Construction of a tumor immune microenvironment-related risk scoring model for prognosis of hepatocellular carcinoma [0.03%]
肝细胞癌预后相关肿瘤免疫微环境风险评分模型的建立
Xinyi Li,Zifan Qin,Haozhi Chen et al.
Xinyi Li et al.
Objective: This study aims to develop a prognostic model for HCC based on TME-related factors. Introduction: Hepatocellular carcinoma (...
Pan-cancer multi-omics analysis to identify the potential pro-oncogenic properties of GREM1 as a promising targets for cancer prognosis and therapeutics [0.03%]
泛癌多组学分析识别GREM1促致癌特性及其作为癌症预后和治疗靶点的潜力
Menglu Zhu,Hengli Zhou,Yue Zhuo et al.
Menglu Zhu et al.
We aimed to investigate the potential pro-oncogenic properties of GREM1 by Pan-cancer multi-omics analysis. Accumulating evidence has highlighted that GREM1 (Gremlin 1), serves as an inhibitor of BMP (Bone Morphogenetic Protein) family, inv...
Immune-related adverse events-pembrolizumab-induced colitis-the importance of early diagnosis and treatment: A case report and review of the literature [0.03%]
免疫相关不良事件-帕博利珠单抗诱导的结肠炎-早期诊断和治疗的重要性：病例报告及文献回顾
Marina Markovic,Danijela Niciforovic,Violeta Mladenovic et al.
Marina Markovic et al.
Immune Checkpoint Inhibitors (ICIs) are monoclonal antibodies that block inhibitory immune targets, such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), and programmed death ligand 1 (PD-L). Pembrolizum...
Causal association between type 1 diabetes and autoimmune cholestasis: A bi-directional Mendelian randomized study [0.03%]
1型糖尿病和自身免疫性胆汁淤积症之间的因果关系：双向孟德尔随机化研究
Yuanda Liu,Lanlan Chen,Wei Hao et al.
Yuanda Liu et al.
Explore the causal relationship of risk between type 1 diabetes and primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). A causal association between type 1 diabetes and autoimmune liver disease remains ambiguous. Thi...
Pharmacovigilance study of immunomodulatory drug-related adverse events using spontaneous reporting system databases [0.03%]
基于自发呈报系统的免疫调节剂相关不良事件的药物警戒研究
Satoshi Nakao,Mika Maezawa,Moe Yamashita et al.
Satoshi Nakao et al.
The aim of this study was to evaluate the country-specific reporting status profile of immunomodulatory drugs (IMiDs)-related adverse events (ImrAEs) in real-world clinical practice, using data from the Japanese Adverse Drug Event Report (J...
Iron chelating, antioxidant and anti-apoptotic activities of hesperidin and/or rutin against induced-ferroptosis in heart tissue of rats [0.03%]
柚皮素和/或芸香素对大鼠心脏组织诱导铁死亡的螯合、抗氧化和抗凋亡作用
Haidy A Abdullah,Fatma Sm Moawed,Esraa Sa Ahmed et al.
Haidy A Abdullah et al.
Excess iron has been associated with cardiovascular diseases. Flavonoids are antioxidants and cardioprotectants. Therefore, the goal of the current study is to evaluate the anti-apoptotic, antioxidant, and iron-chelating qualities of two fl...
Construction and evaluation of glucocorticoid dose prediction model based on genetic and clinical characteristics of patients with systemic lupus erythematosus [0.03%]
基于系统性红斑狼疮患者遗传及临床特征的糖皮质激素剂量预测模型的构建和评估
Xin Luo,Jinjun Zhao,Danfeng Zou et al.
Xin Luo et al.
Currently, no glucocorticoid dose prediction model is available for clinical practice. This study aimed to utilise machine learning techniques to develop and validate personalised dosage models. Participants were patients with SLE who were ...
FGF19 is a biomarker associated with prognosis and immunity in colorectal cancer [0.03%]
FGF19是与结直肠癌预后和免疫相关的生物标志物
Peng Wang,Zhenpeng Zhu,Chenyang Hou et al.
Peng Wang et al.
Objective: This study aimed to investigate the relationship between fibroblast growth factor 19 (FGF19) and the prognosis and immune infiltration of colorectal cancer (CRC) and identify the related genes and pathways infl...
Comprehensive Pan-cancer Analysis Revealed CASP10 As a Promising Biomarker For Diverse Tumor Types [0.03%]
全面的泛癌分析揭示了CASP10作为多种肿瘤类型潜在生物标志物的价值
Qian Wang,Yaping Jiang,Weijia Liao et al.
Qian Wang et al.
We aimed to explore the comprehensive cancer landscape of Caspase-10 (CASP10). CASP10, a member of the caspase family, is located at the human chromosome locus 2q33-34. Studies have suggested its potential role in the development of certain...