Evaluation of immune checkpoint inhibitor-associated hepatotoxic adverse events: A pharmacovigilance analysis based on the FAERS database [0.03%]
基于FAERS数据库的免疫检查点抑制剂相关肝毒性不良事件的评价研究
Zhihong Chen,Junwei Zhang,Lei Zhang et al.
Zhihong Chen et al.
Objective: To investigate the comprehensive landscape of hepatotoxic adverse events (AEs) associated with immune checkpoint inhibitors (ICIs), with a special focus on evaluating the potential risk of lethal hepatotoxic AE...
Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury [0.03%]
CitH3和S100A8/A9协同抑制：缓解脓毒症诱导的炎症和肺损伤的新策略
Tao Dong,Wenlu Ouyang,Xin Yu et al.
Tao Dong et al.
Objective: Sepsis is a life-threatening condition with high global morbidity and mortality. Citrullinated histone H3 (CitH3) has gained recognition as a significant biomarker for early sepsis diagnosis and management. Thi...
Chemotherapy elevates cell surface PD-L1 and MHC-I expression in apoptotic gastric cancer cells [0.03%]
化疗通过提高胃癌细胞表面的PD-L1和MHC-I表达诱导凋亡抗原的产生
You-Syuan Lou,Xu-Chen Liu,Chih-Cheng Cheng et al.
You-Syuan Lou et al.
Background: The programmed cell death-ligand 1 (PD-L1) combined positive score is used as a patient selection tool and predictive factor for anti-programmed cell death-1 (PD-1)/PD-L1 therapy in gastric cancer. However, th...
Integrative analysis of crosstalk genes and diagnostic biomarkers in lupus-associated osteoporosis [0.03%]
系统性红斑狼疮相关骨质疏松的对话基因及诊断生物标志物的整合分析
Zhihan Chen,Yunfeng Dai,Fei Gao et al.
Zhihan Chen et al.
Systemic lupus erythematosus (SLE) patients are at greater risk of developing osteoporosis (OP) than the general population. This study aimed to identify crosstalk genes between SLE and OP and to validate their diagnostic accuracy as biomar...
Impact of fecal microbiota transplantation on lung function and gut microbiome in an ARDS rat model: A multi-omics analysis including 16S rRNA sequencing, metabolomics, and transcriptomics [0.03%]
粪便微生物移植对ARDS大鼠模型肺功能和肠道菌群的影响：包括16S rRNA测序、代谢组学和转录组学的多组学分析
Dongwei Zhang,Zhenqiang Zhang,Longxiong Liao et al.
Dongwei Zhang et al.
Objective: Acute respiratory distress syndrome (ARDS) is a severe pulmonary condition characterized by inflammation and lung damage, frequently resulting in poor clinical outcomes. Recent studies suggest that the gut-lung...
Construction of a tumor immune microenvironment-related risk scoring model for prognosis of hepatocellular carcinoma [0.03%]
肝细胞癌预后相关肿瘤免疫微环境风险评分模型的建立
Xinyi Li,Zifan Qin,Haozhi Chen et al.
Xinyi Li et al.
Objective: This study aims to develop a prognostic model for HCC based on TME-related factors. Introduction: Hepatocellular carcinoma (...
Pan-cancer multi-omics analysis to identify the potential pro-oncogenic properties of GREM1 as a promising targets for cancer prognosis and therapeutics [0.03%]
泛癌多组学分析识别GREM1促致癌特性及其作为癌症预后和治疗靶点的潜力
Menglu Zhu,Hengli Zhou,Yue Zhuo et al.
Menglu Zhu et al.
We aimed to investigate the potential pro-oncogenic properties of GREM1 by Pan-cancer multi-omics analysis. Accumulating evidence has highlighted that GREM1 (Gremlin 1), serves as an inhibitor of BMP (Bone Morphogenetic Protein) family, inv...
Immune-related adverse events-pembrolizumab-induced colitis-the importance of early diagnosis and treatment: A case report and review of the literature [0.03%]
免疫相关不良事件-帕博利珠单抗诱导的结肠炎-早期诊断和治疗的重要性：病例报告及文献回顾
Marina Markovic,Danijela Niciforovic,Violeta Mladenovic et al.
Marina Markovic et al.
Immune Checkpoint Inhibitors (ICIs) are monoclonal antibodies that block inhibitory immune targets, such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), and programmed death ligand 1 (PD-L). Pembrolizum...
Causal association between type 1 diabetes and autoimmune cholestasis: A bi-directional Mendelian randomized study [0.03%]
1型糖尿病和自身免疫性胆汁淤积症之间的因果关系：双向孟德尔随机化研究
Yuanda Liu,Lanlan Chen,Wei Hao et al.
Yuanda Liu et al.
Explore the causal relationship of risk between type 1 diabetes and primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). A causal association between type 1 diabetes and autoimmune liver disease remains ambiguous. Thi...
Pharmacovigilance study of immunomodulatory drug-related adverse events using spontaneous reporting system databases [0.03%]
基于自发呈报系统的免疫调节剂相关不良事件的药物警戒研究
Satoshi Nakao,Mika Maezawa,Moe Yamashita et al.
Satoshi Nakao et al.
The aim of this study was to evaluate the country-specific reporting status profile of immunomodulatory drugs (IMiDs)-related adverse events (ImrAEs) in real-world clinical practice, using data from the Japanese Adverse Drug Event Report (J...