Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A [0.03%]
多柔比星通过激活乳酸脱氢酶A促进肿瘤相关巨噬细胞产生炎症性细胞因子
Bin Liu,Wei Yang,Shuo Feng et al.
Bin Liu et al.
Glioblastoma (GBM) presents a significant challenge because of its immunosuppressive microenvironment. The standard treatment protocol, including surgery, radiotherapy, and temozolomide, has been unable to alleviate immunosuppression. Doxor...
Paola Bianca,Chiara Modica,Mariavittoria Verrillo et al.
Paola Bianca et al.
The green oncology paradigm emphasizes the use of natural products in cancer treatment to protect the environment while reducing the adverse effects associated with conventional therapies. In this context, humic substances (HSs), derived fr...
Correction: Periplogenin attenuates LPS-mediated inflammatory osteolysis through the suppression of osteoclastogenesis via reducing the NF-κB and MAPK signaling pathways [0.03%]
校正：Periplogenin通过减少NF-κB和MAPK信号通路来抑制破骨细胞生成，从而缓解LPS介导的炎性骨溶解作用
Kai Gan,Haoyu Lian,Tao Yang et al.
Kai Gan et al.
Published Erratum
Cell death discovery. 2026 Mar 30;12(1):126. DOI:10.1038/s41420-026-03007-z 2026
A20 enhances the migration and metastasis of gastric cancer cells by promoting occludin degradation [0.03%]
A20通过促进闭合蛋白降解增强胃癌细胞迁移和转移
Yu-Ting Kuo,Hao-Chen Wang,Yan-Shen Shan
Yu-Ting Kuo
Chronic inflammation is a well-established risk factor in the development of gastric cancer (GC). Tumor necrosis factor α-induced protein 3 (TNFAIP3, also known as A20) is an inflammation-associated protein that functions as an oncogene in...
Lithium ameliorates neural differentiation restoring cell death balance in Cornelia de Lange syndrome 2D and 3D models [0.03%]
锂改善科内在利亚综合征的神经分化并恢复细胞死亡平衡（二维和三维模型）
Chiara Parodi,Antonella Lettieri,Paolo Grazioli et al.
Chiara Parodi et al.
Cornelia de Lange syndrome (CdLS) is a rare genetic disorder that affects almost any organ, including the central nervous system. It leads to a wide range of neurodevelopmental delays, and there are currently no available clinical treatment...
TUFM: a central regulator in mitochondrial quality control and beyond [0.03%]
TUFM：调控线粒体质量控制等过程的核心调节因子
Xuanyi Li,Liangjie Dong,Tian Xiao et al.
Xuanyi Li et al.
Tu translation elongation factor, mitochondrial (TUFM) is a highly conserved, nuclear-encoded GTPase that is indispensable for mitochondrial protein synthesis. Beyond this canonical function, TUFM has emerged as a central regulator of mitoc...
AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes [0.03%]
腺苷酸活化蛋白激酶在生理状态下不参与肾小球系膜细胞和足细胞功能但在糖尿病实验模型中可防止肾小球纤维化
Swayam Prakash Srivastava,Olivia Kopasz-Gemmen,Abhiram Kunamneni et al.
Swayam Prakash Srivastava et al.
AMP-activated protein kinase (AMPK) has been postulated to be crucial in regulating various renal physiology and pathophysiology processes, including energy metabolism, ion and water transport, inflammation, and hypertrophy. However, the sp...
Lactate-mediated NK cell dysfunction as a prognostic marker and therapeutic target in breast cancer [0.03%]
乳酸介导的NK细胞功能障碍作为乳腺癌的预后标志和治疗靶点
Simone Ielpo,Francesca Barberini,Alice Gaiba et al.
Simone Ielpo et al.
Lactate is recognized as a crucial signalling molecule within the tumor microenvironment, where it shapes immune responses by modulating various cell populations, including T cells and macrophages. However, its effect on natural killer (NK)...
CXCR4, CXCR7 and PBRM1 are responsible for everolimus and cabozantinib resistance in human renal cancer cells [0.03%]
人肾癌细胞中导致艾日布林和卡博扎尼布耐药的基因CXCR4、CXCR7和PBRM1
Federica Auletta,Caterina Ieranò,Dario Guido Di Febbraro et al.
Federica Auletta et al.
The mTOR inhibitor everolimus (RAD001), previously used in first-line treatment of metastatic renal cancer (mRCC), is currently reserved for the following lines of therapy. However, many patients eventually develop resistance to RAD001. To ...
MEKK3 bridges gut-brain communication and cerebral cavernous malformation pathogenesis [0.03%]
MEKK3连接肠道-大脑通讯和脑海绵状血管瘤的发生发展过程
Peng Cheng,Hongkuan Han,Ying Huang et al.
Peng Cheng et al.
Cerebral cavernous malformation (CCM) is a condition affecting the brain vasculature, characterized by endothelial dysfunction and abnormal vascular structure. In recent years, the gut-brain axis has emerged as a significant regulatory fact...