c-Myc transactivates CFL1 to induce senescence-like phenotype and potentiate the bystander effects for the migration and proliferation in lung cancer cells [0.03%]
c-Myc通过活化CFL1诱导细胞衰老并增强旁观者效应从而抑制肺癌细胞迁移和增殖
Yen-Ting Chou,Jyh-Der Leu,Wan-Yu Yang et al.
Yen-Ting Chou et al.
Oncogene-induced senescence (OIS) is regarded a tumor suppressive mechanism in normal cells. Accumulated evidences, however, demonstrate that OIS would play a role in cancer promotion through the secretion of senescence associated secretory...
RRx-001 inhibits G6PD to deplete NADPH and trigger disulfidptosis coupled with DAMP-mediated immunogenic cell death in hepatocellular carcinoma [0.03%]
RRx-001通过抑制G6PD耗竭NAPDH并触发肝癌细胞中的二硫键介导的免疫原性细胞死亡耦合的disulfidptosis作用
Hailian Huang,Yongfei He,Jingxuan Chen et al.
Hailian Huang et al.
Disulfidptosis is a recently identified form of programmed cell death driven by NADPH metabolic imbalance and disulfide stress, but its therapeutic relevance in hepatocellular carcinoma (HCC) remains poorly understood. RRx-001, a clinical-s...
Polystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism [0.03%]
聚苯乙烯纳米颗粒通过ACSS2介导的花生四烯酸代谢重编程促进子宫内膜癌发展
Xiangchun Huang,Li Xu,Jielin Wang et al.
Xiangchun Huang et al.
Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, placenta...
Tumor-associated epilepsy and high expression of xCT shape the proteome of IDH-wildtype glioblastoma [0.03%]
肿瘤相关性癫痫和xCT高表达改变IDH野生型胶质母细胞瘤蛋白组学特征
Iris Divé,Jasmin A Schäfer,Katharina J Weber et al.
Iris Divé et al.
Given the role of glutamate signaling in glioma-associated epilepsy (GAE) and glioma cell growth, amino acid transporters have gained attention as therapeutic targets. Here, we conducted a comparative analysis of four key transporters-xCT, ...
Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis [0.03%]
转录组分析前额叶皮质鉴定出炎症基因与多发性硬化模型中认知障碍相关的研究
Luca Zupo,Annalisa Adinolfi,Marco Pieraccioli et al.
Luca Zupo et al.
Cognitive impairment (CI) is a hallmark of multiple sclerosis (MS). Despite its relevance, however, knowledge of the key steps involved in its pathogenesis remains incomplete. Consequently, predictive biomarkers and actionable therapeutic o...
RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment [0.03%]
RUNX1通过限制STAT1-GITRL信号通路来塑造免疫抑制性结直肠癌微环境
Wenting He,Lisheng Zheng,Weiye Huang et al.
Wenting He et al.
The oncogenic role of RUNX1 in epithelial tumors is increasingly recognized, however, its function and mechanism within the tumor immune microenvironment (TME) of colorectal cancer (CRC) remain unclear. This study investigates the contribut...
A novel PAAoptosis-inducing ERRα-targeting compound for combating hematopoietic and solid cancers [0.03%]
一种新型靶向ERRα诱导白血病和实体瘤细胞凋亡的PAA衍生物抗肿瘤化合物
Wonhyoung Seo,Yerim Heo,Khang Vuong Tran et al.
Wonhyoung Seo et al.
Estrogen-related receptor-α (ERRα; NR3B1) is an orphan nuclear receptor that drives the progression of several cancers. To develop novel ERRα-targeting therapeutics, we designed and evaluated the function of a new compound, PAMT-001, whi...
NFATC2-mediated CST1 upregulation drives cholangiocarcinoma growth and metastasis [0.03%]
NFATC2介导的CST1上调驱动肝内胆管癌生长和转移
Wei Zhao,Jing Zhao,Kun Li et al.
Wei Zhao et al.
Intrahepatic cholangiocarcinoma (CCA) is a highly aggressive malignancy arising from the intrahepatic biliary epithelium with insidious onset and dismal clinical outcomes. The lack of reliable early diagnostic markers and effective therapeu...
SMARCA4 promotes lineage plasticity and enzalutamide resistance in prostate cancer by regulating PROX1 via H3K27 acetylation [0.03%]
SMARCA4通过H3K27乙酰化调控PROX1促进前列腺癌的谱系可塑性及恩杂鲁胺耐药性
Chenwei Wu,Mayao Luo,Chaojian Wu et al.
Chenwei Wu et al.
Enzalutamide resistance is a dynamic process often culminating in the aggressive progression to neuroendocrine prostate cancer (NEPC). This lineage plasticity is hypothesized to be driven by underlying epigenetic alterations, yet the core m...
Glycolytic reprogramming mediated by the ADAM12/IGF1 axis promotes ossification of the posterior longitudinal ligament [0.03%]
ADAM12/IGF1轴介导的糖酵解重构促进黄韧带骨化
Qi Zhao,Hao Wu,Dong Xie et al.
Qi Zhao et al.
Ossification of the posterior longitudinal ligament (OPLL) is a debilitating spinal disorder characterized by heterotopic bone formation and severe neurological deficits, yet its underlying pathogenic mechanisms remain poorly understood. He...