MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment [0.03%]
早期环境富集通过MEF2C和HDAC5调节Egr1和Arc基因来增加树突棘的密度和复杂度
Shu Juan Puang,Bavani Elanggovan,Tendy Ching et al.
Shu Juan Puang et al.
We investigated the effects of environmental enrichment during critical period of early postnatal life and how it interplays with the epigenome to affect experience-dependent visual cortical plasticity. Mice raised in an EE from birth to du...
Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function [0.03%]
线粒体定位及动态变化在神经元功能中的机制和作用
Richard Seager,Laura Lee,Jeremy M Henley et al.
Richard Seager et al.
Neurons are highly polarised, complex and incredibly energy intensive cells, and their demand for ATP during neuronal transmission is primarily met by oxidative phosphorylation by mitochondria. Thus, maintaining the health and efficient fun...
A role for TGFβ signalling in medium spiny neuron differentiation of human pluripotent stem cells [0.03%]
TGFβ信号在人多能干细胞向中脊神经元分化中的作用
Marija Fjodorova,Zoe Noakes,Meng Li
Marija Fjodorova
Activin A and other TGFβ family members have been shown to exhibit a certain degree of promiscuity between their family of receptors. We previously developed an efficient differentiation protocol using Activin A to obtain medium spiny neur...
The class II histone deacetylases as therapeutic targets for Parkinson's disease [0.03%]
组蛋白脱乙酰酶2类作为帕金森病的治疗靶点
Martina Mazzocchi,Louise M Collins,Aideen M Sullivan et al.
Martina Mazzocchi et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by specific motor impairments. The neuropathological hallmarks of PD include progressive degeneration of midbrain dopaminergic neurons, and loss of their axo...
Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma [0.03%]
骨形态生成蛋白受体与神经母细胞瘤的分子通路和生存结果之间的关联性研究
Amnah M Alshangiti,Sean L Wyatt,Erin McCarthy et al.
Amnah M Alshangiti et al.
Neuroblastoma (NB) is a paediatric cancer that arises in the sympathetic nervous system. Patients with stage 4 tumours have poor outcomes and 20% of high-risk cases have MYCN amplification. The bone morphogenetic proteins (BMPs) play roles ...
Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation [0.03%]
低氧条件下从胎盘屏障模型释放的骨形态发生蛋白等因子可改变皮质细胞
Veronica H L Leinster,Thomas J Phillips,Nicola Jones et al.
Veronica H L Leinster et al.
Episodes of hypoxia and hypoxia/reoxygenation during foetal development have been associated with increased risk of neurodevelopmental conditions presenting in later life. The mechanism for this is not understood; however, several authors h...
Madhusmita Priyadarshini Sahu,Outi Nikkilä,Seija Lågas et al.
Madhusmita Priyadarshini Sahu et al.
Primary neurons from rodent brain hippocampus and cortex have served as important tools in biomedical research over the years. However, protocols for the preparation of primary neurons vary, which often lead to conflicting results. This rep...
5-HT2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression [0.03%]
5-ht2a受体敲除不影响氟西汀急性诱发的焦虑行为且皮层即刻早期基因表达调控具有性别差异性
Minal Jaggar,Toshali Banerjee,Noelia Weisstaub et al.
Minal Jaggar et al.
Background: Acute treatment with the selective serotonin reuptake inhibitor (SSRI), fluoxetine (Flx), induces anxiety-like behavioral effects. The serotonin2A receptor (5-HT2A) is implicated in the modulation of anxiety-like behavior, howev...
Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease [0.03%]
子痫前期胎盘释放损害神经元的因子：对疾病胎儿编程的启示
Hannah Scott,Tom J Phillips,Greer C Stuart et al.
Hannah Scott et al.
Prenatal development is a critical period for programming of neurological disease. Preeclampsia, a pregnancy complication involving oxidative stress in the placenta, has been associated with long-term health implications for the child, incl...
Label-free imaging of neurotransmitters in live brain tissue by multi-photon ultraviolet microscopy [0.03%]
多光子紫外成像无标记实时观测脑组织内神经递质分布及变化规律
Barun Kumar Maity,Sudipta Maiti
Barun Kumar Maity
Visualizing small biomolecules in living cells remains a difficult challenge. Neurotransmitters provide one of the most frustrating examples of this difficulty, as our understanding of signaling in the brain critically depends on our abilit...