Prenatal per- and polyfluoroalkyl substance exposures and DNA methylation among newborns in the Environmental influences on Child Health Outcomes program [0.03%]
基于环境对儿童健康影响的项目中孕妇的多氟烷基物质暴露与新生儿DNA甲基化状况的关系研究
Rose Schrott,Christine Ladd-Acosta,Vasantha Padmanabhan et al.
Rose Schrott et al.
Gestation is a vulnerable window when exposure to per- and polyfluoroalkyl substances (PFAS) may impact child development and health. Epigenetic modification, including DNA methylation (DNAm), may be one mechanism linking prenatal PFAS expo...
Interaction of mercury exposure and DNA methylation with sustained attention in children in a novel analysis of epigenetic susceptibility [0.03%]
甲基汞暴露对儿童持续注意力的影响及DNA甲基化修饰的敏感性分析
Jessa V Ehlinger,Jaclyn M Goodrich,Dana C Dolinoy et al.
Jessa V Ehlinger et al.
The etiology of attention-deficit/hyperactivity disorder (ADHD) remains poorly understood, despite it being one of the most common neurodevelopmental disorders worldwide. Past research suggests methylmercury exposure and DNA methylation (DN...
Silencing TET1 expression alters the epigenomic landscape and amplifies transcriptomic responses to allergen in airway epithelial cells [0.03%]
TET1表达沉默改变表观基因组景观并放大气道上皮细胞过敏原转录反应
Anthony P Brown,Sreeja Parameswaran,Lucy Cai et al.
Anthony P Brown et al.
Previous studies have demonstrated that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a protective role against house dust mite (HDM)-induced allergic airway inflammation. TET1 transcriptionally responded to HDM extract...
Non-genotoxic carcinogens (TPA and mezerein) activate tumourous transformation through miR let-7-mediated Hmga2 expression in Bhas42 cells [0.03%]
非致畸性致癌物(TPA和没药素)通过miR let-7介导的Hmga2表达激活Bhas42细胞恶性转化
Moon Yi Ko,Euijun Min,Minjeong Kim et al.
Moon Yi Ko et al.
A Bhas42 cell transformation assay is a method used to detect the tumour-promoting activities of chemicals. However, the mechanisms underlying tumour transformations mediated by non-genotoxic carcinogens (NGCs) are poorly understood. This s...
Exosomal miR-34b-3p upregulated in response to hypoxia preconditioning modulates circadian rhythms through the targeting of Clock [0.03%]
响应于低氧预处理上调的囊泡miR-34b-3p通过靶向Clock来调节昼夜节律
Yiquan Yan,Fengzhou Liu,Tongmei Zhang et al.
Yiquan Yan et al.
The relationship between circadian rhythm disorders and the development of various diseases appears to be significant, with limited current interventions available. Research literature suggests that hypoxia may influence the expression of c...
Transgenerational inheritance of hepatic steatosis in mice: sperm methylome is largely reprogrammed and inherited but does not globally influence liver transcriptome [0.03%]
小鼠肝脂肪变性的跨代遗传：精子甲基化组被大量重新编程并遗传，但不会全局性地影响肝脏转录组
Sílvia Ribó,Marta Ramon-Krauel,Josep M Marimon-Escude et al.
Sílvia Ribó et al.
Nutritional challenges and obesity can contribute to the transmission of metabolic diseases through epigenetic mechanisms. Among them, DNA methylation stands out as a potential carrier of information because germline cytosine methylation re...
Michael K Skinner
Michael K Skinner
Longitudinal leucocyte DNA methylation changes in Mesoamerican nephropathy [0.03%]
中美洲肾病的纵向粒系细胞DNA甲基化改变
Amin Oomatia,Olga Chervova,Ali M Al-Rashed et al.
Amin Oomatia et al.
Mesoamerican nephropathy (MeN) is a leading cause of morbidity and mortality in Central America, yet its aetiology remains unclear. Environmental exposures including heat stress, pesticides, and heavy metals have all been suggested as possi...
A systematic review of associations between the environment, DNA methylation, and cognition [0.03%]
环境与DNA甲基化和认知的系统评价
Sophie Glover,Jacob Illyuk,Claire Hill et al.
Sophie Glover et al.
The increasing prevalence of neurodegenerative diseases poses a significant public health challenge, prompting a growing focus on addressing modifiable risk factors of disease (e.g. physical inactivity, mental illness, and air pollution). T...
Airborne fine particulate matter exposure induces transcriptomic alterations resembling asthmatic signatures: insights from integrated omics analysis [0.03%]
空气动力学直径小于2.5微米的细颗粒物暴露引起的转录组改变类似于哮喘特征：整合组学分析提供新见解
Daniel González,Alexis Infante,Liliana López et al.
Daniel González et al.
Fine particulate matter (PM2.5), an atmospheric pollutant that settles deep in the respiratory tract, is highly harmful to human health. Despite its well-known impact on lung function and its ability to exacerbate asthma, the molecular basi...