Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists? [0.03%]
抑郁症中阿片受体信号传导的研究：我们是否需要选择性的κ阿片受体拮抗剂？
Sarah J Bailey,Stephen M Husbands
Sarah J Bailey
The opioid receptors are a family of G-protein coupled receptors (GPCRs) with close structural homology. The opioid receptors are activated by a variety of endogenous opioid neuropeptides, principally β-endorphin, dynorphins, leu- and met-...
Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson's disease [0.03%]
miR-181a抑制通过Smad1/5依赖性机制促进中脑神经生长：帕金森病的治疗意义
Shane V Hegarty,Aideen M Sullivan,Gerard W O&#x;Keeffe
Shane V Hegarty
Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Current PD treatments are symptomatic, wear off over time and do ...
Cross-talk between blood vessels and neural progenitors in the developing brain [0.03%]
发育中大脑内血管与神经前体细胞的相互作用
Mathew Tata,Christiana Ruhrberg
Mathew Tata
The formation of the central nervous system (CNS) involves multiple cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels to establish extensive and complex neural networks and attract a vascular suppl...
Extracellular microRNAs as messengers in the central and peripheral nervous system [0.03%]
细胞外microRNA作为中枢和外周神经系统的信使
Hannah Scott
Hannah Scott
MicroRNAs are small post-transcriptional regulators that play an important role in nervous system development, function and disease. More recently, microRNAs have been detected extracellularly and circulating in blood and other body fluids,...
Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review [0.03%]
影响AMPA和NMDA突触反应变异性的随机、结构和功能因素：综述
Vito Di Maio,Francesco Ventriglia,Silvia Santillo
Vito Di Maio
Synaptic transmission is the basic mechanism of information transfer between neurons not only in the brain, but along all the nervous system. In this review we will briefly summarize some of the main parameters that produce stochastic varia...
SUMOylation and calcium signalling: potential roles in the brain and beyond [0.03%]
SUMO化与钙信号：在大脑及其他领域的潜在作用
Leticia Coelho-Silva,Gary J Stephens,Helena Cimarosti
Leticia Coelho-Silva
Small ubiquitin-like modifier (SUMO) conjugation (or SUMOylation) is a post-translational protein modification implicated in alterations to protein expression, localization and function. Despite a number of nuclear roles for SUMO being well...
Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease [0.03%]
靶向骨形态生成蛋白信号通路作为帕金森病多巴胺能神经元的治疗途径
Gerard W O&#x;Keeffe,Shane V Hegarty,Aideen M Sullivan
Gerard W O&#x;Keeffe
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by the degeneration of midbrain dopaminergic (mDA) neurons and their axons, and aggregation of α-synuclein, which leads to motor and late-stage cog...
Claire Thornton
Claire Thornton
Metabolically energetic organs, such as the brain, require a reliable source of ATP, the majority of which is provided by oxidative phosphorylation in the mitochondrial matrix. Maintaining mitochondrial integrity is therefore of paramount i...
Julia A Callender,Alexandra C Newton
Julia A Callender
Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids. While PKC has been widely implicated in the pathology of dis...
Aideen M Sullivan
Aideen M Sullivan
There have been a number of advances in our knowledge of neuronal communication in processes involved in development, functioning and disorders of the nervous system. This progress has prompted the Biochemical Society to launch Neuronal Sig...