]
低频重复经颅磁刺激联合急性缺血性卒中血管内治疗（RETRACE II）研究方案及设计：一项随机双盲对照多中心Ⅱ期试点临床试验
Lingling Ding,Wenjie Wang,Tingyu Yi et al.
Lingling Ding et al.
Background: While endovascular therapy (EVT) remains the primary treatment for acute ischaemic stroke (AIS) management, persistent functional deficits in patients with successful recanalisation underscore the necessity fo...
Multiomics genetic insights into potential molecular targets for intracranial aneurysm [0.03%]
多组学基因见解揭示颅内动脉瘤潜在分子靶点
Yitong Jia,Fa Lin,Runting Li et al.
Yitong Jia et al.
Background: This study aimed to identify multiomics therapeutic targets for aneurysmal subarachnoid haemorrhage (aSAH) and unruptured intracranial aneurysm (uIA) using Mendelian randomisation (MR), summary-data-based MR (...
Predictors of futile recanalisation in patients with large infarct: a post-hoc analysis of the ANGEL-ASPECT trial [0.03%]
大梗死患者无益再通的预测因素：来自ANGEL-ASPECT试验的事后分析
Tingyu Yi,Xiaochuan Huo,Xiaohui Lin et al.
Tingyu Yi et al.
Background: Studies on futile recanalisation after endovascular therapy (EVT) for anterior circulation large vessel occlusion with large infarct were scarce. The present study aimed to explore the incidence and independen...
Prevalence of depression and cognitive impairment and their inter-relationship and association with quality of life among older stroke survivors: the findings of a national survey in China [0.03%]
中国老年人卒中后抑郁和认知障碍的流行病学特征及相互作用：一项全国调查结果
Mu-Rui Zheng,Pan Chen,Yuan Feng et al.
Mu-Rui Zheng et al.
Background: Post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI) are prevalent neuropsychiatric problems that are associated with high disability burden and low quality of life (QoL). This study explor...
Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke [0.03%]
遗传预测的白质微结构介导了危险因素和腔隙性卒中的关系
Jie Zhang,Min Wu,Douglas Neville et al.
Jie Zhang et al.
Background and purpose: Lacunar stroke is a complex, multifactorial disease with significant genetic underpinnings. However, the mechanisms through which genetic predispositions and risk factors contribute to its pathogen...
Vascular β-amyloid potentially colocalises with phosphorylated tau in cerebral amyloid angiopathy [0.03%]
血管性β淀粉样蛋白可能与脑淀粉样血管病中的磷酸化tau共定位
Hsin-Hsi Tsai,Bo-Ching Lee,Chia-Ju Liu et al.
Hsin-Hsi Tsai et al.
Background: Tau pathology is observed in cerebral amyloid angiopathy (CAA) and is related to cognitive impairment and neurodegeneration. However, the relationship between tau pathology and amyloid accumulation in the vasc...