Eva Bártová
Eva Bártová
Gene therapy is a focus of interest in both human and veterinary medicine, especially in recent years due to the potential applications of CRISPR/Cas9 technology. Another relatively new approach is that of epigenetic therapy, which involves...
Michael K Skinner
Michael K Skinner
Exposure to air pollution is associated with DNA methylation changes in sperm [0.03%]
空气污染与精子DNA甲基化改变有关
Rose Schrott,Jason I Feinberg,Craig J Newschaffer et al.
Rose Schrott et al.
Exposure to air pollutants has been associated with adverse health outcomes in adults and children who were prenatally exposed. In addition to reducing exposure to air pollutants, it is important to identify their biologic targets in order ...
Marta Gallazzi,Marta Pizzolante,Elia Mario Biganzoli et al.
Marta Gallazzi et al.
Epigenetics, the study of heritable changes in gene expression without altering the DNA sequence, has gained significant attention due to its implications for gene regulation and chromatin stability. Epigenetic mechanisms play a fundamental...
Characterization of genomic regions escaping epigenetic reprogramming in sheep [0.03%]
绵羊基因组中逃逸上代表观遗传修饰的区域的特征分析
Camila U Braz,Matilde Maria Passamonti,Hasan Khatib
Camila U Braz
The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA...
Symposium summary: epigenetic inheritance-impact for biology and society 23-25 August 2023, Zürich, Switzerland [0.03%]
研讨会总结：表观遗传继承——对生物和社会影响，2023年8月23-25日，瑞士苏黎世
Leonard C Steg,Ellen Jaspers,Anar Alshanbayeva et al.
Leonard C Steg et al.
The possibility that acquired traits can be transmitted across generations has been the subject of intense research in the past decades. This biological process is of major interest to many scientists and has profound implications for biolo...
Effect of high temperatures on sex ratio and differential expression analysis (RNA-seq) of sex-determining genes in Oreochromis niloticus from different river basins in Benin [0.03%]
高温对来自贝宁不同河流域的尼罗 tilapia(Oreochromis niloticus)性别比例及性决定基因差异表达分析(RNA-seq)的影响
Mohammed Nambyl A Fagbémi,Renaud Nivelle,Marc Muller et al.
Mohammed Nambyl A Fagbémi et al.
The high temperature sex reversal process leading to functional phenotypic masculinization during development has been widely described in Nile tilapia (Oreochromis n iloticus) under laboratory or aquaculture conditions and in the wild. In ...
Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity [0.03%]
多重代际不同毒物暴露引起表观遗传的跨代增强病理和肥胖继承
Eric E Nilsson,Margaux McBirney,Sarah De Santos et al.
Eric E Nilsson et al.
Three successive multiple generations of rats were exposed to different toxicants and then bred to the transgenerational F5 generation to assess the impacts of multiple generation different exposures. The current study examines the actions ...
Identifying unique exposure-specific transgenerational differentially DNA methylated region epimutations in the genome using hybrid deep learning prediction models [0.03%]
使用混合深度学习预测模型在基因组中识别独特的暴露特异性跨代差异DNA甲基化区域表观突变
Pegah Mavaie,Lawrence Holder,Michael Skinner
Pegah Mavaie
Exposure to environmental toxicants can lead to epimutations in the genome and an increase in differential DNA methylated regions (DMRs) that have been linked to increased susceptibility to various diseases. However, the unique effect of pa...
Inheritance of environment-induced phenotypic changes through epigenetic mechanisms [0.03%]
通过表观机制传递环境诱导的性状变化
Yukiko Tando,Yasuhisa Matsui
Yukiko Tando
Growing evidence suggests that epigenetic changes through various parental environmental factors alter the phenotypes of descendants in various organisms. Environmental factors, including exposure to chemicals, stress and abnormal nutrition...