David Coupe,Torsten Bossing
David Coupe
Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs throug...
Yixing Wu,Nicole R West,Anita Bhattacharyya et al.
Yixing Wu et al.
Down syndrome (DS) is the most common chromosomal abnormality and leads to intellectual disability, increased risk of cardiac defects, and an altered immune response. Individuals with DS have an extra full or partial copy of chromosome 21 (...
Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes [0.03%]
利用哺乳动物眼睛内的内源性大麻素信号系统保护视网膜神经节细胞
Greg Maguire,Christy Eubanks,George Ayoub
Greg Maguire
Cannabinoid and glutamatergic signaling systems in the human retina coexist and greatly influence one another. Under glaucomatous conditions, excess levels of glutamate accrete in the retinal ganglion cell (RGC) layer. The present study tes...
Cholinergic blockade of neuroinflammation: from tissue to RNA regulators [0.03%]
胆碱能抗炎作用：从组织到RNA调控因子
Tamara Zorbaz,Nimrod Madrer,Hermona Soreq
Tamara Zorbaz
Inflammatory stimuli and consequent pro-inflammatory immune responses may facilitate neurodegeneration and threaten survival following pathogen infection or trauma, but potential controllers preventing these risks are incompletely understoo...
Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice [0.03%]
慢性运动对老龄小鼠认知灵活性的性别依赖性影响但不是海马bdnf的影响
Annabel K Short,Viet Bui,Isabel C Zbukvic et al.
Annabel K Short et al.
Cognitive impairments associated with advanced age involve alterations in the hippocampus that changes with experience throughout life. The hippocampus is critical for cognitive flexibility involved with extinction and reinstatement of cond...
Animal models of Parkinson's disease: a guide to selecting the optimal model for your research [0.03%]
帕金森病的动物模型：选择最佳研究模型的指南
Joana Lama,Yazead Buhidma,Edward J R Fletcher et al.
Joana Lama et al.
Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein (SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial pathogenetic mechanisms and expression of a plethora of motor and...
Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model [0.03%]
人多能干细胞模型中TGFβ信号调控中间神经元神经发生的作用机制研究
Maria Santos Cruz,Meng Li
Maria Santos Cruz
Cortical interneurons are GABAergic inhibitory cells that connect locally in the neocortex and play a pivotal role in shaping cortical network activities. Dysfunction of these cells is believed to lead to runaway excitation underlying seizu...
Do foetal transplant studies continue to be justified in Huntington's disease? [0.03%]
胎儿移植研究是否仍可用于亨廷顿病的治疗？
Oliver J M Bartley,Mariah J Lelos,William P Gray et al.
Oliver J M Bartley et al.
Early CNS transplantation studies used foetal derived cell products to provide a foundation of evidence for functional recovery in preclinical studies and early clinical trials. However, it was soon recognised that the practical limitations...
Mutations in DISC1 alter IP3R and voltage-gated Ca2+ channel functioning, implications for major mental illness [0.03%]
DISC1突变改变IP3R和电压门控钙通道的功能及其对精神疾病的影响
Ann R Rittenhouse,Sonia Ortiz-Miranda,Agata Jurczyk
Ann R Rittenhouse
Disrupted in Schizophrenia 1 (DISC1) participates in a wide variety of developmental processes of central neurons. It also serves critical roles that underlie cognitive functioning in adult central neurons. Here we summarize DISC1's general...
Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine [0.03%]
作用于多巴胺高亲和力转运蛋白的刺激性新型精神活性物质的作用分子机制
Michelle A Sahai,Jolanta Opacka-Juffry
Michelle A Sahai
Drug misuse is a significant social and public health problem worldwide. Misused substances exert their neurobehavioural effects through changing neural signalling within the brain, many of them leading to substance dependence and addiction...