Iron chelating, antioxidant and anti-apoptotic activities of hesperidin and/or rutin against induced-ferroptosis in heart tissue of rats [0.03%]
柚皮素和/或芸香素对大鼠心脏组织诱导铁死亡的螯合、抗氧化和抗凋亡作用
Haidy A Abdullah,Fatma Sm Moawed,Esraa Sa Ahmed et al.
Haidy A Abdullah et al.
Excess iron has been associated with cardiovascular diseases. Flavonoids are antioxidants and cardioprotectants. Therefore, the goal of the current study is to evaluate the anti-apoptotic, antioxidant, and iron-chelating qualities of two fl...
Construction and evaluation of glucocorticoid dose prediction model based on genetic and clinical characteristics of patients with systemic lupus erythematosus [0.03%]
基于系统性红斑狼疮患者遗传及临床特征的糖皮质激素剂量预测模型的构建和评估
Xin Luo,Jinjun Zhao,Danfeng Zou et al.
Xin Luo et al.
Currently, no glucocorticoid dose prediction model is available for clinical practice. This study aimed to utilise machine learning techniques to develop and validate personalised dosage models. Participants were patients with SLE who were ...
FGF19 is a biomarker associated with prognosis and immunity in colorectal cancer [0.03%]
FGF19是与结直肠癌预后和免疫相关的生物标志物
Peng Wang,Zhenpeng Zhu,Chenyang Hou et al.
Peng Wang et al.
Objective: This study aimed to investigate the relationship between fibroblast growth factor 19 (FGF19) and the prognosis and immune infiltration of colorectal cancer (CRC) and identify the related genes and pathways infl...
Comprehensive Pan-cancer Analysis Revealed CASP10 As a Promising Biomarker For Diverse Tumor Types [0.03%]
全面的泛癌分析揭示了CASP10作为多种肿瘤类型潜在生物标志物的价值
Qian Wang,Yaping Jiang,Weijia Liao et al.
Qian Wang et al.
We aimed to explore the comprehensive cancer landscape of Caspase-10 (CASP10). CASP10, a member of the caspase family, is located at the human chromosome locus 2q33-34. Studies have suggested its potential role in the development of certain...
Interleukin expression patterns and immune cell infiltration in prostate adenocarcinoma: Implications for recurrence risk [0.03%]
前列腺腺癌中的白细胞介素表达模式和免疫细胞浸润：对复发风险的影响
Jialong Zhang,Cong Huang,Xu Wang et al.
Jialong Zhang et al.
Objective: This study aims to comprehensively investigate the expression profiles of interleukins in prostate adenocarcinoma (PRAD) and their relationship with immune cell infiltration, tumor progression, and patient prog...
Dihydromyricetin improving myocardial function in the mice induced by CCl4 [0.03%]
白鲜素改善四氯化碳诱导的小鼠心肌功能
Wen-Juan Zhang,Ke-Yun Li,Le-Ying Lin et al.
Wen-Juan Zhang et al.
Objective: To study the role and underlying mechanisms of dihydromyricetin on the myocardial function in mice induced by CCl4. Methods: ...
Impact of tacrolimus on interferon gamma ELISpot assay results for the assessment of T-cell immunity: Proof-of-concept [0.03%]
他克莫司对干扰素γELISpot检测结果的影响：评估T细胞免疫的概念性验证
Aurélie Truffot,Jules Weinhard,Pauline Dessaud et al.
Aurélie Truffot et al.
SOT patients require immunosuppressors to avoid graft rejection. Therapeutic drug monitoring is insufficient to find the optimal balance with immunosuppression. The evaluation of cell-mediated immunity by enzyme-linked immunospot (ELISpot) ...
Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer [0.03%]
结肠癌中cGAS/STING的表达与衰老相关特征之间的不关联性
Sofian Al Shboul,Ola Abu Al Karsaneh,Moath Alrjoub et al.
Sofian Al Shboul et al.
Objective: The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introdu...
Attenuation of senile pruritus by PAC-14028-mediated downregulation of the NF-κB and MAPK pathways [0.03%]
通过PAC-14028介导的NF-κB和MAPK通路下调来减轻老年性瘙痒症
Ji Hye Yoon,Byoung Young Woo,Mi-Yeon Kim et al.
Ji Hye Yoon et al.
Objective: Senile pruritus is a specific type of itching that occurs in elderly persons. Previously, we assessed antagonism of the nonselective ligand-gated cation channel transient receptor potential vanilloid 1 (TRPV1; ...