Agmatine suppresses the imidazoline I2 receptor/ribosomal S6 kinase 2/NF-κB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury [0.03%]
_agmatine通过抑制AGMATINE对IMIDAZOLINE I₂受体/RSK2/NF-κB信号通路的调控作用调节巨噬细胞极化改善内毒素致急性肺损伤的作用及机制研究
Linguo Bai,Kun Yu,Qiuyu Dai et al.
Linguo Bai et al.
Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury characterized by damage to alveolar epithelial cells and pulmonary capillary endothelial cells. Compared with ARDS caused by other causes, the subtypes ...
Impact of hepatitis C virus on oral health: Clinical lesions, immunopathology, and dental management: A narrative review [0.03%]
丙型肝炎病毒感染对口腔健康的影响：临床表现、免疫病理和牙科治疗：综述文章
Mario Alberto Alarcón-Sánchez,Valeria Henao-Díaz,Lilibeth-Stephania Escoto-Vasquez et al.
Mario Alberto Alarcón-Sánchez et al.
Hepatitis C virus (HCV) infection is a major global public health problem. Although it has traditionally been linked to liver damage, several studies have demonstrated its extrahepatic impact, specifically in the oral cavity. Oral manifesta...
Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats [0.03%]
重复给予大麻二酚可减少大鼠脾淋巴细胞亚群数量
Tara H Turkki,Maciej M Jankowski,Wojciech Glac et al.
Tara H Turkki et al.
Objective: Cannabidiol (CBD) administration (5 mg/kg) in healthy rats has been shown to significantly decrease lymphocyte subset numbers in peripheral blood without involvement of natural killer cells. The aim was to eval...
Oral keratinocyte-mediated inflammation and epithelial disruption: A narrative review on IRF6 signaling and oral carcinogenic risk [0.03%]
口腔角质细胞介导的炎症和上皮损伤：关于IRF6信号传导和口腔致癌风险的叙述性综述
Yuliana Andrea Osorio-Osorno,Monica Tatiana Parada-Sanchez
Yuliana Andrea Osorio-Osorno
The oral epithelium is a dynamic interface between host and environment, where keratinocytes not only serve as structural components but also actively modulate immune responses. Emerging research identifies IRF6 as a pivotal regulator of ep...
Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in chronic kidney disorder induced vascular calcification [0.03%]
靶向螯合治疗通过血管细胞降低NLRP3表达，并在慢性肾脏疾病诱导的血管钙化中发挥抗衰老作用
Shivani Arora,Gregory Halsey,Fatema Tuj Zohora et al.
Shivani Arora et al.
Objective: This study aimed to evaluate whether EDTA-based targeted chelation therapy can act as senomorphic in chronic kidney disease (CKD)-induced vascular calcification. ...
Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice [0.03%]
asiatic酸通过抑制NF-κB信号通路改善小鼠急性及慢性的结肠炎作用机制研究
Seona Park,Hyun Jung Lee,Seong-Joon Koh et al.
Seona Park et al.
Objective: This study aimed to elucidate the anti-inflammatory mechanisms of asiatic acid (AA) by focusing on its modulation of the nuclear factor-κB (NF-κB) signaling pathway and to evaluate its therapeutic effects in ...
Pre-activation status impacts regenerative potential of oligodendrocyte progenitors in an LPS-exposed animal model [0.03%]
预先激活状态影响内毒素暴露动物模型中少突胶质前体细胞的再生潜能
Farzaneh Rezaei Yazdi,Parichehr Pasbakhsh,Hoda Akbari et al.
Farzaneh Rezaei Yazdi et al.
Introduction & aims: Optimal neural activity in the central nervous system relies on the myelin sheath formed by oligodendrocytes. During demyelination, changes in the microenvironment can activate oligodendrocyte precurs...
Translation element EIF4A1 is a potential divergent immune biomarker between colon cancer and rectal cancer [0.03%]
翻译元件EIF4A1是结肠癌和直肠癌之间潜在的免疫差异生物标志物
Zhenpeng Zhu,Peng Wang,Chenyang Hou et al.
Zhenpeng Zhu et al.
Objective: Given the global high incidence of colorectal cancer (CRC) and the need for subtype-specific molecular targets, this study aims to investigate the role and therapeutic potential of EIF4A1 in colon and rectal ca...
Intravenous immunoglobulins in Henoch-Schönlein purpura with severe gastrointestinal involvement. Case report and review of the literature [0.03%]
重症胃肠受累的亨诺赫-许恩旦综合征的静脉用免疫球蛋白治疗：1例报告及文献复习
Marco Pappalardo,Lucrezia Passadore,Marco Manfredi et al.
Marco Pappalardo et al.
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children. It often follows a viral infection. Although it is a self-limiting disease, various acute, and chronic complications can occur. We describe a case of a 6-ye...
Role of β and α1-adrenoceptors in pancreatic regulation of glucose homeostasis, apoptosis, and fibrosis in dexamethasone-treated rats: A new insight into β-arrestin2 crosstalk with cAMP, PKA-ERK1/2-CREB, and PKB-FOXO1 signaling pathways [0.03%]
β和α1肾上腺素受体在地塞米松诱导的大鼠胰岛调节葡萄糖稳态、细胞凋亡及纤维化中的作用：一个新的β-arrestin2信号交叉途径与cAMP，PKA-ERK1/2-CREB以及PKB-FOXO1通路的洞察
Nehal S Wahba,Ahmed Abdelfattah-Hassan,Dalia A Hemead et al.
Nehal S Wahba et al.
Objective: The current study aimed to investigate the role of β and α1-adrenoceptors in pancreatic regulation of glucose homeostasis, apoptosis, and fibrosis in a rat model of dexamethasone-induced insulin resistance. ...