A systematic review investigating the relationship between green and blue spaces and depression in older adults via DNA methylation [0.03%]
通过DNA甲基化研究绿地和蓝空间与老年人抑郁关系的系统评价
Jacob Illyuk,Sophie Glover,Shea A Walsh et al.
Jacob Illyuk et al.
Depression in older adults has been associated with negative health outcomes, such as dementia. Previous research has demonstrated that green and blue spaces, defined as areas of vegetation or bodies of water respectively, are beneficial to...
Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges [0.03%]
环境暴露与常见慢性病的表观遗传改变：启示和挑战
Cathrine Hoyo,Chantel L Martin,Terrence Allen et al.
Cathrine Hoyo et al.
Exposure to environmental factors including contaminants and social conditions is implicated in a substantial proportion of common non-communicable diseases, and data from model systems repeatedly demonstrate that the process from environme...
Epigenetic mechanisms linking hexavalent chromium exposure to pancreatic cancer risk: a systematic review [0.03%]
六价铬暴露与胰腺癌发病风险相关的表观遗传机制：系统性综述
Kai Hayashi,Yicong Huang,Kenneth R Muir et al.
Kai Hayashi et al.
Pancreatic cancer remains one of the most lethal malignancies, largely due to late diagnosis and limited treatment options. Hexavalent chromium (Cr(VI)) is a well-established environmental and occupational carcinogen, and emerging epidemiol...
Epigenetic mechanisms linking the perinatal environment, the placenta, and maternal and child health outcomes: evidence for sexual dimorphism [0.03%]
胎盘表观遗传机制与母体及儿童健康结局的关联：性别差异证据
Hadley J Hartwell,Rebecca C Fry
Hadley J Hartwell
Exposure to adverse environments early in life can shape health trajectories across the lifespan. A key mechanism by which this life-long reprogramming occurs is via epigenetic modifications, including altered DNA methylation (DNAm), histon...
m6A RNA methylation regulatory gene expression in response to ethanol and acetaldehyde exposure and withdrawal [0.03%]
乙醇和乙醛暴露及停药过程中的m6A RNA甲基化调控基因表达反应性研究
Ji Sun Koo,Qiansheng Zhan,Huiping Zhang
Ji Sun Koo
6-methyladenosine (m6A) RNA methylation, regulated by writer, eraser, and reader proteins, modulates mRNA stability, splicing, and translation, thereby influencing key cellular processes. Environmental stressors, such as alcohol, may disrup...
Transgenerational reproductive risks of BPA: epigenetic mechanisms and biomarker applications. A critical review [0.03%]
双酚A的跨代生殖风险：表观遗传机制及生物标志物应用的批判性综述
Okon Michael Ben,Olorunnisola Sinbad Olubukola,Ifie Josiah Eseoghene et al.
Okon Michael Ben et al.
Bisphenol A (BPA), which is a common ingredient of plastics and epoxy resins, is among the most commonly found endocrine-disrupting chemicals in the human environment. Chronic human exposure has raised concerns over its effects on reproduct...
Seasonal timing in a changing world: the epigenetic link between environment and reproduction across taxa [0.03%]
变化世界中的季节性时机：环境与繁殖之间的表观遗传联系穿越分类单元分析
Heidi M Viitaniemi,Tyler J Stevensson,Arild Husby
Heidi M Viitaniemi
All plants and animals must time their annual reproduction to seasonal variation in resources to optimize reproductive fitness. Environmental factors such as photoperiod and temperature are well known to influence seasonal timing of reprodu...
Shyleen Frost,Kathy Pham,Erica C Heinrich
Shyleen Frost
High altitude presents a significant environmental stressor in the form of hypobaric hypoxia. The body responds to this condition with various acclimatization mechanisms, yet the role of epigenetic modifications, particularly DNA methylatio...
DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities [0.03%]
DNA甲基化作为产前暴露生物标志物的当前挑战和机遇
Rachel B Walkup,Matthew A Nangle,Phillip E Bergmann et al.
Rachel B Walkup et al.
The prenatal environment contributes to the risk for congenital conditions, including birth defects, developmental disorders, and diseases that manifest in later life. However, our current understanding of prenatal exposures and their impac...
Diazinon may increase the risk of acute lymphoblastic leukemia by inducing MGMT promoter methylation [0.03%]
敌敌畏通过诱导MGMT启动子甲基化可能增加急性淋巴细胞白血病的发病风险
Arash Rafeeinia,Mehrnaz Karimi Darabi,Reza Sadeghi et al.
Arash Rafeeinia et al.
Background and objective: Acute lymphoblastic leukemia (ALL) is the most frequent childhood malignancy, which is impacted by genetic, epigenetic, and environmental variables. Aberrant methylation of genes, such as O6-meth...