Polyethylene nano- and microplastics trigger metabolic stress responses in human vaginal epithelial cells [0.03%]
聚乙烯纳米和微塑料触发人类阴道上皮细胞代谢压力反应
Paola Pontecorvi,Matteo Cassandri,Alessandra Gianoncelli et al.
Paola Pontecorvi et al.
Nano- and microplastics (N/MPs) are emerging environmental contaminants increasingly detected in multiple human tissues, yet their biological effects remain poorly defined. The vaginal epithelium represents a relevant but largely unexplored...
Salinomycin as a death switch: how gastric cancer cells choose their demise [0.03%]
沙利度胺衍生物作为死亡开关：胃癌细胞凋亡与坏死的选择
Pasqualina Laurenziello,Margherita Luongo,Francesca Lospinoso Severini et al.
Pasqualina Laurenziello et al.
Gastric cancer (GC) remains a significant global health challenge due to the prevalence of multidrug resistance (MDR) that leads to therapy failure. MDR is driven by tumor heterogeneity and the presence of cancer stem cells (CSCs). Drug rep...
p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials [0.03%]
P63在皮肤稳态和疾病中的作用机制及治疗潜力
Yujia Cong,Zhenglin He,Hanming Hao et al.
Yujia Cong et al.
As a pivotal member of the p53 family, the p63 gene plays an indispensable role in skin homeostasis and development. The gene encodes multiple isoforms, primarily TAp63 and ΔNp63, which differentially regulate cell proliferation, different...
Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia [0.03%]
自噬抑制增强FLT3抑制剂的抗白血病作用并克服FLT3-ITD急性髓系白血病耐药性
Manuela Albuquerque de Melo,Brunno Gilberto Santos de Macedo,Diego A Pereira-Martins et al.
Manuela Albuquerque de Melo et al.
Autophagy induction has recently emerged as a mechanism of resistance to FLT3 inhibitors (FLT3i) in patients with FLT3-ITD mutant acute myeloid leukemia (AML). Here, we assessed the molecular mechanisms of autophagy inhibition associated wi...
MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway [0.03%]
MYCN通过破坏PKA信号通路抑制神经母细胞瘤细胞中TrkC介导的分化作用
Stephanie Maher,Andrew Roe,Kieran Wynne et al.
Stephanie Maher et al.
Neuroblastoma is a rare childhood cancer in which high-risk disease, frequently driven by MYCN amplification, has poor survival. Trk-receptor expression correlates with prognosis: TrkA is observed in low-risk cases while TrkB is often expre...
Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models [0.03%]
甲硫氨酸蛋白磷酸酶2A影响小鼠模型中α-突触核蛋白病的发展
Santhosh Maddila,Kambiz Hassanzadeh,Jun Liu et al.
Santhosh Maddila et al.
The accumulation of aggregated alpha-Synuclein (α-Syn) in Lewy bodies and Lewy neurites is a hallmark of Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB), and phosphorylation of α-Syn at Ser129 is a key pathological marker in ...
ATP6V1B2 alleviates hepatic steatosis by promoting lysosomal acidification in hepatocytes [0.03%]
ATP6V1B2通过促进肝细胞溶酶体酸化来缓解肝脏脂质蓄积
Ruizi Xu,Fuji Yang,Zhuan Zhang et al.
Ruizi Xu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common metabolic disorder characterized by the abnormal accumulation of fat in the liver. ATP6V1B2, an essential subunit of the vacuolar ATPase (V-ATPase) complex, plays ...
Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination [0.03%]
解密STAT3-PXN在GBM（IDH野生型）中的正反馈环：转录调控和抑制YB-1泛素化
Xiaodong Li,Hongyan Guo,Ziyi Liu et al.
Xiaodong Li et al.
Glioblastoma (GBM) is the most fatal primary brain malignancy in adults, with a median survival of approximately 15 months. The 2021 WHO classification redefined GBM as exclusively IDH-wildtype based on its characteristic molecular and clin...
Redox cycling nitroxide limits cellular iron availability and selectively inhibits iron-sulfur cluster metabolism [0.03%]
红氧循环硝酮限制细胞中铁的可用性并选择性抑制铁硫簇代谢
Erdem M Terzi,Kenji M Fujihara,Marte Molenaars et al.
Erdem M Terzi et al.
Iron-sulfur clusters (ISCs) are redox active cofactors for essential proteins with diverse functions. We demonstrate that Tempol, a redox cycling nitroxide, limits iron bioavailability in a manner distinct from iron chelators, mainly via it...
Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy [0.03%]
新辅助化疗后卵巢癌免疫微环境的动态变化特征研究
Mingjie Wu,Fei Lv,Yi Jin et al.
Mingjie Wu et al.
Standard treatment for advanced ovarian cancer involves initial surgery followed by platinum-based chemotherapy. Although most patients are sensitive, most relapses occur at a later stage, highlighting the urgent need to understand the tumo...