Blocking leukotriene receptors improve experimentally induced gastric ulcers in rats by inhibiting inflammation and apoptosis [0.03%]
白三烯受体阻断剂通过抑制炎症和细胞凋亡改善实验性胃溃疡
Hanan M Hassan,Alaa Bagalagel,Reem Diri et al.
Hanan M Hassan et al.
To investigate whether obstructing the cysteinyl leukotriene receptor-1 (CYSLTR1) with zafirlukast diminishes experimentally induced gastric ulcer (GU) in rats by modulating inflammation and apoptosis. Gastric ulcers affect approximately 10...
High expression of CCL3/CCL4/CCL5/CCR5 promotes exhausted CD8+ T cells terminal differentiation and is associated with poor prognosis in pediatric B-ALL patients [0.03%]
CCL3/CCL4/CCL5/CCR5高表达促进儿童B-急淋患者耗竭性CD8+T细胞向终末分化并与预后不良相关
Jiamian Zheng,Yupei Zhang,Xueting Peng et al.
Jiamian Zheng et al.
This study aims to identify differentially upregulated ligand-receptor interactions between B-ALL cells and exhausted CD8+ T cells and to develop a multivariate Cox regression model for predicting the overall survival of pediatric B-ALL pat...
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice [0.03%]
cucurbitacin B通过抑制janus激酶/信号转导子和转录激活子通路而抑制th17细胞分化并减轻小鼠胶原诱导的关节炎
Shu-Ping Kung,Hira Umbreen,Jou-Hsuan Wang et al.
Shu-Ping Kung et al.
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited treatment options and associated side effects or resistance. This study aims to investigate the therapeutic potential of the natural compou...
MicroRNA-21-5p regulates autophagy and apoptosis via the activation of the PI3K/AKT/mTOR signaling pathway and reducing H2O2-induced damage in primary AEC-II [0.03%]
miR-21-5p通过激活PI3K/Akt/mTOR信号通路和减少H2O2诱导的损伤来调节自噬和凋亡
Xinxin Liu,Qiuyu Dai,Jie Zheng et al.
Xinxin Liu et al.
Objective: We examined whether miR-21-5p activates the PI3K/AKT/mTOR signaling pathway, thereby inhibiting autophagy and apoptosis induced by H2O2 in AEC II cells. ...
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7 [0.03%]
GNF-5837通过上调谷胱甘肽过氧化物酶7缓解椎间盘老化
Yangkai Xu,Rongsheng Chen,Yan Zhuang et al.
Yangkai Xu et al.
Objective: The aim of this study was to investigate the role of glutathione peroxidase 7 (GPX7) in mitigating oxidative stress-induced cellular ageing and its contribution to intervertebral disc degeneration (IVDD). ...
Evaluation of immune checkpoint inhibitor-associated hepatotoxic adverse events: A pharmacovigilance analysis based on the FAERS database [0.03%]
基于FAERS数据库的免疫检查点抑制剂相关肝毒性不良事件的评价研究
Zhihong Chen,Junwei Zhang,Lei Zhang et al.
Zhihong Chen et al.
Objective: To investigate the comprehensive landscape of hepatotoxic adverse events (AEs) associated with immune checkpoint inhibitors (ICIs), with a special focus on evaluating the potential risk of lethal hepatotoxic AE...
Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury [0.03%]
CitH3和S100A8/A9协同抑制：缓解脓毒症诱导的炎症和肺损伤的新策略
Tao Dong,Wenlu Ouyang,Xin Yu et al.
Tao Dong et al.
Objective: Sepsis is a life-threatening condition with high global morbidity and mortality. Citrullinated histone H3 (CitH3) has gained recognition as a significant biomarker for early sepsis diagnosis and management. Thi...
Chemotherapy elevates cell surface PD-L1 and MHC-I expression in apoptotic gastric cancer cells [0.03%]
化疗通过提高胃癌细胞表面的PD-L1和MHC-I表达诱导凋亡抗原的产生
You-Syuan Lou,Xu-Chen Liu,Chih-Cheng Cheng et al.
You-Syuan Lou et al.
Background: The programmed cell death-ligand 1 (PD-L1) combined positive score is used as a patient selection tool and predictive factor for anti-programmed cell death-1 (PD-1)/PD-L1 therapy in gastric cancer. However, th...
Integrative analysis of crosstalk genes and diagnostic biomarkers in lupus-associated osteoporosis [0.03%]
系统性红斑狼疮相关骨质疏松的对话基因及诊断生物标志物的整合分析
Zhihan Chen,Yunfeng Dai,Fei Gao et al.
Zhihan Chen et al.
Systemic lupus erythematosus (SLE) patients are at greater risk of developing osteoporosis (OP) than the general population. This study aimed to identify crosstalk genes between SLE and OP and to validate their diagnostic accuracy as biomar...
Impact of fecal microbiota transplantation on lung function and gut microbiome in an ARDS rat model: A multi-omics analysis including 16S rRNA sequencing, metabolomics, and transcriptomics [0.03%]
粪便微生物移植对ARDS大鼠模型肺功能和肠道菌群的影响：包括16S rRNA测序、代谢组学和转录组学的多组学分析
Dongwei Zhang,Zhenqiang Zhang,Longxiong Liao et al.
Dongwei Zhang et al.
Objective: Acute respiratory distress syndrome (ARDS) is a severe pulmonary condition characterized by inflammation and lung damage, frequently resulting in poor clinical outcomes. Recent studies suggest that the gut-lung...