Neural mechanisms of dopamine function in learning and memory in Caenorhabditis elegans [0.03%]
神经机制在学习和记忆中的多巴胺功能在秀丽隐杆线虫中的作用
Anna McMillen,Yee Lian Chew
Anna McMillen
Research into learning and memory over the past decades has revealed key neurotransmitters that regulate these processes, many of which are evolutionarily conserved across diverse species. The monoamine neurotransmitter dopamine is one exam...
Modelling Alzheimer's disease in a dish: dissecting amyloid-β metabolism in human neurons [0.03%]
在盘子中模拟阿尔茨海默病：解析人类神经元中的淀粉样蛋白-β代谢过程
Elizabeth Hill,Thomas J Cunningham
Elizabeth Hill
This scientific commentary refers to 'Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition' by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have b...
Nicolas Dzamko
Nicolas Dzamko
The contribution of the immune system to the pathophysiology of neurodegenerative Parkinson's disease (PD) is increasingly being recognised, with alterations in the innate and adaptive arms of the immune system underlying central and periph...
Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders [0.03%]
炎症与情绪调节：情感失调障碍中的证据和机制的叙述性综述
Flavia Petruso,Alexis E Giff,Beatrice A Milano et al.
Flavia Petruso et al.
Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well as when and how these emotions are experienced or expressed. It is a focal overarching symptom in many severe and prevalent neuropsych...
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition [0.03%]
人源化神经元中胰岛素降解酶的抑制促进淀粉样蛋白沉积
Helen A Rowland,Samuel R Moxon,Nicola J Corbett et al.
Helen A Rowland et al.
Alzheimer's disease (AD) is characterised by the aggregation and deposition of amyloid-β (Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation and clearance, rather than enhanced production, of Aβ contribu...
Chiara Domenicale,Stefano Magnabosco,Michele Morari
Chiara Domenicale
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson's disease (PD). Sporadic PD and LRRK2 PD share main clinical and neuropathological features, namely hypokinesia, degener...
Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders [0.03%]
应激相关疾病中的内源大麻素信号与表观遗传修饰的作用
Arthur A Coelho,Sávio Lima-Bastos,Pedro H Gobira et al.
Arthur A Coelho et al.
Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or reinstating substance use disorder. Stress causes several ...
Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin [0.03%]
抑郁症发病机制中的炎症反应：神经免疫系统紊乱所致
Myles Corrigan,Aoife M O&#x;Rourke,Barry Moran et al.
Myles Corrigan et al.
There are several hypotheses concerning the underlying pathophysiological mechanisms of major depression, which centre largely around adaptive changes in neuronal transmission and plasticity, neurogenesis, and circuit and regional connectiv...
Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders [0.03%]
母体免疫激活及胎盘作用于产前编程神经发育障碍疾病的机制研究
Rebecca M Woods,Jarred M Lorusso,Jennifer Fletcher et al.
Rebecca M Woods et al.
Maternal infection during pregnancy, leading to maternal immune activation (mIA) and cytokine release, increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. Animal models have ...
Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression [0.03%]
父辈早期生活压力对C57BL/6J小鼠子代冒险行为及天敌气味诱导的c-fos表达的影响
Ulysse M C C Thivisol,Phoebe Ho,Baijia Li et al.
Ulysse M C C Thivisol et al.
Paternal preconceptional health factors, such as exposures to stress, diet and exercise, have been found to significantly influence offspring phenotypes in a range of animal models. Preclinical studies have provided evidence that paternal s...