ARHGAP21 enhances metastasis in hepatocellular carcinoma by inhibiting ubiquitination of filamin A [0.03%]
ARHGAP21通过抑制Filamin A泛素化促进肝癌转移
Huijun Yao,Ziping Xie,Xingyu Tao et al.
Huijun Yao et al.
Rho GTPase-activating protein 21 (ARHGAP21) plays a role in the occurrence and development of certain cancers, but its function in hepatocellular carcinoma (HCC) remains unclear. In this study, elevated ARHGAP21 expression was observed in b...
Glycosylation-driven necroptosis in retinal degeneration: dual rescue by AAV8 gene therapy and RIPK1 inhibition [0.03%]
视网膜退行性变中糖基化驱动的坏死性凋亡及AAV8基因治疗和RIPK1抑制剂的双重修复作用
Jia-Ying Chien,Peng Yeong Woon,Hsien-Yang Tsai et al.
Jia-Ying Chien et al.
Glycosylation defects are increasingly implicated across neurodegenerative diseases, yet the mechanism by which perturbed O-mannosylation drives neuronal death-and how to reverse it-remains unclear. Here we show that a disease-associated PO...
Lipid droplets in neurodegenerative diseases: pathological drivers and therapeutic vulnerabilities [0.03%]
脂滴在神经退行性疾病中的作用：病理驱动因素和治疗脆弱性
Ourania Papapanagiotou,Kian Cotton,Christopher Edwards et al.
Ourania Papapanagiotou et al.
Lipid droplets (LDs) are dynamic intracellular organelles traditionally associated with energy storage, which have become increasingly recognised for their versatile roles in cellular metabolism and signalling. In the brain, LDs have emerge...
Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2-FASN axis [0.03%]
低剂量TNF-α通过TRAF2-FASN轴驱动胶质母细胞瘤恶性进展和脂质代谢
Maorong Cai,Yang Liu,Xinyu Mao et al.
Maorong Cai et al.
Lipid metabolism plays a critical role in the progression of cancers, including glioblastoma (GBM). Tumor necrosis factor-α (TNF-α) exhibits a dual role in the tumor microenvironment: at high concentrations, it induces cell death and exer...
NAT10 promotes cisplatin resistance and immune escape by increasing the expression of DUSP1 and PD-L1 in gastric cancer [0.03%]
NAT10通过增加DUSP1和PD-L1的表达促进胃癌顺铂耐药及免疫逃逸
Lilin Qian,Wenrong Gao,Xinyi Wang et al.
Lilin Qian et al.
Developing resistance to chemotherapy drugs and evading the killing effect of the immune system are the main obstacles in the clinical treatment of gastric cancer. However, the potential mechanism remains poorly understood. N-acetyltransfer...
Proteasome dysfunction underlies HERC2-linked neurodevelopmental disorder with Angelman-like clinical features [0.03%]
泛素蛋白酶体功能障碍与HERC2相关的具有天使人综合症临床特征的神经发育性疾病
Joan Sala-Gaston,Laura Costa-Sastre,Manel Garcia-Diez et al.
Joan Sala-Gaston et al.
Biallelic hypomorphic variants in the E3 ubiquitin ligase HERC2 cause a neurodevelopmental disorder clinically resembling Angelman syndrome, characterized by global developmental delay, intellectual disability, autism spectrum features, and...
Leveraging drug-specific genes to identify sensitizers for resistant cancer cell lines [0.03%]
利用药物特异性基因鉴定耐药癌细胞系的敏感因子
G Pepe,E Valentini,R Appierdo et al.
G Pepe et al.
Therapeutic resistance remains a major obstacle in oncology, often arising from transcriptional reprogramming that enables cancer cells to escape drug-induced cytotoxicity. We aimed to develop a computational-experimental strategy to identi...
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactylation and metabolic reprogramming [0.03%]
FGFR1通过调节SIRT3依赖性的乳酰化和代谢重构来抑制卵巢癌进展
Fan Jiang,Huaju Huang,Zhe Dong et al.
Fan Jiang et al.
Ovarian cancer (OC) is an aggressive gynecological malignancy with poor prognosis, largely due to late-stage diagnosis and high metastatic potential. However, the functional role and regulatory mechanisms of fibroblast growth factor recepto...
Programmed cell death in cancer: targeting necroptosis to kill tumor cell [0.03%]
癌症中细胞凋亡的发生：靶向坏死程序以杀死肿瘤细胞
Jiahao Liang,Chenchen Tan,Xia Li et al.
Jiahao Liang et al.
Necroptosis is a precisely regulated form of programmed cell death (PCD) that exhibits necrotic morphology while being orchestrated receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and mixed line...
Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions [0.03%]
更正：戈梅辛肽的细胞毒性是由糖脂代谢途径和脂质胆固醇相互作用介导的
Isabel Fernandez-Carrasco,Javier Moral-Sanz,Sergey Kurdyukov et al.
Isabel Fernandez-Carrasco et al.
Published Erratum
Cell death discovery. 2026 Apr 2;12(1):179. DOI:10.1038/s41420-026-03009-x 2026