Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies [0.03%]
甘氨酸能传递：神经病理中的甘氨酸转运蛋白GlyT2作用
Francisco Zafra,Ignacio Ibáñez,Cecilio Giménez
Francisco Zafra
Glycinergic neurons are major contributors to the regulation of neuronal excitability, mainly in caudal areas of the nervous system. These neurons control fluxes of sensory information between the periphery and the CNS and diverse motor act...
Amrita Pathak,Bruce D Carter
Amrita Pathak
Neurotrophins are target-derived factors necessary for mammalian nervous system development and maintenance. They are typically produced by neuronal target tissues and interact with their receptors at axonal endings. Therefore, locally gene...
Norbert Weiss,Gerald W Zamponi
Norbert Weiss
Neuronal voltage-gated calcium channels (VGCCs) serve complex yet essential physiological functions via their pivotal role in translating electrical signals into intracellular calcium elevations and associated downstream signalling pathways...
Theodora Kalpachidou,Kai K Kummer,Michaela Kress
Theodora Kalpachidou
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain in general, and members of the non-coding RNA (ncRNA) family, specifically the short, 22 nucleotide microRNAs (miRNAs) ...
The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells [0.03%]
孤儿核受体TLX：小胶质细胞与神经前体细胞之间串扰的新兴主调节因子
Paul J Lucassen,Anne-Marie van Dam,Prasanna Kandel et al.
Paul J Lucassen et al.
Neuroinflammation and neurogenesis have both been the subject of intensive investigation over the past 20 years. The sheer complexity of their regulation and their ubiquity in various states of health and disease have sometimes obscured the...
Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer's disease [0.03%]
脑中的氧化胆固醇分子：糖尿病和阿尔兹海默病
Thaddeus K Weigel,Joshua A Kulas,Heather A Ferris
Thaddeus K Weigel
Type 2 diabetes is associated with adverse central nervous system effects, including a doubled risk for Alzheimer's disease (AD) and increased risk of cognitive impairment, but the mechanisms connecting diabetes to cognitive decline and dem...
Sophie M Hapak,Carla V Rothlin,Sourav Ghosh
Sophie M Hapak
The atypical Protein Kinase Cs (aPKCs)-PRKCI, PRKCZ and PKMζ-form a subfamily within the Protein Kinase C (PKC) family. These kinases are expressed in the nervous system, including during its development and in adulthood. One of the aPKCs,...
Autophagy in the mammalian nervous system: a primer for neuroscientists [0.03%]
自噬在哺乳动物神经系统中的作用：神经科学入门指南
Fumi Suomi,Thomas G McWilliams
Fumi Suomi
Autophagy refers to the lysosomal degradation of damaged or superfluous components and is essential for metabolic plasticity and tissue integrity. This evolutionarily conserved process is particularly vital to mammalian post-mitotic cells s...
Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease [0.03%]
通过(S)-拉考沙胺调节CRMP2表现出治疗前景，但在CLN6儿童失聪症小鼠模型中最终无效
Katherine A White,Jacob T Cain,Helen Magee et al.
Katherine A White et al.
CLN6-Batten disease is a rare neurodegenerative disorder with no cure, characterized by accumulation of lipofuscin in the lysosome, glial activation, and neuronal death. Here we test the therapeutic efficacy of modulating collapsin response...
The role of APOE4 in Alzheimer's disease: strategies for future therapeutic interventions [0.03%]
APOE4在阿尔茨海默病中的作用及未来治疗策略
Holly C Hunsberger,Priyanka D Pinky,Warren Smith et al.
Holly C Hunsberger et al.
Alzheimer's disease (AD) is the leading cause of dementia affecting almost 50 million people worldwide. The ε4 allele of Apolipoprotein E (APOE) is the strongest known genetic risk factor for late-onset AD cases, with homozygous APOE4 carr...