Standardising the diagnosis and imaging of intracranial atherosclerotic stenosis in Asia: a call for regional consensus [0.03%]
亚洲颅内动脉粥样硬化性狭窄诊断和影像学共识地区标准的倡议
Jose C Navarro,Bonifacio C Pedregosa,Maria Socorro F Sarfati et al.
Jose C Navarro et al.
Intravenous thrombolysis versus early antiplatelet therapy in acute ischaemic stroke with small artery occlusion [0.03%]
急性小动脉闭塞缺血性卒中的静脉溶栓与早期抗血小板治疗对比研究
Ke Zhang,Hongbing Liu,Ce Zong et al.
Ke Zhang et al.
Background: The efficacy of intravenous thrombolysis (IVT) versus early antiplatelet therapy (APT) in small artery occlusion (SAO) stroke remains debated. ...
Macular choriocapillaris perfusion area: a potential biomarker of mild cognitive impairment in patients with cerebral small vessel disease [0.03%]
脉络膜毛细血管灌注面积：脑小血管病伴轻度认知障碍患者的潜在生物标志物
Weitao Yu,Zeqi Shen,Weifen Zhang et al.
Weitao Yu et al.
Aim: To develop and validate retinal vascular biomarkers for detecting mild cognitive impairment (MCI) in cerebral small vessel disease (CSVD) using swept-source optical coherence tomography angiography (SS-OCTA). ...
Phase I dose-escalation study of tenecteplase, a third-generation fibrinolytic agent, combined with neuronavigation-assisted stereotactic minimally invasive puncture, in patients with acute spontaneous deep cerebral haemorrhage [0.03%]
重组第三代纤维蛋白溶解剂替奈普酶联合神经导航定位微创穿刺技术治疗急性自发性脑深部出血剂量递增临床I期研究
Zhiyou Wu,Mingze Wang,Xiudan Bai et al.
Zhiyou Wu et al.
Introduction: Tenecteplase (TNK) offers logistical advantages in stroke thrombolytic therapy with its single bolus administration compared with alteplase. Moreover, its high specificity for fibrin may contribute to a redu...
Dual versus mono antiplatelet therapy within 72 hours after onset for mild ischaemic stroke or transient ischaemic attack: meta-analysis of randomised controlled trials [0.03%]
轻型缺血性卒中或短暂性脑缺血发作发病72小时内双联抗血小板治疗与单用抗血小板治疗的对照研究的Meta分析
Yingying Yang,Jinghan Zhu,Ying Gao et al.
Yingying Yang et al.
Background: Although previous evidence generally agreed on the short-term dual antiplatelet therapy (DAPT) for mild stroke or transient ischaemic attack (TIA), there is no consensus on the optimal threshold for stroke sev...
Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis [0.03%]
颅内动脉狭窄人群脑小血管病相关脑结构损害特点
Zi-Ang Pan,Zi-Yue Liu,Xing-Qi Pan et al.
Zi-Ang Pan et al.
Background and aims: Covert MRI markers of cerebral small vessel disease (CSVD) can coexist with large artery atherosclerosis. We aimed to explore whether the spatial distributions of these markers were diverse in people ...
Brain-targeted extracellular vesicles for anti-cuproptosis therapy in subarachnoid haemorrhage [0.03%]
针对蛛网膜下腔出血的脑靶向细胞外囊泡抗铜死亡治疗
Pengcheng Xu,Jian Fang,Feiyun Qin et al.
Pengcheng Xu et al.
Background: Subarachnoid haemorrhage (SAH) is primarily caused by ruptured aneurysms with high mortality worldwide. Cuproptosis is a copper-induced cell death that regulates lipoylated tricarboxylic acid cycle proteins. T...
BEST-BAO: a multicentre, prospective, randomised controlled trial of endovascular treatment with or without intravenous thrombolysis in acute ischaemic stroke due to basilar artery occlusion - study protocol and rationale [0.03%]
最佳取栓研究（BEST-BAO）：基底动脉闭塞急性缺血性卒中血管内治疗的多中心前瞻性随机对照临床试验——方案与依据
Yang Xiang,Shu Yang,Lei Guo et al.
Yang Xiang et al.
Background: Endovascular treatment (EVT) is safe and effective in treating acute ischaemic stroke due to basilar artery occlusion (AIS-BAO); nonetheless, the impact of intravenous thrombolysis (IVT) on its efficacy remain...
Tongxinluo capsule in the treatment of cerebral small vessel disease: protocol of a randomised, double-blind, placebo-controlled, multicentre clinical study (TOPS-CSVD) [0.03%]
通心络胶囊治疗脑小血管病的临床研究方案：一项随机、双盲、安慰剂对照、多中心临床试验(TOPS-CSVD)
Yingzhe Wang,Xiaodi Xie,Jun Xu et al.
Yingzhe Wang et al.
Background: Tongxinluo capsule has demonstrated multiple beneficial effects on microcirculation, endothelial cells and inflammation. However, evidence supporting their efficacy in improving vascular cognitive decline is l...
Incidence and impact of brain lesions and cognitive impairment after CABG with moderate or severe cerebral artery stenosis seen on low-field MRI [0.03%]
低场磁共振成像显示中重度脑动脉狭窄患者的冠状动脉旁路移植术后脑梗死和认知功能障碍的发病率及影响
Guitao Zhang,Yingjian Pei,Fei Xu et al.
Guitao Zhang et al.
Objective: The study aimed to assess the incidence and impact of brain lesions and cognitive impairment after coronary artery bypass grafting (CABG) in patients with moderate-to-severe cerebral artery stenosis using low-f...