Cornelius Roemer,Daniel J Sheward,Ryan Hisner et al.
Cornelius Roemer et al.
Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages, and identify the most prevalen...
Mpox virus infection and drug treatment modelled in human skin organoids [0.03%]
人皮肤类器官模拟猴痘病毒感染和药物治疗模型
Pengfei Li,Spyridon T Pachis,Guige Xu et al.
Pengfei Li et al.
Mpox virus (MPXV) primarily infects human skin to cause lesions. Currently, robust models that recapitulate skin infection by MPXV are lacking. Here we demonstrate that human induced pluripotent stem cell-derived skin organoids are suscepti...
Florencia Díaz-Viraqué,María Laura Chiribao,María Gabriela Libisch et al.
Florencia Díaz-Viraqué et al.
Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease. Genomes of these parasites comprise core regions and species-specific disrup...
Adipocyte lipolysis protects mice against Trypanosoma brucei infection [0.03%]
脂肪细胞溶脂作用可保护小鼠免受布氏锥虫感染
Henrique Machado,Peter Hofer,Rudolf Zechner et al.
Henrique Machado et al.
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and inducing weight loss. Here we investigated the molecular mechanisms responsible for adipose mass loss and its impact on disease pathology. We found that lipoly...
Publisher Correction: A genome catalogue of lake bacterial diversity and its drivers at continental scale [0.03%]
订正：大陆规模下湖泊细菌多样性的基因组目录及其驱动因素
Rebecca E Garner,Susanne A Kraemer,Vera E Onana et al.
Rebecca E Garner et al.
Published Erratum
Nature microbiology. 2024 May;9(5):1395. DOI:10.1038/s41564-023-01515-7 2024
Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis [0.03%]
卡介苗静脉接种可保护感染了猴免疫缺陷病毒的猕猴免受结核分枝杆菌的侵袭
Erica C Larson,Amy L Ellis-Connell,Mark A Rodgers et al.
Erica C Larson et al.
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette-Guérin (BCG) delivery is the only licensed vaccine against ...
Antiviral responses are shaped by heterogeneity in viral replication dynamics [0.03%]
抗病毒反应受到病毒感染异质性的影响
Lucas J M Bruurs,Micha Müller,Jelle G Schipper et al.
Lucas J M Bruurs et al.
Antiviral signalling, which can be activated in host cells upon virus infection, restricts virus replication and communicates infection status to neighbouring cells. The antiviral response is heterogeneous, both quantitatively (efficiency o...
Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus [0.03%]
细菌BDLLOVIBIRIO BACTERIOPHORUS 中一种以非传统方式结合DNA的组蛋白成为染色体的主要组成部分
Antoine Hocher,Shawn P Laursen,Paul Radford et al.
Antoine Hocher et al.
Histone proteins bind DNA and organize the genomes of eukaryotes and most archaea, whereas bacteria rely on different nucleoid-associated proteins. Homology searches have detected putative histone-fold domains in a few bacteria, but whether...
Systematic analyses identify modes of action of ten clinically relevant biocides and antibiotic antagonism in Acinetobacter baumannii [0.03%]
系统分析鉴定了10种临床相关消毒剂和抗生素对阿氏伯克霍尔德菌的作用模式及相互作用关系
Liping Li,Francesca L Short,Karl A Hassan et al.
Liping Li et al.
Concerns exist that widespread use of antiseptic or disinfectant biocides could contribute to the emergence and spread of multidrug-resistant bacteria. To investigate this, we performed transposon-directed insertion-site sequencing (TraDIS)...