Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions [0.03%]
弗里德赖希共济病的线粒体和代谢功能障碍：病理生理学相关性和临床干预的最新研究进展
David R Lynch,Garrett Farmer
David R Lynch
Friedreich ataxia (FRDA) is a recessive disorder resulting from relative deficiency of the mitochondrial protein frataxin. Frataxin functions in the process of iron-sulfur (Fe-S) cluster synthesis. In this review, we update some of the proc...
Back to the future: lessons from past viral infections and the link with Parkinson's disease [0.03%]
返古通今：过去病毒感染的教训及其与帕金森病的关系
Eilis Dowd,Declan P McKernan
Eilis Dowd
During the current coronavirus disease 2019 (COVID-19) pandemic, there has been noticeable increase in the reporting of neurological symptoms in patients. There is still uncertainty around the significance and long-term consequence of these...
Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome [0.03%]
唐氏综合征Ts65Dn鼠模型中学习记忆缺陷相关信号通路的研究
Aimée Freeburn,Robert Gordon Keith Munn
Aimée Freeburn
Down syndrome (DS) is a genetic trisomic disorder that produces life-long changes in physiology and cognition. Many of the changes in learning and memory seen in DS are reminiscent of disorders involving the hippocampal/entorhinal circuit. ...
The life cycle of voltage-gated Ca2+ channels in neurons: an update on the trafficking of neuronal calcium channels [0.03%]
神经元电压门控Ca2+通道的生命历程——神经元钙通道转运的最新研究进展
Laurent Ferron,Saloni Koshti,Gerald W Zamponi
Laurent Ferron
Neuronal voltage-gated Ca2+ (CaV) channels play a critical role in cellular excitability, synaptic transmission, excitation-transcription coupling and activation of intracellular signaling pathways. CaV channels are multiprotein complexes a...
Neuronal Signaling: A reflection on the Biochemical Society's newest journal and an exciting outlook on its next steps [0.03%]
神经信号转导：Biochemical Society最新期刊《神经信号转导》的回顾及其未来发展方向的展望
Aideen M Sullivan,S Clare Stanford
Aideen M Sullivan
The inaugural Editor-in-Chief of Neuronal Signaling, Aideen M. Sullivan, reflects on the journal's journey so far and welcomes the new Editor-in-Chief, Clare Stanford, as she shares some of the exciting initiatives and plans for its future....
Yuki Fujita,Toshihide Yamashita
Yuki Fujita
Microglia are the resident immune cells of the central nervous system and are important for immune processes. Besides their classical roles in pathological conditions, these cells also dynamically interact with neurons and influence their s...
Lactobacillus rhamnosus GG soluble mediators ameliorate early life stress-induced visceral hypersensitivity and changes in spinal cord gene expression [0.03%]
鼠李糖乳杆菌GG胞壁成分可改善早期生活应激诱导的内脏高敏感及脊髓基因表达改变
Karen-Anne McVey Neufeld,Conall R Strain,Matteo M Pusceddu et al.
Karen-Anne McVey Neufeld et al.
Visceral hypersensitivity is a hallmark of many functional and stress-related gastrointestinal disorders, and there is growing evidence that the gut microbiota may play a role in its pathophysiology. It has previously been shown that early ...
Bibiana C Mota,Áine M Kelly
Bibiana C Mota
Experimental and epidemiological evidence suggest that modifiable lifestyle factors, including physical exercise, can build structural and cognitive reserve in the brain, increasing resilience to injury and insult. Accordingly, exercise can...
Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats [0.03%]
听觉恐惧条件反射会改变耳蜗核的神经增益：自由行为大鼠的无线神经记录研究
Antonio G Paolini,Simeon J Morgan,Jee Hyun Kim
Antonio G Paolini
Anxiety disorders involve distorted perception of the world including increased saliency of stress-associated cues. However, plasticity in the initial sensory regions of the brain following a fearful experience has never been examined. The ...
New developments in Huntington's disease and other triplet repeat diseases: DNA repair turns to the dark side [0.03%]
亨廷顿病和其他三核苷酸重复疾病的新进展：DNA修复的“黑化”作用
Robert S Lahue
Robert S Lahue
Huntington's disease (HD) is a fatal, inherited neurodegenerative disease that causes neuronal death, particularly in medium spiny neurons. HD leads to serious and progressive motor, cognitive and psychiatric symptoms. Its genetic basis is ...