Efficacy and safety of stem cell therapy in ischemic stroke patients: a systematic review and meta-analysis of randomised controlled trials [0.03%]
缺血性卒中患者干细胞治疗的有效性和安全性：随机对照试验的系统评价和.meta.分析
Daniel de Wilde,Attill Saemann,Raphael Guzman
Daniel de Wilde
Background: Stem cell (SC) transplantation is a promising therapeutic approach for ischemic stroke (IS). However, the current literature lacks robust evidence substantiating its efficacy and safety. This systematic review...
Framework for developing intracerebral haemorrhage recognition scales and technologies for hyperacute prehospital blood pressure lowering [0.03%]
脑出血识别评分和超早期院前降压技术框架
Shayandokht Taleb,Jamie Hsu,Jeffrey L Saver
Shayandokht Taleb
Background: Hyperacute prehospital blood pressure (BP)-lowering in randomised trial setting improves outcomes for intracerebral haemorrhage (ICH) but worsens outcomes for acute cerebral ischaemia. Consequently, hyperacute...
Machine learning models for predicting futile recanalisation after endovascular treatment in patients with large core infarction [0.03%]
机器学习模型预测大梗死核心患者血管内治疗后无效再通的效果
Yawen Gan,Shuang Song,Dingwen Zhang et al.
Yawen Gan et al.
Background: Predicting futile recanalisation following endovascular treatment (EVT) in patients with large core infarctions is crucial for guiding clinical decisions, optimising perioperative management and improving heal...
Rationale and design of Ticagrelor with Aspirin Dual Antiplatelet Therapy Combined with Intravenous Thrombolysis in Patients with Ischemic Stroke (TAPIS): a multicentre, randomised, double-blind, parallel group, placebo-controlled trial [0.03%]
替格瑞洛联合阿司匹林双通道抗血小板治疗联合静脉溶栓治疗缺血性卒中的合理性和设计：一项多中心、随机、双盲、平行分组、安慰剂对照试验(TAPIS)
Anxin Wang,Xue Xia,Philip M Bath et al.
Anxin Wang et al.
Background and purpose: Evidence on whether add-on early antiplatelet therapy may improve functional outcome in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) remains inconsistent. This ...
Factors associated with infarct volume growth after mechanical thrombectomy in large core infarction: ANGEL-ASPECT insights [0.03%]
ANGEL-ASPECT研究中大梗死核心患者机械取栓后梗死体积扩大的相关因素分析
Longhui Zhang,Yufan Liu,Fangguang Chen et al.
Longhui Zhang et al.
Background: Infarct volume growth (IVG) correlates with outcomes and may represent a prognostic imaging biomarker in acute ischaemic stroke due to anterior circulation large vessel occlusion (LVO). This study aims to iden...
30 years of thrombolysis for ischaemic stroke: expanded agents, widened windows and accelerated delivery [0.03%]
溶栓治疗缺血性卒中的30年：药物扩大、时间窗延长以及加速给药
Bowei Zhang,Shuya Li,Xia Meng et al.
Bowei Zhang et al.
Over the past three decades, thrombolytic therapy for acute ischaemic stroke has evolved dramatically since the landmark National Institute of Neurological Disorders and Stroke (NINDS) trial in 1995, which formally established recombinant t...
Heterogeneity of cerebral small vessel disease based on imaging markers in a community-based population [0.03%]
基于影像标志物的社区人群中脑小血管疾病的异质性研究
Yuxian Li,Dandan Liu,Yingying Yang et al.
Yuxian Li et al.
Background: The heterogeneity of cerebral small vessel disease (CSVD) within community populations remains underexplored. In this study, we aimed to establish an imaging biomarker-based research paradigm to investigate CS...
Mechanisms of disorders of consciousness based on source-level microstate characteristics under deep brain stimulation neuromodulation [0.03%]
深脑刺激神经调控下基于源水平微状态特征的意识障碍机制研究
Tianqing Cao,Yihua Wang,Bin Jiang et al.
Tianqing Cao et al.
Background: Improving the efficacy of neuroregulatory treatments for disorders of consciousness (DOCs) remains a significant challenge. Changes in brain spatiotemporal dynamics reveal the underlying mechanisms of brain ne...
RIC-specific cytoprotective profile mediated by microglia in a mouse model of acute ischaemic stroke [0.03%]
小鼠急性缺血性卒中模型中微胶质细胞介导的RIC特异性细胞保护表型研究
Coral Torres-Querol,Gloria Arqué,Francisco Purroy
Coral Torres-Querol
Background: Remote ischaemic conditioning (RIC) is an endogenous neuroprotective strategy involving repeated, transient occlusion of a limb artery to reduce ischaemic injury at a distant site. We investigated the effects ...
Yongjun Wang,Bowei Zhang,Xuewei Xie
Yongjun Wang
Over the past three decades, the development of evidence-based medicine (EBM) has brought significant opportunities to the advancement of clinical practice in stroke medicine. Substantial EBM evidence has transformed clinical practice in mu...