An exploratory analysis of miRNAs measured in placental tissue and their associations with prenatal exposure to household air pollution [0.03%]
基于胎盘组织中测量的miRNAs对其暴露于家用空气污染的探索性分析
Abigail Gaylord,Mohammed Nuhu Mujtaba,Michelle Li et al.
Abigail Gaylord et al.
Household air pollution (HAP) has been associated with adverse pregnancy and birth outcomes, but the underlying mechanisms remain unclear. Pollutants can cross the placenta, potentially causing dysregulation of the crucial organ. Placental ...
Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood [0.03%]
孕期金属混合物暴露对脐带血DNA甲基化细胞类型组成的影响
Sandra India-Aldana,Hachem Saddiki,Luigi Annicchiarico et al.
Sandra India-Aldana et al.
Metal(loid) exposure can exert immunotoxic effects, including changes in white blood cell proportions. The impact from metal exposure mixtures during pregnancy has not been examined in relation to cell-type composition at birth. Our aim was...
Triphenyl phosphate induces coordinated DNA methylation and gene expression changes in aquatic embryonic cells [0.03%]
三苯基磷酸盐诱导水生胚胎细胞中协同的DNA甲基化和基因表达变化
Logan S Germain,Benjamin P Ott,Charles C T Hindmarch et al.
Logan S Germain et al.
Triphenyl phosphate (TPHP) is a high-production-volume flame retardant and plasticizer that is widely detected in the environment and in biomonitoring studies. TPHP exposure has been linked to endocrine disruption, metabolic disruption, gen...
Michael K Skinner
Michael K Skinner
Preeclampsia and environmental epigenomics: the emerging role of air pollution, gut microbiome, and maternal exposures in disease programming [0.03%]
子痫前期与环境表观基因组学：空气污染、肠道菌群和母体暴露在疾病编程中的作用不容忽视
Geethika Yelleti,Nihaal Maripini,Varashree Bolar Suryakanth
Geethika Yelleti
Preeclampsia (PE) remains a major contributor of maternal and fetal morbidity and mortality worldwide, affecting 2%-8% of pregnancies. While genetic predisposition, placental dysfunction, and angiogenic imbalance remain central to PE pathop...
Sex-dependent biobehavioural responses to transgenerational maternal stress: evidence of stress resilience and vulnerability in the F3 generation [0.03%]
跨代母体压力的性别差异型生物行为反应：F3代压力抵抗与脆弱性的证据
Jamshid Faraji,Nicola Schatz,Stephanie King et al.
Jamshid Faraji et al.
Maternal prenatal stress can determine stress resilience and vulnerability of future generations. However, the extent to which the biological sex of the descendants determines the response to ancestral stress is not fully understood. In thi...
Generational stability of environmentally induced epigenetic transgenerational inheritance of adult-onset disease over ten mammalian generations [0.03%]
表观遗传跨世代效应在十代哺乳动物中的稳定传递导致成年期发病
Alexandra A Korolenko,Eric E Nilsson,Sarah De Santos et al.
Alexandra A Korolenko et al.
In traditional models of Drosophila flies and Caenorhabditis elegans worms, epigenetic transgenerational inheritance has persisted for hundreds of generations. Mammalian studies, however, have primarily investigated up to three or four gene...
Parental benzo[a]pyrene exposure impacts histone modifications in osteoblast subpopulations [0.03%]
父母苯并[a]芘暴露影响骨细胞亚群组蛋白修饰
Alexis S Trujillo,Remi O Labeille,Rijith Jayarajan et al.
Alexis S Trujillo et al.
Environmental stressors, such as benzo[a]pyrene (BaP), have been repeatedly associated with developmental bone defects in offspring after parental exposures. Chemical modifications along the histone 3 protein (H3) and histone 4 protein (H4)...
DNA methylation patterns linked to salinity and geography in the American eel (Anguilla rostrata) [0.03%]
与美洲鳗鱼(Anguilla rostrata)盐度和地理位置相关的DNA甲基化模式
Gabriela Ulmo Díaz,Céline Audet,Eric Normandeau et al.
Gabriela Ulmo Díaz et al.
The panmictic American eel (Anguilla rostrata) displays a wide range of intraspecific phenotypic variation as well as geographical sex bias and differential recruitment. By definition, panmictic species lack genetic structure, thus local ad...
Early-life exposure to secondhand smoke and polycyclic aromatic hydrocarbons: associations with epigenetic aging among children [0.03%]
儿童时期接触二手烟和多环芳烃与表观遗传衰老的关系
Sneha S Patil,Anne K Bozack,Ajay Pillarisetti et al.
Sneha S Patil et al.
Epigenetic clocks are valuable tools for assessing biological age. Exposure to secondhand smoke (SHS) and polycyclic aromatic hydrocarbons (PAHs) has been linked with epigenetic age deviation (EAD) in adults. However, associations in childr...