Use of CRP/lymphocyte ratio as a predictor of treatment selection and mortality in COVID-19 patients in the intensive care unit [0.03%]
C反应蛋白/淋巴细胞比值在预测新冠病毒肺炎重症患者治疗选择和死亡率中的作用
Efraim Guzel,Burak Mete,Oya Baydar Toprak et al.
Efraim Guzel et al.
This study primarily aimed to examine the significance of the C-reactive protein to lymphocyte ratio (CLR), a key marker of inflammation, in relation to the disease progression and management of COVID-19 patients admitted to the intensive c...
Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis [0.03%]
Phillygenin通过调节PI3K/Akt/mToR信号通路抢救急性重症胰腺炎大鼠受损的自噬流功效研究
Jiaxing Li,Jiming Duan,Yiwen Sun et al.
Jiaxing Li et al.
To investigate the mechanism of pancreatic alveolar cell autophagy in rats with severe acute pancreatitis (SAP) by phillygenin (PHI) based on the PI3K/Akt/mToR pathway. Rats were randomly divided into control group (CON group), SAP model gr...
Coexistence of tubulocystic renal cell carcinoma and polycythemia vera: A rare case report [0.03%]
管状囊性肾细胞癌合并红细胞增多症一例罕见病例报告
Renjie Wei,Fudong Liu,Xu Luo et al.
Renjie Wei et al.
Tubulocystic Renal Cell Carcinoma (TC-RCC) and Polycythemia Vera (PV) are both infrequent medical conditions. TC-RCC was recognized as a distinct subtype of kidney cancer by the World Health Organization in 2016, while PV is a rare myelopro...
Calcitriol ameliorates cisplatin-induced hepatorenal toxicity via regulation of Nrf2-Mrp2/p38 MAPK signaling in mice [0.03%]
骨化三醇通过调节Nrf2-Mrp2/p38MAPK信号通路改善小鼠顺铂引起的肝肾毒性
Mohamed A Morsy,Rania Abdel-Latif,Manar Fg Ibrahim et al.
Mohamed A Morsy et al.
Despite being one of the most frequently used chemotherapy agents, cisplatin exhibits substantial hepatorenal injury by triggering oxidative stress, inflammation, and apoptosis pathways. The current investigation studied the possible protec...
Adverse reactions of immune checkpoint inhibitors combined with angiogenesis inhibitors: A pharmacovigilance analysis of drug-drug interactions [0.03%]
免疫检查点抑制剂与抗血管生成抑制剂相互作用的药物警戒分析及不良反应研究
Xiayang Ren,Lei Deng,Xin Dong et al.
Xiayang Ren et al.
The combination of immune checkpoint inhibitors (ICIs) and angiogenesis inhibitors (AGIs) is widely used in cancer treatment; however, drug-drug reactions (DDIs) remain unknown. We aimed to identify interaction signals for the concomitant u...
Prognostic impact of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in Egyptian breast cancer patients [0.03%]
基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)对埃及乳腺癌患者的预后影响
Fayrouz A Fouad,Mohamed A Khali,Inas Moaz et al.
Fayrouz A Fouad et al.
This study aims to investigate the diagnostic and prognostic relevance of MMP-2 and MMP-9 as biomarkers for breast cancer, as well as their association with clinicopathological factors. Breast cancer is a leading contributor to cancer-relat...
Effects of antioxidants on skin hydration, inflammatory cytokines, and keratinocyte differentiation markers in a PM10-exposed skin barrier-disrupted mouse model [0.03%]
抗氧化剂对PM10暴露的皮肤屏障受损小鼠模型中皮肤含水量、炎症细胞因子和角质形成细胞分化标志物的影响
Jin Ho Kim,Mi Hee Kwack,Weon Ju Lee
Jin Ho Kim
Given that particulate matter (PM) has an established role in inducing oxidative stress, inflammation, and skin aging, it is plausible that PM could exacerbate inflammatory skin conditions such as xerosis. Xerosis represents a significant d...
Pediatric IgG4-related dacryoadenitis and sialadenitis (Mikulicz's disease) with acquired hemophilia A: A case report and review of literature [0.03%]
IgG4相关性儿童泪腺和唾液腺炎（ Mikulich病）合并获得性血友病A：病例报告及文献复习
Cong Mai Thanh,Khuyen Nguyen Thi,Hiep Nguyen Canh et al.
Cong Mai Thanh et al.
We report a case of IgG4-related dacryoadenitis and sialadenitis (Mikulicz's disease) with acquired hemophilia A (AHA) in a pediatric patient. An 11-year-old female presented with intermittent swelling of the bilateral upper eyelids and nec...
Treatment of systemic sclerosis complicated with pyoderma gangrenosum with adalimumab: A case report of a rare disease [0.03%]
阿达木单抗治疗系统性硬化症合并坏死性暗疮1例报告
Chengqiang Ren,Cheng Yu,Maoquan Zhang et al.
Chengqiang Ren et al.
Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic dermatosis characterized by recurrent, painful ulcers that commonly affect the lower extremities but can also involve other parts of the body. Over half of patients with PG have...
The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway [0.03%]
虾青素对辐照小鼠脾脏影响的性别差异：STING、TLR4和mTOR相关通路参与响应
Maha M Aziz,Marwa M El-Sheikh,Marwa A Mohamed et al.
Maha M Aziz et al.
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence. ...