Protein-losing enteropathy as initial presentation of pediatric systemic lupus erythematosus: A rare case report from Vietnam and literature review [0.03%]
儿童系统性红斑狼疮蛋白丢失性肠病1例并文献复习
Cong Mai Thanh,Phuoc Nguyen Trong,Nam Nguyen Thanh
Cong Mai Thanh
Protein-losing enteropathy (PLE) is a rare but recognized manifestation of systemic lupus erythematosus (SLE). As an initial presentation of SLE, PLE is exceptionally uncommon, particularly in pediatric patients. We report the case of a 15-...
Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness [0.03%]
半乳糖凝集素-1可作为类风湿性关节炎药物疗效潜在标志物的研究
Nikola Krstić,Tatjana Jevtović Stoimenov,Sonja Stojanović et al.
Nikola Krstić et al.
The treatment approach to RA has changed over time, but the main goal of treatment has remained the same, that is, achieving disease remission. Given the lack of RA disease activity tools and biomarkers that can reliably predict RA drug eff...
Unveiling lymphocyte dynamics: Navigating postoperative immune landscapes in gastric cancer patients undergoing laparoscopic D2 gastrectomy [0.03%]
揭示淋巴细胞动态：腹腔镜D2胃切除术治疗胃癌患者的术后免疫景观导航
Chun Gao,Li Zhu,Yi Xin Tong et al.
Chun Gao et al.
Introduction: Patients with locally advanced gastric cancer often face postoperative complications and insufficient short-term outcomes. Understanding the changes in peripheral lymphocyte subsets following laparoscopic D2...
Kaempferide and Norbergenin avert aluminium chloride-induced amyloid β accumulation and neurocognitive shutdown via oxidative and apoptotic mechanisms [0.03%]
kaempferide和norbergenin通过氧化和凋亡机制防止氯化铝诱导的amyloid β积累和神经认知停滞
Swathi Nalla,Suhasin Ganta,Sarad Pawar Naik Bukke et al.
Swathi Nalla et al.
Objective: To investigate the involvement of oxidative and apoptotic mechanisms in the possible neuroprotective effect of Kaempferide (KPD) and Norbergenin (NRG) against AlCl3-induced cognitive shutdown in rats. ...
A new heterozygous TYK2 gene mutation: Case report and review of the literature [0.03%]
TYK2基因新杂合突变病例报告和文献综述
Lei Xie,Xinyue Hu,Hejing Wang et al.
Lei Xie et al.
Tyrosine kinase 2 (TYK2) deficiency is a rare primary immunodeficiency disease (PID). Patients carry TYK2 gene mutations and suffer from recurrent infections by intracellular pathogens, including mycobacteria. Delayed diagnosis often hinder...
Blocking leukotriene receptors improve experimentally induced gastric ulcers in rats by inhibiting inflammation and apoptosis [0.03%]
白三烯受体阻断剂通过抑制炎症和细胞凋亡改善实验性胃溃疡
Hanan M Hassan,Alaa Bagalagel,Reem Diri et al.
Hanan M Hassan et al.
To investigate whether obstructing the cysteinyl leukotriene receptor-1 (CYSLTR1) with zafirlukast diminishes experimentally induced gastric ulcer (GU) in rats by modulating inflammation and apoptosis. Gastric ulcers affect approximately 10...
High expression of CCL3/CCL4/CCL5/CCR5 promotes exhausted CD8+ T cells terminal differentiation and is associated with poor prognosis in pediatric B-ALL patients [0.03%]
CCL3/CCL4/CCL5/CCR5高表达促进儿童B-急淋患者耗竭性CD8+T细胞向终末分化并与预后不良相关
Jiamian Zheng,Yupei Zhang,Xueting Peng et al.
Jiamian Zheng et al.
This study aims to identify differentially upregulated ligand-receptor interactions between B-ALL cells and exhausted CD8+ T cells and to develop a multivariate Cox regression model for predicting the overall survival of pediatric B-ALL pat...
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice [0.03%]
cucurbitacin B通过抑制janus激酶/信号转导子和转录激活子通路而抑制th17细胞分化并减轻小鼠胶原诱导的关节炎
Shu-Ping Kung,Hira Umbreen,Jou-Hsuan Wang et al.
Shu-Ping Kung et al.
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited treatment options and associated side effects or resistance. This study aims to investigate the therapeutic potential of the natural compou...
MicroRNA-21-5p regulates autophagy and apoptosis via the activation of the PI3K/AKT/mTOR signaling pathway and reducing H2O2-induced damage in primary AEC-II [0.03%]
miR-21-5p通过激活PI3K/Akt/mTOR信号通路和减少H2O2诱导的损伤来调节自噬和凋亡
Xinxin Liu,Qiuyu Dai,Jie Zheng et al.
Xinxin Liu et al.
Objective: We examined whether miR-21-5p activates the PI3K/AKT/mTOR signaling pathway, thereby inhibiting autophagy and apoptosis induced by H2O2 in AEC II cells. ...
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7 [0.03%]
GNF-5837通过上调谷胱甘肽过氧化物酶7缓解椎间盘老化
Yangkai Xu,Rongsheng Chen,Yan Zhuang et al.
Yangkai Xu et al.
Objective: The aim of this study was to investigate the role of glutathione peroxidase 7 (GPX7) in mitigating oxidative stress-induced cellular ageing and its contribution to intervertebral disc degeneration (IVDD). ...