Fei Gao,Jianmin Zhang
Fei Gao
Mitochondria homeostasis is sustained by the mitochondrial quality control (MQC) system, which is crucial for cellular health, especially in the maintenance of functional mitochondria. A healthy mitochondria network is essential for life as...
Elena Britti,Fabien Delaspre,Jordi Tamarit et al.
Elena Britti et al.
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meani...
Role of frataxin protein deficiency and metabolic dysfunction in Friedreich ataxia, an autosomal recessive mitochondrial disease [0.03%]
弗里德赖希共济失调中脆性X染色体E基因蛋白缺乏和代谢功能障碍的作用是一项关于常染色体隐性遗传的线粒体疾病的研 Fresno 医学研究论文奖获奖论文
Elisia Clark,Joseph Johnson,Yi Na Dong et al.
Elisia Clark et al.
Friedreich ataxia (FRDA) is a progressive neurodegenerative disease with developmental features caused by a genetic deficiency of frataxin, a small, nuclear-encoded mitochondrial protein. Frataxin deficiency leads to impairment of iron-sulp...
Physiological and pathological functions of LRRK2: implications from substrate proteins [0.03%]
LRRK2底物蛋白的发现对理解其生理和病理功能的意义
Miho Araki,Genta Ito,Taisuke Tomita
Miho Araki
Leucine-rich repeat kinase 2 (LRRK2) encodes a 2527-amino acid (aa) protein composed of multiple functional domains, including a Ras of complex proteins (ROC)-type GTP-binding domain, a carboxyl terminal of ROC (COR) domain, a serine/threon...
Potential for endocannabinoid system modulation in ocular pain and inflammation: filling the gaps in current pharmacological options [0.03%]
眼痛和炎症中内源大麻素系统调节的潜在作用：填补当前药理学选择的空白
J Daniel Lafreniere,Melanie E M Kelly
J Daniel Lafreniere
Challenges in the management of ocular pain are an underappreciated topic. Currently available therapeutics lack both efficacy and clear guidelines for their use, with many also possessing unacceptable side effects. Promising novel agents w...
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome [0.03%]
TAF1的新变异影响基因表达并与X染色体连锁的TAF1智力残疾综合征相关
Sarah E Hurst,Erika Liktor-Busa,Aubin Moutal et al.
Sarah E Hurst et al.
We investigated the genome of a 5-year-old male who presented with global developmental delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia of unknown origin. Whole genome sequencing (WGS) and mRNA se...
Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats [0.03%]
围产期注射苯环利定致大鼠青春期和成年海马LINGO-1信号分子表达异常
Jessica L Andrews,Kelly A Newell,Natalie Matosin et al.
Jessica L Andrews et al.
Postnatal administration of phencyclidine (PCP) in rodents causes major brain dysfunction leading to severe disturbances in behavior lasting into adulthood. This model is routinely employed to model psychiatric disorders such as schizophren...
Raj Kumar
Raj Kumar
Botulinum toxin is one of the most potent molecule known to mankind. A neurotoxin, with high affinity for cholinergic synapse, is effectively capable of inhibiting the release of acetylcholine. On the other hand, botulinum toxin is therapeu...
Paul W Young
Paul W Young
Ligand of NUMB Protein X1 and X2 (LNX1 and LNX2) are E3 ubiquitin ligases, named for their ability to interact with and promote the degradation of the cell fate determinant protein NUMB. On this basis they are thought to play a role in modu...
Laura K Olsen,Eilis Dowd,Declan P McKernan
Laura K Olsen
Despite over 200 years since its first description by James Parkinson, the cause(s) of most cases of Parkinson's disease (PD) are yet to be elucidated. The disparity between the current understanding of PD symptomology and pathology has led...