Parental benzo[a]pyrene exposure impacts histone modifications in osteoblast subpopulations [0.03%]
父母苯并[a]芘暴露影响骨细胞亚群组蛋白修饰
Alexis S Trujillo,Remi O Labeille,Rijith Jayarajan et al.
Alexis S Trujillo et al.
Environmental stressors, such as benzo[a]pyrene (BaP), have been repeatedly associated with developmental bone defects in offspring after parental exposures. Chemical modifications along the histone 3 protein (H3) and histone 4 protein (H4)...
DNA methylation patterns linked to salinity and geography in the American eel (Anguilla rostrata) [0.03%]
与美洲鳗鱼(Anguilla rostrata)盐度和地理位置相关的DNA甲基化模式
Gabriela Ulmo Díaz,Céline Audet,Eric Normandeau et al.
Gabriela Ulmo Díaz et al.
The panmictic American eel (Anguilla rostrata) displays a wide range of intraspecific phenotypic variation as well as geographical sex bias and differential recruitment. By definition, panmictic species lack genetic structure, thus local ad...
Early-life exposure to secondhand smoke and polycyclic aromatic hydrocarbons: associations with epigenetic aging among children [0.03%]
儿童时期接触二手烟和多环芳烃与表观遗传衰老的关系
Sneha S Patil,Anne K Bozack,Ajay Pillarisetti et al.
Sneha S Patil et al.
Epigenetic clocks are valuable tools for assessing biological age. Exposure to secondhand smoke (SHS) and polycyclic aromatic hydrocarbons (PAHs) has been linked with epigenetic age deviation (EAD) in adults. However, associations in childr...
Redundancy, noise, and plasticity: repetitive DNA as an epigenetic intelligence backbone of inflammatory regulation [0.03%]
冗余、噪声与可塑性：重复DNA为炎症调控表观遗传机制的智能骨架
Valentina Bollati,Elia Biganzoli
Valentina Bollati
Background: Repetitive DNA elements such as LINE1 have been proposed to support a redundant distributed, adaptive layer of gene regulation, contributing to "Epigenetic Intelligence" (EI). However, empirical evidence for t...
A cost-effective method for combining the power of genetic and epigenetic selection in animal production [0.03%]
一种在动物育种中结合基因和表观基因选择力量的有效方法
Núria Sánchez-Baizán,Marine Herlin,Adrián Millán et al.
Núria Sánchez-Baizán et al.
Traditional breeding programs have largely focused on genetics, often overlooking environmental and epigenetic influences on phenotypic variability. Current methods for developing epigenetic biomarkers (EBs) with machine learning (ML) algor...
Randy L Jirtle
Randy L Jirtle
Genomic imprinting is a phenomenon in which one parental allele is silenced epigenetically. My research has focused on the role of epigenetics in human health and disease since 1995 when we identified the first tumor suppressor gene that is...
Thomas Kenney,Tony Montina,Gerlinde A S Metz
Thomas Kenney
Whole methylomes reveal high-altitude-associated methylation at hypoxia and pigmentation genes in South American Indigenous populations [0.03%]
甲基化组揭示了南美原住民中与高原适应相关的低氧和色素沉着基因的甲基化现象
Yemko Pryor,Nicola Rambaldi Migliore,Daniel Rivas Alava et al.
Yemko Pryor et al.
High-altitude adaptation in Andean populations has traditionally been studied through the lens of genetic variation, with limited exploration of epigenetic mechanisms such as DNA methylation. Here, we present the first whole-methylome data ...
Epigenetic modifications and transgenerational inheritance in women victims of violence (EWVV) [0.03%]
暴力受害女性的表观遗传修饰及跨代传递(EWVV)
Donato Gemmati,Matteo Villanova,Fabio Scarpellini et al.
Donato Gemmati et al.
Female survivors of physical or psychological violence, including sexual violence, report significant long-term consequences defined as post-traumatic stress disorder (PTSD). Among these, depression, affective difficulties, anomalous behavi...
Association between maternal perceived stress during pregnancy and offspring DNA methylation changes in HPA axis genes at birth in the ECHO Consortium [0.03%]
孕产妇孕期压力感知与表观遗传学因素在埃奇奥联盟后代出生时下丘脑-垂体-肾上腺轴基因DNA甲基化改变之间的关系研究
Krystin Jones,Bianca P Acevedo,Lyndsay A Avalos et al.
Krystin Jones et al.
Evidence has linked maternal exposure to stress during pregnancy with poor offspring health and neurodevelopmental outcomes. However, the precise mechanism by which this may occur has not been fully elucidated. In this study, we examined wh...