Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice [0.03%]
asiatic酸通过抑制NF-κB信号通路改善小鼠急性及慢性的结肠炎作用机制研究
Seona Park,Hyun Jung Lee,Seong-Joon Koh et al.
Seona Park et al.
Objective: This study aimed to elucidate the anti-inflammatory mechanisms of asiatic acid (AA) by focusing on its modulation of the nuclear factor-κB (NF-κB) signaling pathway and to evaluate its therapeutic effects in ...
Pre-activation status impacts regenerative potential of oligodendrocyte progenitors in an LPS-exposed animal model [0.03%]
预先激活状态影响内毒素暴露动物模型中少突胶质前体细胞的再生潜能
Farzaneh Rezaei Yazdi,Parichehr Pasbakhsh,Hoda Akbari et al.
Farzaneh Rezaei Yazdi et al.
Introduction & aims: Optimal neural activity in the central nervous system relies on the myelin sheath formed by oligodendrocytes. During demyelination, changes in the microenvironment can activate oligodendrocyte precurs...
Translation element EIF4A1 is a potential divergent immune biomarker between colon cancer and rectal cancer [0.03%]
翻译元件EIF4A1是结肠癌和直肠癌之间潜在的免疫差异生物标志物
Zhenpeng Zhu,Peng Wang,Chenyang Hou et al.
Zhenpeng Zhu et al.
Objective: Given the global high incidence of colorectal cancer (CRC) and the need for subtype-specific molecular targets, this study aims to investigate the role and therapeutic potential of EIF4A1 in colon and rectal ca...
Intravenous immunoglobulins in Henoch-Schönlein purpura with severe gastrointestinal involvement. Case report and review of the literature [0.03%]
重症胃肠受累的亨诺赫-许恩旦综合征的静脉用免疫球蛋白治疗：1例报告及文献复习
Marco Pappalardo,Lucrezia Passadore,Marco Manfredi et al.
Marco Pappalardo et al.
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children. It often follows a viral infection. Although it is a self-limiting disease, various acute, and chronic complications can occur. We describe a case of a 6-ye...
Role of β and α1-adrenoceptors in pancreatic regulation of glucose homeostasis, apoptosis, and fibrosis in dexamethasone-treated rats: A new insight into β-arrestin2 crosstalk with cAMP, PKA-ERK1/2-CREB, and PKB-FOXO1 signaling pathways [0.03%]
β和α1肾上腺素受体在地塞米松诱导的大鼠胰岛调节葡萄糖稳态、细胞凋亡及纤维化中的作用：一个新的β-arrestin2信号交叉途径与cAMP，PKA-ERK1/2-CREB以及PKB-FOXO1通路的洞察
Nehal S Wahba,Ahmed Abdelfattah-Hassan,Dalia A Hemead et al.
Nehal S Wahba et al.
Objective: The current study aimed to investigate the role of β and α1-adrenoceptors in pancreatic regulation of glucose homeostasis, apoptosis, and fibrosis in a rat model of dexamethasone-induced insulin resistance. ...
Flow cytometry-based evaluation of CD4/CD25 and IL-17 expression in sepsis of cancer surgical patients [0.03%]
癌症手术患者脓毒症的CD4/CD25及IL-17表达的流式细胞术分析
Ahmed Samir Abdelhafiz,Asmaa Ali,Walaa Y Elsabeeny et al.
Ahmed Samir Abdelhafiz et al.
Introduction and objectives: Sepsis is a critical, life-threatening condition marked by organ dysfunction. Patients undergoing surgery for cancer are especially susceptible, facing a significantly increased risk compared ...
Identification of prognostic biomarkers for hepatocellular carcinoma based on the m6A RNA modification [0.03%]
基于m6A RNA修饰的肝细胞癌预后生物标志物识别
Jiachun Sun,Ziyi Xu,Yitao Fan et al.
Jiachun Sun et al.
The objective of this study was to identify the prognostic biomarkers for hepatocellular carcinoma (HCC) by analyzing the N6-methyladenosine (m6A) RNA modification. HCC is a complex malignant tumor induced by various pathogenic factors. m6A...
Molecular characterization and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus in immunocompromised cancer patients [0.03%]
免疫缺陷癌症患者中耐甲氧西林金黄色葡萄球菌的分子特征及抗生素敏感性研究
Samah Radwan,Dalia Y Kadry,Rana Hamdy et al.
Samah Radwan et al.
Objective: This study aims to analyze MRSA isolates from pediatric cancer patients, determine the prevalence of PVL genes and assess their clinical implications. ...
Halofuginone induces ERK phosphorylation and synergizes with trametinib in gastric cancer cells [0.03%]
Halofuginone诱导ERK磷酸化并能与曲马替尼协同作用抑制胃癌细胞生长
Yuemin Sun,Peng Wang,Xiaofeng Bai et al.
Yuemin Sun et al.
Objective: The aim of this study was to investigate the effects of halofuginone (HF) on gastric cancer cells and whether the combination of HF and trametinib has synergistic effects. ...