Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection [0.03%]
过度的焦亡介导低致死率流感病毒肺炎恶化及金黄色葡萄球菌继发感染加重病情
Zi-Chen Tian,Yang Liu,Yi-Jun Niu et al.
Zi-Chen Tian et al.
Co-infection with influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) often causes severe pneumonia clinically; however, the role of innate immunity in this setting remains poorly understood. In our study, we esta...
Caspase-3/Drice as a critical regulator of actin dynamics through its dual control of small RhoGTPase family and Gelsolin in the Malpighian tubules of Drosophila [0.03%]
Caspase-3/Drice通过其对小RhoGTP酶家族和Gelsolin的双重控制作为果蝇Malpighian管中肌动蛋白动力学的关键调节因子
Saurabh Chand Sagar,Madhu G Tapadia
Saurabh Chand Sagar
Caspases are well-known executioner enzymes that drive programmed cell death. However, growing evidence indicates their crucial non-apoptotic functions in regulating proliferation, differentiation, endocytic trafficking, cell polarity, morp...
A unified therapeutic theory for treating cancer via master regulators of the universal apoptosis network [0.03%]
抗癌通用疗法理论——通过凋亡网络的总控调节因子进行治疗
Davis Joseph,Florian Kongoli,Fukka You et al.
Davis Joseph et al.
Three universal types of cancer are identified, based on the malfunction of a certain set of proteins and regulatory RNAs, irrespective of the organ in which they are located: Cancer Type 1, where cancer cells lack either a functional (a) P...
Non-enzymatic function of QSOX2 directly regulates the JUNB-ITGB4 axis and enhanced resistance to osimertinib in EGFR-mutation lung adenocarcinoma [0.03%]
醌红酶还原酶2非酶功能通过直接调节JUNB-ITGB4轴增强肺癌对奥希替尼的耐药性
Chaoxing Liu,Siya Wang,Rong Qi et al.
Chaoxing Liu et al.
Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) represent a significant advancement in the targeted therapy of lung adenocarcinoma (LUAD), markedly prolonging patient overall survival. However, resis...
Mechanistic insights into SOCS5-related DNA damage and cellular senescence in diabetic retinopathy [0.03%]
糖尿病性视网膜病变中SOCS5相关DNA损伤及细胞衰老的机制研究
Di Yang,Siduo Lu,Hongmei Liu et al.
Di Yang et al.
This study elucidated the mechanistic role of the Suppressor of Cytokine Signaling 5 (SOCS5) in diabetic retinopathy (DR), focusing on DNA damage and cellular senescence pathways. Utilizing both in vitro (high glucose (HG)-induced human ret...
Protein lactylation: a metabolic signal driving cancer therapy resistance [0.03%]
蛋白质乳酰化：一种驱动癌症治疗抗性的代谢信号
Silvia D&#x;amico,Sara Giovannini,Gerry Melino et al.
Silvia D&#x;amico et al.
Unlike normal cells, which primarily rely on oxidative phosphorylation, cancer cells reprogram their metabolism by preferentially utilizing glycolysis even in the presence of oxygen to generate ATP. As a result, cancer cells and the tumor m...
Store-operated calcium entry drives alcohol-exacerbated neuroinflammation in retinal degeneration [0.03%]
酒精加剧视网膜退行性变中 store 操作钙进入驱动的神经炎症
Théo Henrique de Lima-Vasconcellos,Bruna de Albuquerque Menezes,Marília Inês Móvio et al.
Théo Henrique de Lima-Vasconcellos et al.
Patients with neurodegenerative diseases such as retinitis pigmentosa (RP) may engage in maladaptive coping behaviors, including alcohol misuse, which can aggravate disease progression. Neuroinflammation, a hallmark of RP, is largely driven...
Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages [0.03%]
脑转移瘤表现出驻留和浸润巨噬细胞的空间模式差异
Avinoam Ratzabi,Itai M Caspit,Ira Telechi et al.
Avinoam Ratzabi et al.
Brain metastases (BrM) are a leading cause of morbidity and mortality, arising in multiple brain compartments. BrM colonization and progression are shaped by interactions with distinct tumor-associated macrophage (TAM) subsets, including mi...
SNHG10 promotes tumorigenesis through the EGFR/AKT/ERK/mTOR and miR-150-5p/VEGF-A axis, along with gemcitabine resistance in pancreatic ductal adenocarcinoma [0.03%]
SNHG10通过EGFR/AKT/ERK/mTOR和miR-150-5p/VEGF-A轴促进胰腺导管腺癌的肿瘤发生及吉西他滨耐药性
Gouri Pandya,Aishwarya Singh,Suman Saurav et al.
Gouri Pandya et al.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and often fatal cancer with limited treatment options. Small nucleolar RNA host gene 10 (SNHG10) has emerged as a key regulator in the progression and metastasis of human cancers. How...
O-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications [0.03%]
UDP-葡萄糖脱氢酶的O-GlcNAc酰化：免疫代谢调控的新见解及其治疗意义
Qiang Wu,Ting Lei,Shujing Wang
Qiang Wu