Uncovering MYOF as a novel therapeutic target in glioblastoma: mechanistic insights and drug discovery [0.03%]
揭示MYOF作为胶质母细胞瘤新治疗靶点的意义：机制见解和药物发现
Peiqi Zhao,Zhen Chen,Jiajie Zhu et al.
Peiqi Zhao et al.
Glioblastoma (GBM) is the most common type of primary malignant brain tumor, characterized by a poor prognosis, high recurrence rate, and elevated mortality. In recent years, gene-targeted therapies leveraging small molecule compounds have ...
Placenta models for HIV-1-ART-nicotine comorbidity research: advances and remaining challenges [0.03%]
用于HIV-1-ART-尼古丁合并症研究的胎盘模型：进展与面临的挑战
Sandip Godse,Aditya N Bade
Sandip Godse
Worldwide implementation of antiretroviral therapy (ART) for pregnant women living with human immunodeficiency virus type-1 (HIV-1) has markedly reduced mother-to-child HIV-1 transmission rate to less than one percent. Despite this benefit,...
PRMT6 acts as a pro-angiogenic factor in colorectal cancer [0.03%]
脯氨酰-tRNA合成酶相互作用蛋白1通过内质网应激促进结直肠癌血管生成和肿瘤生长
Haifeng Han,Xin Zhang,Mingxin Jin et al.
Haifeng Han et al.
The progression of colorectal cancer (CRC) is highly dependent on tumor angiogenesis, a process primarily regulated by hypoxia-inducible factor HIF-1α. This study focuses on the mechanistic role of protein arginine methyltransferase 6 (PRM...
Calcineurin/NFAT signaling in the temporal integration of Ca²⁺ stress in neurodegeneration [0.03%]
钙离子应激在神经退行性疾病中时间整合的钙/calmodulin依赖性蛋白磷酸酶信号通路
Bruna Da Silva Oliveira,Metello Innocenti,Francesca Granucci
Bruna Da Silva Oliveira
The calcineurin (CaN)/nuclear factor of activated T cells (NFAT) signalling axis is a Ca²⁺-responsive pathway that translates intracellular Ca²⁺ signals into long-term transcriptional programmes. Chronic disruption of intracellular Ca²...
Single-cell multi-omics deciphers the myofibro-inflammatory program of cancer-associated fibroblasts in triple-negative breast cancer [0.03%]
单细胞多组学解析三阴性乳腺癌相关成纤维细胞的肌成纤维炎症程序
Min Li,Jun Lin,Changwei Yang et al.
Min Li et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype associated with poor prognosis and limited therapeutic options, largely due to its unique tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) critically influence ...
SPINK2 in hematopoiesis and cancer: Biology and clinical implications [0.03%]
SPINK2在血液学和癌症中的作用：生物学及临床意义
L Deligio,T Loconte,A B Ventura et al.
L Deligio et al.
Serine protease inhibitors are essential regulators of tissue homeostasis, immunity, and cell survival, where they modulate tightly controlled proteolytic signaling networks that influence cell fate and microenvironmental interactions in di...
HMGA proteins in the nervous system: role in brain tumorigenesis and neurodegeneration [0.03%]
HMGA蛋白与神经系统肿瘤和神经退行性疾病的关系研究进展
Carolina Canè,Simona Paladino,Andrea Conte et al.
Carolina Canè et al.
High Mobility Group A (HMGA) proteins function as non-histone chromatin-associated architectural regulators that modulate gene transcription by modifying chromatin structure rather than binding DNA in a sequence-specific manner. By altering...
Intrinsic polyunsaturated fatty acid synthesis capacity dictates ferroptosis sensitivity under restricted arachidonic acid availability [0.03%]
固醇缺限时内源多不饱和脂肪酸合成能力决定细胞铁死亡敏感性
Min Wook Kim,Seo Young Jang,Ji-Yoon Lee et al.
Min Wook Kim et al.
Ferroptosis is an iron-dependent type of regulated cell death driven by lipid peroxidation, in which polyunsaturated fatty acids (PUFAs) in membrane phospholipids serve as key substrates. Here, we identify PUFA biosynthetic capacity as a ke...
Eosinophil diversity and function: emerging insights into subtypes and therapeutic targets [0.03%]
嗜酸性粒细胞的多样性与功能：亚型及治疗靶点的新见解
Faiz Ali Khan,Abhishek Raj,Hizbullah Khan et al.
Faiz Ali Khan et al.
Eosinophils are multifunctional polymorphonuclear granulocytes garnering attention for their roles in disease and maintaining physiological homeostasis. Historically, these immune cells were known to mediate allergic responses and defend ag...
Mohamed H Elbahoty,Brandon J Metge,Amr R Elhamamsy et al.
Mohamed H Elbahoty et al.
Despite substantial advances in early detection and therapeutic strategies, breast cancer remains a major cause of cancer-related morbidity and mortality worldwide. Changes in cytoskeletal proteins that typically regulate cellular architect...