Therapeutic potential of cAMP-mediated lysosomal pH modulation in ATP6V1B2-related neuropathology [0.03%]
cAMP介导的溶酶体pH调节在ATP6V1B2相关神经病理中的治疗潜力
Lu Zheng,Weihao Zhao,Guang Yang et al.
Lu Zheng et al.
Pathogenic variants in ATP6V1B2, which encodes a critical subunit of vacuolar-type H+-ATPases (V-ATPases), disrupt lysosomal acidification via haploinsufficiency and clinically manifest as intellectual disability and seizure disorders. Desp...
Targeting glioblastoma mitochondrial metabolism with S-Gboxin induces cytotoxicity under conditions of the tumor microenvironment [0.03%]
靶向胶质母细胞瘤线粒体代谢的S-Gboxin在肿瘤微环境条件下诱导细胞毒性
Jan-Béla Weinem,Hans Urban,Benedikt Sauer et al.
Jan-Béla Weinem et al.
Glioblastoma (GB) is the most common primary malignant brain tumor in adults. Gboxin, a novel compound that targets oxidative phosphorylation via complex V inhibition, has shown promise in preclinical models of GB. We examined the efficacy ...
Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury [0.03%]
大麻素受体2通过调节损伤后NLRP3-GSDMD介导的巨噬细胞焦亡促进骨骼肌再生
Xinjie Li,Haomiao Yuan,Shuyang Mu et al.
Xinjie Li et al.
Skeletal muscle repair after injury requires coordinated immune responses. The cannabinoid type 2 receptor (CB2R) has been implicated in this process; however, its molecular mechanism in regulating inflammation and muscle regeneration, part...
IOA-244, a novel p110δ PI3K inhibitor, blocks breast tumour progression on either mono- or combined-therapy [0.03%]
一种新型的p110δPI3K抑制剂IOA-244通过单独或联合用药阻断乳腺肿瘤的发展
Evangelia Goulielmaki,Anna Tsapara,Lydia Xenou et al.
Evangelia Goulielmaki et al.
The clinical approval of p110δ PI3K inhibitors raised hopes in treating aggressive tumours expressing high levels of non-mutated p110δ, however, the severe adverse effects that those inhibitors caused became a barrier to their clinical ap...
Variant-divergent death: Omicron intensifies bystander T-cell apoptosis via GDF15-BCL2L13 [0.03%]
变异分歧的死亡：Omnicron亚系通过GDF15-BCL2L13加剧旁观者T细胞凋亡
Chao Gao,Hanbing Chen,Ying Chi et al.
Chao Gao et al.
Background: Severe Omicron cases present profound lymphocytopenia, suggesting variant-specific immune injury. Results: We identify CD63...
NRIP1 co-activates nuclear translocated FOXO3 to upregulate TFAM expression and promote radioresistance in non-small cell lung cancer [0.03%]
NRIP1通过共激活转位至细胞核中的FOXO3上调TFAM表达并促进非小细胞肺癌放射耐受性增强
Ying Zha,Hui Huang,Yulian Liu et al.
Ying Zha et al.
Radioresistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). This study investigated the coordinated regulation of TFAM, FOXO3, and NRIP1 in NSCLC radioresistance. Radioresistant cell lines (A549-RR and H...
Simona Romano,Laura Marrone,Gennaro Acanfora et al.
Simona Romano et al.
FKBP51 is a multifunctional immunophilin that regulates key cellular pathways, including NF-κB signaling, AKT activation, and steroid receptor trafficking. Alternative splicing of the FKBP5 gene generates a shorter isoform, FKBP51s, lackin...
Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition [0.03%]
炎症性巨噬细胞衍生的纤溶酶原激活物抑制剂-1通过抑制效应吞噬作用加剧炎症反应
Abd Aziz Ibrahim,Hiromi Miura,Tomoya Terada et al.
Abd Aziz Ibrahim et al.
Plasminogen activator inhibitor-1 (PAI-1) is significantly upregulated during inflammatory responses, and elevated PAI-1 levels are associated with poor prognosis in various diseases. However, the precise mechanism through which PAI-1 exace...
Shijun Bao,Fengxu Chen,Ziyi Guo et al.
Shijun Bao et al.
Nerve injury-induced protein 1 (NINJ1) is a multifunctional membrane protein historically studied for its roles in nerve regeneration and cell adhesion. A groundbreaking study fundamentally revised our understanding by demonstrating that NI...
Mitochondrial IκBα fuels cancer progression through metabolic rewiring, endothelial activation, and thrombotic spread [0.03%]
线粒体IκBα通过代谢重组、内皮激活和血栓扩散促进癌症进展
Menga Alessio,Jessica Petiti,Roberta Basile et al.
Menga Alessio et al.
Mitochondria play a central role in metastatic spread and cancer progression, with the IκBα/NF-κB signaling axis acting as a key regulator of both processes. We suggest that a stable fraction of IκBα localizes to mitochondria, where it...