In vivo imaging of axonal transport in peripheral nerves of rodent forelimbs [0.03%]
体内四肢外周神经轴突运输的成像研究
Qiuhan Lang,Giampietro Schiavo,James N Sleigh
Qiuhan Lang
Axonal transport is the essential process by which neurons actively traffic a variety of cargoes between the cell soma and axon terminals. Accordingly, dysfunctional axonal transport is linked to many nervous system conditions. Therefore, b...
Caroline Weglinski,Alexander Jeans
Caroline Weglinski
The amyloid hypothesis, which proposes that accumulation of the peptide amyloid-β at synapses is the key driver of Alzheimer's disease (AD) pathogenesis, has been the dominant idea in the field of Alzheimer's research for nearly 30 years. ...
S Clare Stanford
S Clare Stanford
This themed collection celebrates 125 years of the synapse through a series of reviews written by a team of international experts in the field. The first in the series explains Sherrington's contribution to the debate about the term 'synaps...
Caroline S Copeland,Thomas E Salt
Caroline S Copeland
The thalamus plays a pivotal role in the integration and processing of sensory, motor, and cognitive information. It is therefore important to understand how the thalamus operates in states of both health and disease. In the present review,...
Introducing a new themed collection on emerging technologies for research models of human neuronal disorders in vivo and in vitro [0.03%]
特刊介绍：新兴技术在人神经元疾病体内外研究模型中的应用
Thomas J Cunningham,Clare Stanford
Thomas J Cunningham
This themed collection of articles was prompted by a collaboration between Neuronal Signaling and the British Neuroscience Association. The Biochemical Society and Portland Press organised a symposium at the BNA Festival of Neuroscience in ...
Anna Sanchez Avila,Christopher M Henstridge
Anna Sanchez Avila
Synapses are minuscule, intricate structures crucial for the correct communication between neurons. In the 125 years since the term synapse was first coined, we have advanced a long way when it comes to our understanding of how they work an...
E M Tansey
E M Tansey
This paper provides a review of some of the major historical developments in synaptic research and neurotransmission since the first appearance of the word 'synapsis' in 1895. The key contributions and inter-relationships of several signifi...
Keeping synapses in shape: degradation pathways in the healthy and aging brain [0.03%]
维持突触健康：正常和老化大脑中的降解途径
Marijn Kuijpers
Marijn Kuijpers
Synapses maintain their molecular composition, plasticity and function through the concerted action of protein synthesis and removal. The complex and polarized neuronal architecture poses specific challenges to the logistics of protein and ...
Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior [0.03%]
神经发育障碍中的神经突触蛋白：新的突变小鼠模型如何帮助我们链接突触功能与社会行为？
Tobias T Pohl,Hanna Hörnberg
Tobias T Pohl
Neurodevelopmental conditions (or neurodevelopmental disorders, NDDs) are highly heterogeneous with overlapping characteristics and shared genetic etiology. The large symptom variability and etiological heterogeneity have made it challengin...
Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease [0.03%]
靶向M1胆碱能受体在阿尔茨海默病中的作用
Louis Dwomoh,Gonzalo S Tejeda,Andrew B Tobin
Louis Dwomoh
Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and despite extensive research, only a few drugs are available for management of the disease. One strategy has been to up-regulate cholinergic neurotransmi...