Administration of anti-GFAP antibodies increases CGRP expression and increases pain hypersensitivity in spinal cord injured animals [0.03%]
抗GFAP抗体的管理增加了脊髓损伤动物中CGRP的表达和疼痛超敏反应
Georgene W Hergenroeder,Samuel T Molina,Juan J Herrera
Georgene W Hergenroeder
Background: Spinal cord injury (SCI) results in a multitude of cellular and pathological changes including neuronal loss, axonal damage, gliosis, and loss of motor and sensory function. In 40%-70% of patients, SCI can als...
Association of HLA-DR, HLA-DQ, and HLA-B alleles with inclusion body myositis risk: A systematic review, a meta-analysis, a meta-regression and a trial sequential analysis [0.03%]
与包涵体肌炎风险相关的HLA-DR、HLA-DQ和HLA-B等位基因：系统评价、荟萃分析、荟萃回归和试验序贯分析
Tarak Dhaouadi,Awatef Riahi,Taïeb Ben Abdallah et al.
Tarak Dhaouadi et al.
Introduction: Although, several studies have assessed the association of HLA Class I and II genes with inclusion body myositis (IBM), results were inconsistent and between-studies heterogeneity needs to be investigated. ...
Therapeutic drug monitoring and immunogenetic factors associated with the use of adalimumab in Crohn's disease patients [0.03%]
使用英夫利昔单抗治疗的克罗恩病患者的治疗药物监测和免疫遗传因素
Livia Moreira Genaro,Juliana Carron,Marina Moreira de Castro et al.
Livia Moreira Genaro et al.
Crohn's disease (CD) involves immune system interactions with intestinal tissue, driven by pro-inflammatory cytokines like Tumor Necrosis Factor (TNF-α). Adalimumab, targeting TNF-α, regulates associated inflammatory responses. Despite be...
Micronutrient deficiencies in patients with celiac disease: A systematic review and meta-analysis [0.03%]
乳糜泻患者中的微量营养素缺乏：系统回顾与荟萃分析
Saad Lamjadli,Ider Oujamaa,Ikram Souli et al.
Saad Lamjadli et al.
This study aimed to characterize micronutrient deficiencies, including iron, ferritin, folic acid, vitamin D, zinc (Zn), vitamin B12, and copper, in patients with celiac disease, and evaluated the effects of these deficiencies on selected h...
Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling [0.03%]
褪黑素通过Keap1/Nrf2信号传导减轻口腔上皮细胞炎症
Nan Zhang,Wenjing Wang,Rongxia Zhang et al.
Nan Zhang et al.
Background: Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide. Obje...
Meryem Fakhkhari,Ikram Salih,Khaoula Errafii et al.
Meryem Fakhkhari et al.
Objective: This meta-analysis aims to systematically evaluate the associations of four specific Single Nucleotide Polymorphisms (SNPs)-rs712829, rs712830, rs11568315, and rs884225-located in the promoter, intronic, and 3'...
INF-γ/TGF-β1-primed umbilical cord mesenchymal stem cells boost the T-lymphocytes activity: Modulation of CD25 expression and IL-6 secretion [0.03%]
INF-γ/TGF-β1预处理的脐带间充质干细胞促进T淋巴细胞活性：CD25表达和IL-6释放的调控作用
Abdulrahman H Almaeen,Heba M Saad-Eldien,Hala Gabr
Abdulrahman H Almaeen
Background: Mesenchymal stromal/stem cells (MSCs) have potent immunomodulatory abilities, particularly in a milieu of hyperactive immune system, through secreting a number of cytokines, growth factors, bioactive compounds...
Myricetin enhances keratinocytes differentiation via TRPV4 channel activation in mouse primary keratinocytes [0.03%]
芦丁通过激活TRPV4通道促进小鼠原代角质形成细胞的分化
Jie-Fang Gao,Tong-Xuan Li,Guo-Qiang Zhang
Jie-Fang Gao
The skin serves as the primary defensive barrier of the human body against external stimuli and damage. Keratinocytes, which are the predominant cell type in the human epidermis, undergo a differentiation process that is crucial for the for...
Aurora-A promotes lenvatinib resistance experimentally through hsa-circ-0058046/miR-424-5p/FGFR1 axis in hepatocellular carcinoma [0.03%]
环状RNA has-circ-0058046通过Aurora-A/miR-424-5P/FGFR1轴促进肝癌细胞获得仑伐替尼耐药性
Mubalake Abudoureyimu,Ni Sun,Weiwei Chen et al.
Mubalake Abudoureyimu et al.
Objective: This study aimed to investigate whether the dysregulation of Aurora-A is involved in lenvatinib resistance in hepatocellular carcinoma. Methods...
Rapamycin ameliorates inflammatory pain via recovery of autophagy flux mediated by mammalian target of rapamycin (mTOR) signaling pathway in the rat spinal cord [0.03%]
雷帕霉素通过调节脊髓中哺乳动物雷帕霉素靶点信号通路介导的自噬流恢复缓解炎性痛
Jiawei Zhang,Shi Chen,Rongyi Zhang et al.
Jiawei Zhang et al.
Objective: This study aimed to investigate the effect of rapamycin on inflammatory pain in rats. Introduction: Inflammatory pain is a k...