3D hydrogel models of the neurovascular unit to investigate blood-brain barrier dysfunction [0.03%]
用于研究血脑屏障功能障碍的神经血管单元三维水凝胶模型
Geoffrey Potjewyd,Katherine A B Kellett,Nigel M Hooper
Geoffrey Potjewyd
The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding extracellular matrix (ECM), is an important interface bet...
Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment? [0.03%]
大脑中的传统蛋白激酶C：将抗癌药物改作神经退行性治疗？
Gema Lordén,Alexandra C Newton
Gema Lordén
Protein Kinase C (PKC) isozymes are tightly regulated kinases that transduce a myriad of signals from receptor-mediated hydrolysis of membrane phospholipids. They play an important role in brain physiology, and dysregulation of PKC activity...
Super-resolution imaging to reveal the nanostructure of tripartite synapses [0.03%]
超高分辨率显微镜揭示三元突触的纳米结构
Natalija Aleksejenko,Janosch P Heller
Natalija Aleksejenko
Even though neurons are the main drivers of information processing in the brain and spinal cord, other cell types are important to mediate adequate flow of information. These include electrically passive glial cells such as microglia and as...
A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment [0.03%]
棘手的情况：蛋白质棕榈酰化的调节与功能以及对轴突和轴突初始段的特别关注
Andrey A Petropavlovskiy,Jordan A Kogut,Arshia Leekha et al.
Andrey A Petropavlovskiy et al.
In neurons, the axon and axon initial segment (AIS) are critical structures for action potential initiation and propagation. Their formation and function rely on tight compartmentalisation, a process where specific proteins are trafficked t...
The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease [0.03%]
中脑多巴胺神经元的免疫原性及其对帕金森病神经移植物试验的影响
Shamma Qarin,Sarah K Howlett,Joanne L Jones et al.
Shamma Qarin et al.
Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson's disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the most successful...
Anti-inflammatory cytokine-eluting collagen hydrogel reduces the host immune response to dopaminergic cell transplants in a rat model of Parkinson's disease [0.03%]
载有抗炎细胞因子的胶原蛋白水凝胶降低帕金森病大鼠模型多巴胺能细胞移植后的宿主免疫反应
Sílvia Cabré,Verónica Alamilla,Niamh Moriarty et al.
Sílvia Cabré et al.
In cell replacement approaches for Parkinson's disease, the intracerebral implantation of dopamine neuron-rich grafts generates a neuroinflammatory response to the grafted cells that contributes to its varied outcome. Thus, the aim of the p...
Sónia R Pereira,Becky Hackett,David N O&#x;Driscoll et al.
Sónia R Pereira et al.
Cannabidiol (CBD), one of the primary non-euphoric components in the Cannabis sativa L. plant, has undergone clinical development over the last number of years as a therapeutic for patients with Lennox-Gastaut syndrome and Dravet syndromes....
Eleanor Catherine Sams
Eleanor Catherine Sams
More than half of the human brain volume is made up of white matter: regions where axons are coated in myelin, which primarily functions to increase the conduction speed of axon potentials. White matter volume significantly decreases with a...
Jara M Baena-Montes,Sahar Avazzadeh,Leo R Quinlan
Jara M Baena-Montes
α-synuclein is an increasingly prominent player in the pathology of a variety of neurodegenerative conditions. Parkinson's disease (PD) is a neurodegenerative disorder that affects mainly the dopaminergic (DA) neurons in the substantia nig...
Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction [0.03%]
利用α-klono的神经保护作用对抗衰老和神经退行性认知功能障碍
Kelsey Hanson,Kate Fisher,Nigel M Hooper
Kelsey Hanson
Cognitive dysfunction is a key symptom of ageing and neurodegenerative disorders, such as Alzheimer's disease (AD). Strategies to enhance cognition would impact the quality of life for a significant proportion of the ageing population. The ...