Silencing of METTL16 protects granulosa cells from the cisplatin-induced ferroptosis in premature ovarian failure [0.03%]
Jing Xiong,Ling He,Yongjing Zhang et al.
Jing Xiong et al.
Premature ovarian failure (POF) and insufficiency induced by cisplatin are common complications associated with gynecological diseases. This study aims to investigate the role of N6-methyladenosine (m6A) methyltransferase METTL16 in cisplat...
Inhibition of RIPK1/RIPK3-MLKL inflammatory signaling pathway activation attenuates preterm birth [0.03%]
Xuexiang Bing,Yongqing Wang,Jiacui Zheng et al.
Xuexiang Bing et al.
Preterm birth (PTB) is a principal contributor to neonatal morbidity, wherein inflammation and dysregulated cell death pathways are implicated as key drivers in its pathogenesis. However, the role of the RIPK1/RIPK3-MLKL signaling axis, a c...
Tommaso Pagliarusco,Anais Franco-Romero,Francesca Terrin et al.
Tommaso Pagliarusco et al.
mytho (Macroautophagy and YouTH Optimizer) is a novel FoxO-dependent gene that has been recently identified to control health- and life-span in Caenorhabditis elegans via autophagy regulation. However, the role of this gene in tissues devel...
Nicotinamide N-methyltransferase as a therapeutic target in taxane-resistant castration-resistant prostate cancer [0.03%]
Buse Cevatemre,Ezgi Karyemez,Ipek Bulut et al.
Buse Cevatemre et al.
Drug resistance in patients remains a significant obstacle to successful treatment, even with improvements in cancer treatment strategies. Resistance to taxanes, such as docetaxel (Dtx) and cabazitaxel (Cbz), frequently emerges in castratio...
Lipid-anchored melanotransferrin mediates transferrin-independent iron uptake and ferritin storage in mammals [0.03%]
Mei Mei Tian,Jacqueline W C Tiong,Reinhard Gabathuler et al.
Mei Mei Tian et al.
Non-transferrin-bound iron (NTBI) transport constitutes a critical pathway for cellular iron uptake in the kingdom Animalia that remains mechanistically unresolved. Its physiological importance is underscored by atransferrinemia, a rare dis...
NAT10 promotes gallbladder cancer progression by remodeling cholesterol metabolism via PCSK9 mRNA acetylation [0.03%]
Zheng-Yu Chen,Ming-Yang Wang,Ben Ma et al.
Zheng-Yu Chen et al.
Gallbladder cancer (GBC) is a highly aggressive biliary tract tumor with a poor prognosis, underscoring the critical need for new therapeutic strategies. N-acetyltransferase 10 (NAT10), the sole writer of N4-acetylcytidine (ac4C), is upregu...
Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3 [0.03%]
Chenicheri Kizhakkeveettil Keerthana,Tennyson P Rayginia,Kalishwaralal Kalimuthu et al.
Chenicheri Kizhakkeveettil Keerthana et al.
Hepatocellular carcinoma (HCC) is a highly aggressive tumor with rapid propensity for extrahepatic metastasis, which critically limits long-term clinical benefits of conventional chemotherapeutics and decreases the overall survival rate of ...
Regulation of lipid droplets accumulation by the Hippo-YAP/COX2 signaling pathway in neomycin-induced ototoxicity [0.03%]
Wenli Hao,Song Gao,Suhan Guo et al.
Wenli Hao et al.
Lipid metabolism is an important biological process that maintains the dynamic balance of several key functions, such as intracellular energy metabolism, signal transduction, and membrane remodeling. However, the role of lipid metabolism in...
Dual inhibition of xCT and GGCT induces ferroptosis in glioblastoma cells by depleting cysteine and disrupting redox homeostasis [0.03%]
Masaya Mori,Hiromi Ii,Mai Matsumura et al.
Masaya Mori et al.
Glioblastoma is the most aggressive and treatment-resistant brain tumor. Ferroptosis, an iron-dependent form of regulated cell death caused by lipid peroxidation, has emerged as a promising therapeutic strategy; however, intrinsic resistanc...
Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins [0.03%]
Yuntian Duan,Masood Sepehrimanesh,Md Abir Hosain et al.
Yuntian Duan et al.
Childhood-onset DYT1 dystonia is a severe movement disorder caused by a heterozygous ΔE mutation in TOR1A, yet the molecular mechanisms driving disease remain unclear. The nuclear lamina, a key structural scaffold for nuclear integrity and...