A new way of the Coombs test using flow cytometry-based assay to assess erythrocytes-bound IgG antibodies in the human and rabbit model [0.03%]
一种新的库姆斯试验方法：采用流动式细胞分析法评估人和兔模型红细胞结合的免疫球蛋白G抗体的新途径
Anwar Ullah,Xuewei Ding,Xia Qi et al.
Anwar Ullah et al.
The Coombs test is important in hematology for detecting erythrocyte-bound IgG antibodies or in serm through agglutination methods, but its sensitivity and specificity are limited. Flow cytometry provides a more precise and sensitive altern...
Ghulam Rasool,Waqas Ahmed Khan,Arif Muhammad Khan et al.
Ghulam Rasool et al.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes acute coronavirus disease-19 (COVID-19) that has emerged on a pandemic level. Coronaviruses are well-known to have a negative impact on the lungs and cardiovascular sy...
Hesperidin ameliorates thioacetamide-induced liver fibrosis via antioxidative and anti-inflammatory mechanisms targeting TGF-β/α-SMA pathways in rats [0.03%]
柚皮素通过抗氧化和抗炎作用以及靶向TGF-β/α-SMA途径改善大鼠硫乙醇酸诱导的肝纤维化
Aya Megahed,Hossam Gadalla,Waheed A Filimban et al.
Aya Megahed et al.
Our study intended to explore Hesp antioxidant and anti-inflammatory effects against TAA hepatic fibrosis in rats. Hesperidin (Hesp), is a pharmacologically active flavonoid, found abundantly in citrus species. Our present research attempts...
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis [0.03%]
姜黄素通过调节EGFR/Src信号轴抑制骨肉瘤细胞转移、浸润和增殖
Huiying Liu,Zhiqiang Li,Binwu Xu et al.
Huiying Liu et al.
We explored the biological mechanisms by which curcumin (Cur) confronts osteosarcoma (OS) tumorigenesis and potential drug gene targets based on network pharmacology and in vitro cell experiments. Cur has been recognized for its significant...
Progress of research into microglial mediation of central post-stroke pain [0.03%]
微胶质细胞在中枢性卒中痛发病机制中的作用研究进展
Yue-Rong Li,Zhao-Hui Dang,Shan-Shan Li et al.
Yue-Rong Li et al.
Central post-stroke pain (CPSP) is a chronic neuropathic pain syndrome that commonly occurs after cerebral stroke, and it severely impairs the daily activities of stroke patients. A number of fundamental and clinical studies support the the...
Use of CRP/lymphocyte ratio as a predictor of treatment selection and mortality in COVID-19 patients in the intensive care unit [0.03%]
C反应蛋白/淋巴细胞比值在预测新冠病毒肺炎重症患者治疗选择和死亡率中的作用
Efraim Guzel,Burak Mete,Oya Baydar Toprak et al.
Efraim Guzel et al.
This study primarily aimed to examine the significance of the C-reactive protein to lymphocyte ratio (CLR), a key marker of inflammation, in relation to the disease progression and management of COVID-19 patients admitted to the intensive c...
Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis [0.03%]
Phillygenin通过调节PI3K/Akt/mToR信号通路抢救急性重症胰腺炎大鼠受损的自噬流功效研究
Jiaxing Li,Jiming Duan,Yiwen Sun et al.
Jiaxing Li et al.
To investigate the mechanism of pancreatic alveolar cell autophagy in rats with severe acute pancreatitis (SAP) by phillygenin (PHI) based on the PI3K/Akt/mToR pathway. Rats were randomly divided into control group (CON group), SAP model gr...
Coexistence of tubulocystic renal cell carcinoma and polycythemia vera: A rare case report [0.03%]
管状囊性肾细胞癌合并红细胞增多症一例罕见病例报告
Renjie Wei,Fudong Liu,Xu Luo et al.
Renjie Wei et al.
Tubulocystic Renal Cell Carcinoma (TC-RCC) and Polycythemia Vera (PV) are both infrequent medical conditions. TC-RCC was recognized as a distinct subtype of kidney cancer by the World Health Organization in 2016, while PV is a rare myelopro...
Calcitriol ameliorates cisplatin-induced hepatorenal toxicity via regulation of Nrf2-Mrp2/p38 MAPK signaling in mice [0.03%]
骨化三醇通过调节Nrf2-Mrp2/p38MAPK信号通路改善小鼠顺铂引起的肝肾毒性
Mohamed A Morsy,Rania Abdel-Latif,Manar Fg Ibrahim et al.
Mohamed A Morsy et al.
Despite being one of the most frequently used chemotherapy agents, cisplatin exhibits substantial hepatorenal injury by triggering oxidative stress, inflammation, and apoptosis pathways. The current investigation studied the possible protec...
Adverse reactions of immune checkpoint inhibitors combined with angiogenesis inhibitors: A pharmacovigilance analysis of drug-drug interactions [0.03%]
免疫检查点抑制剂与抗血管生成抑制剂相互作用的药物警戒分析及不良反应研究
Xiayang Ren,Lei Deng,Xin Dong et al.
Xiayang Ren et al.
The combination of immune checkpoint inhibitors (ICIs) and angiogenesis inhibitors (AGIs) is widely used in cancer treatment; however, drug-drug reactions (DDIs) remain unknown. We aimed to identify interaction signals for the concomitant u...