Dual control of liver regeneration by Nr1d1 homeostasis and Klf2 checkpoint [0.03%]
Nr1d1稳态与Klf2节点共同调控肝再生
Bingyu Ye,Dejian Xie,Wenlong Shen et al.
Bingyu Ye et al.
Following extensive liver resections, diminished liver regeneration impairs the maintenance or restoration of sufficient functional liver mass. Currently, effective therapies to restore liver regeneration are lacking, rendering liver transp...
Enhanced precision in cell culture analytics: leveraging artificial intelligence for unbiased and non-destructive assessment of cell growth and viability [0.03%]
改进的细胞培养分析精度：利用人工智能进行无偏见和非破坏性的细胞生长和存活评估
Cheung Pang Wong,Nasrin Khazamipour,Soroush Aalibagi et al.
Cheung Pang Wong et al.
Precise assessment of cell growth, count, and viability is a prerequisite for biological and medical research. Traditional cell analytics involve manual processes, such as cell counting or reagent-based approaches that are user-dependent an...
A comparative analysis of serum and tissue proteomic profiles in non-small cell lung cancer patients with or without brain metastasis [0.03%]
伴有和不伴脑转移的非小细胞肺癌患者血清及组织蛋白质组特征比较分析
Yongtao Zheng,Yueting Xiong,Yuxiao Ma et al.
Yongtao Zheng et al.
To identify specific, sensitive, and non-invasive circulating protein biomarkers that could facilitate the diagnosis of brain metastasis (BrM) and improve risk prediction for BrM among patients with non-small cell lung cancer (NSCLC). We pe...
Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD) [0.03%]
过氧化物酶体增殖激活受体（PPAR）在糖尿病肾脏疾病发病机制中的作用
Zhi Zheng,Yunkuo Li,Yujie Pan
Zhi Zheng
Diabetic kidney disease (DKD), a prevalent microvascular complication of diabetes, is a leading cause of chronic kidney disease and end-stage renal disease. Moreover, it plays a crucial role in the morbidity and mortality of diabetic patien...
High-throughput strategy for targeting MDM2 in uveal melanoma to reverse radiation therapy resistance [0.03%]
针对视网膜色素上皮细胞黑色素瘤的高通量靶向MDM2策略以逆转放疗抗性
Qi Zhu,Xi Gong,Sirong Zhang et al.
Qi Zhu et al.
Uveal melanoma (UM) presents a formidable clinical challenge due to its marked resistance to radiotherapy. In this study, an integrative strategy combining machine learning models with high-throughput screening platforms was employed to ide...
Bacterial protein-oleate complexes induce ferroptosis-like cell death in colorectal cancer cells by disrupting cell membranes and inhibiting the β-catenin-GPX4 axis [0.03%]
细菌蛋白-油酸复合物通过破坏细胞膜并抑制β-连环素-GPX4轴诱导结直肠癌细胞发生铁死亡
Naeem Ullah,Abdelbasset Yabrag,Amjad Ali et al.
Naeem Ullah et al.
The tumoricidal activity of human α-lactalbumin complexes, such as HAMLET and its α-helical domain with sodium oleate, is well-documented. However, the potential of bacterial α-helical proteins to form analogous anticancer complexes rema...
CX3CR1-mediated immune networks in sepsis: implications for precision therapy [0.03%]
脓毒症中CX3CR1介导的免疫网络：精确治疗的意义
Ying Tang,Lu Jia,Yigao Liu et al.
Ying Tang et al.
Sepsis is a life-threatening syndrome characterized by profound immune dysregulation in response to infection, and it remains a major cause of mortality worldwide. The CX3C chemokine receptor 1 (CX3CR1) has emerged as a pivotal regulator of...
TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to prolonged FS-induced epileptogenesis [0.03%]
由TREM2介导的小胶质细胞对抑制性突触的吞噬作用有助于FS诱导的癫痫发作持续存在的发生发展
Xiaoqian Wang,Hua Zhou,Yujie Zhai et al.
Xiaoqian Wang et al.
Febrile seizures (FS) are common convulsive episodes in childhood and an important etiological component in epilepsy. However, most currently available antiepileptic drugs cannot prevent epileptogenesis and may even exacerbate it. Triggerin...
Berry-derived gold nanoparticles induce integrated ROS-mediated apoptosis, immune modulation, and transcriptomic remodeling in 4T1 triple-negative cancer cells [0.03%]
由浆果衍生的金纳米粒子诱导4T1三阴性癌细胞内的ROS介导的凋亡，免疫调节和转录组重塑
Oladapo F Fagbohun,Adewale O Oladipo,Chengyu Gao et al.
Oladapo F Fagbohun et al.
Comprehensive molecular and phenotypic characterization of tumor models is still needed for a robust understanding of breast cancer mechanisms and therapies. Here, we explore the genome, transcriptome, and proteome of treated and untreated ...
Necrosis by sodium overload: a potential mechanism for renal diseases associated with mitochondrial dysfunction [0.03%]
钠超负荷引起的坏死：与线粒体功能障碍相关肾病的一种潜在发病机制
Quanhai Liu,Jiawei Lai,Jiancang Ma et al.
Quanhai Liu et al.