Disruption of thrombospondin 1/2-integrin β1 axis impairs cell adhesion and tumor growth in intrahepatic cholangiocarcinoma [0.03%]
血小板源性生长因子-1/2-整合素β1轴在肝内胆管癌细胞粘附和肿瘤生长中的作用失调
Veronica Porreca,Ludovica Giancola,Luca Sallustio et al.
Veronica Porreca et al.
Elevated expression of THBS1 and THBS2 in intrahepatic cholangiocarcinoma (iCCA) contributes to tumor growth and metastatic dissemination. Both proteins are predominantly produced by cancer-associated fibroblasts (CAFs) and iCCA cells, enha...
Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death [0.03%]
靶向递送CLYBL干扰子的类血小板纳米颗粒通过富马酸受体重编程巨噬细胞来预防脓毒症引发的肺部细胞死亡
ZuoJun Huang,Jialin Zhong,Li Zhang et al.
ZuoJun Huang et al.
Excessive inflammation and metabolic dysregulation fuel alveolar cell death in sepsis-induced lung injury, yet effective molecular interventions are lacking. We identify citrate lyase beta-like (CLYBL) as a previously unrecognized metabolic...
BCL2 inhibition in acute and chronic pancreatitis - is there a therapeutic perspective? [0.03%]
急性及慢性胰腺炎中Bcl-2抑制的治疗前景？
Jacek J Litewka,Monika A Jakubowska,Wei Huang et al.
Jacek J Litewka et al.
Necrotic death of pancreatic acinar cells leads to premature activation of digestive enzymes and is a central driver of inflammation in acute pancreatitis (AP). In contrast, apoptosis is a non-lytic, regulated form of cell death that preven...
LRP2-mediated regulation of ferroptosis through the Wnt/β-catenin-GPX4 axis in colorectal cancer liver metastasis and chemoresistance [0.03%]
LRP2通过Wnt/β-catenin-GPX4轴调控结直肠癌肝转移和化疗耐药中的铁死亡
Shasha Zhao,Limei Sun,Jing Xia et al.
Shasha Zhao et al.
Colorectal cancer liver metastasis (CRLM) is a major contributor to cancer mortality, and therapeutic efficacy is often limited by chemoresistance. Dysregulated lipid metabolism has been implicated in tumor progression, yet the function of ...
Correction: ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration [0.03%]
校正：ELF1介导的METTL3/YTHDF2上调通过m６A依赖性下调E２F３mRNA促进椎间盘细胞衰老在椎间盘退变中的作用
Xiao-Wei Liu,Hao-Wei Xu,Shu-Bao Zhang et al.
Xiao-Wei Liu et al.
Published Erratum
Cell death discovery. 2026 May 29;12(1):257. DOI:10.1038/s41420-026-03153-4 2026
Correction: Misregulated alternative splicing in endometriosis: a role for aberrant mRNA variants in endometriotic cell growth [0.03%]
子宫内膜异位症中错误调控的可变剪接：异常mRNA变异体在子宫内膜异位细胞生长中的作用纠正通知
Venkata Naga Goutham Davuluri,Michelle Dias,Roxanna Llinas et al.
Venkata Naga Goutham Davuluri et al.
Published Erratum
Cell death discovery. 2026 May 29;12(1):258. DOI:10.1038/s41420-026-03154-3 2026
Inhibition of TGM2 enhances cisplatin sensitivity in MSH2-deficient bladder cancer [0.03%]
TGM2抑制可增强MSH2缺陷膀胱癌细胞中顺铂的敏感性
Wenjie Wei,Xingyuan Xiao,Chao Ren et al.
Wenjie Wei et al.
MSH2 (mutS homolog 2) gene, a key component of the DNA mismatch repair system, garners significant attention for its influence on cancer progression and prognosis. Loss of MSH2 protein decreases the chemosensitivity of bladder cancer (BCa) ...
Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma [0.03%]
HNF4α介导的蛋氨酸代谢激活可使肝细胞癌获得铁死亡抵抗性
Xiaolei Zhou,Zhenzhen Li,Libo Wang et al.
Xiaolei Zhou et al.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide. Ferroptosis induction represents a promising therapeutic strategy, but its efficacy is constrained by tumor heterogeneity, particularly the relati...
Reprogramming temozolomide response in glioblastoma through regulated and immunogenic cell death modalities [0.03%]
通过调控型和免疫原性细胞死亡方式重新编程胶质母细胞瘤对替莫唑胺的反应
Tatiana A Mishchenko,Oluwabukolami J Olajide,Ekaterina N Gorshkova et al.
Tatiana A Mishchenko et al.
Temozolomide (TMZ) resistance, driven by genetic, epigenetic, and tumor microenvironment factors, remains a significant barrier in glioblastoma (GBM) therapy. Immunogenic cell death (ICD) modalities (such as necroptosis, ferroptosis, pyropt...
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance [0.03%]
ATP2B4介导的染色质凝聚加重胰腺癌放疗抵抗性
Yuyu Luo,Wei Jiang,Yanfang Liu et al.
Yuyu Luo et al.
The intrinsic radio-resistance of pancreatic cancer cells significantly hinders therapeutic efficacy. However, the precise molecular mechanisms underlying this resistance remain inadequately understood and warrant further investigation. Her...