Anti-astmatic effect of ROCK inhibitor, GSK429286 A, in experimentally induced allergic airway inflammation [0.03%]
ROCK抑制剂GSK429286A对实验性过敏性气道炎症的抗哮喘作用
Eduard Gondáš,Jozef Mažerik,Matúš Dohál et al.
Eduard Gondáš et al.
Background: Allergic asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, inflammation and remodeling. ROCK inhibitors have now been shown to have the potential to alleviate these symptoms...
The global immune-nutrition-inflammation index (GINI) as a robust prognostic factor in glioblastoma patients treated with the standard stupp protocol [0.03%]
免疫营养炎症指数(GINI)作为标准Stupp方案治疗的胶质母细胞瘤患者的预后因素
Erkan Topkan,Nilufer Kilic Durankus,Sukran Senyurek et al.
Erkan Topkan et al.
Background: Systemic inflammation can significantly impact gliomas' onset, progression, and prognosis. Glioblastoma multiforme (GBM) represents the glioma subtype characterized by the most profound inflammatory and immuno...
Syk protein inhibitors treatment for the allergic symptoms associated with hyper immunoglobulin E syndromes: A focused on a computational approach [0.03%]
基于计算方法针对高免疫球蛋白E综合征相关过敏症状的Syk蛋白抑制剂治疗研究
Mariam Mansouri,Ghyzlane ElHaddoumi,Ilham Kandoussi et al.
Mariam Mansouri et al.
Background: Mutations in the Spleen tyrosine kinase (Syk) protein have significant implications for its function and response to treatments. Understanding these mutations and identifying new inhibitors can lead to more effective therapies f...
Implication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to COVID-19 [0.03%]
IL-12A、IL-12B、IL-6和TNF单核苷酸多态性在COVID-19易感性和严重程度中的作用
R Benmansour,M R Tagajdid,I A Lahlou et al.
R Benmansour et al.
Background: The Coronavirus Disease 2019 (COVID-19) pandemic has led to significant global morbidity and mortality. Understanding the genetic factors that influence disease outcomes can provide critical insights into path...
Probable drug-induced systemic reaction without blood eosinophilia and rash- utility of eosinophilic cationic protein for diagnosis [0.03%]
无白细胞和皮疹的药物诱导性全身反应的可能性-嗜酸性阳离子蛋白诊断价值的研究
Mairi Ziaka,Evangelia Liakoni,Ulrich Mani-Weber et al.
Mairi Ziaka et al.
Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway [0.03%]
视黄醇脱氢酶10通过PI3K/AKT途径促进脊髓胶质瘤上皮间质转化
Zijun Zhao,Zihan Song,Zairan Wang et al.
Zijun Zhao et al.
Background: Spinal cord glioma (SCG), a rare subset of central nervous system (CNS) glioma, represents a complex challenge in neuro-oncology. There has been research showing that Retinol Dehydrogenase 10 (RDH10) may be a tumor promoting fac...
Icariin protects testicular damage in streptozotocin-induced diabetic rats through regulation of glycolysis pathway [0.03%]
淫羊藿次黄酮通过调节糖酵解途径保护链脲佐菌素诱导的糖尿病大鼠睾丸损伤
Fang Liu,Biyun Liao,Yan-Lan Ling et al.
Fang Liu et al.
Objective: This study aims to investigate potential beneficial actions of icariin (ICA) on testicular spermatogenic function in male rats with streptozotocin (STZ)-induced diabetes and to explore the underlying mechanisms...
Risk factors and a model for prognosis prediction after intravenous thrombolysis with alteplase in acute ischemic stroke based on propensity score matching [0.03%]
基于倾向性评分匹配的阿替普酶静脉溶栓治疗急性缺血性卒中的预后预测模型及危险因素分析
Pan Huang,XingYang Yi
Pan Huang
Background: Alteplase intravenous thrombolysis is effective for treating acute ischemic stroke (AIS) within 4.5 h. Nevertheless, the prognosis remains poor for some patients.Objective: To investigate the risk factors for poor prognosis in p...
Immunomodulatory effects of the induced pluripotent stem cells through expressing IGF-related factors and IL-10 in vitro [0.03%]
体外诱导多能干细胞通过表达胰岛素样生长因子相关因子和IL-10发挥免疫调节作用
Paria Bayati,Marjan Taherian,Nazanin Mojtabavi
Paria Bayati
Background: Induced Pluripotent Stem Cells (IPSCs) represent an innovative strategy for addressing challenging diseases, including various rheumatologic conditions. Aside from their regenerative capacities, some studies h...