Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota [0.03%]
泛醌输送丝状物可提升革兰氏阳性芽胞杆菌纲的生物能学容量
Ashleigh Kropp,Kazem Asadollahi,Jamie A Stapleton et al.
Ashleigh Kropp et al.
Cellular respiration depends on transferring electrons to hydrophobic quinones in membrane bilayers, meaning bioenergetic capacity is constrained by available membrane surface area. While Gram-negative bacteria expand this capacity through ...
Global microbial DNA signatures of temperature and nutrient limitation across ecosystems [0.03%]
全球生态系统中微生物DNA特征的温度和营养限制签名
Tomer Antman,Ohad Lewin-Epstein,Tamir Yerushalmi et al.
Tomer Antman et al.
Microbial genomes continuously adapt to environmental conditions, but identifying universal signatures of adaptation remains challenging. Here we show that environmental temperature can be accurately predicted across ecosystems from DNA com...
Genomic catalogue of giant viruses reveals expanded diversity and functional potential [0.03%]
基因组目录中的巨病毒揭示了扩展的多样性和功能潜力
Yumary M Vasquez,Tiago Nardi,Gbocho Masato Terasaki et al.
Yumary M Vasquez et al.
Nucleocytoplasmic large DNA and Mirusviricota viruses exhibit taxonomic richness which continually expands due to metagenomic sequencing. Here we curate a database of giant virus metagenome-assembled genomes (GVMAGs V2), comprising 8,508 sp...
Antisense transcription reveals disease-associated adaptations in the human gut microbiome [0.03%]
反向转录揭示人类肠道微生物组中的疾病相关适应性
Marie-Madlen Pust,Ahmed M T Mohamed,Martin Stražar et al.
Marie-Madlen Pust et al.
The gut microbiome is a dynamic ecosystem in which microorganisms constantly adjust their transcriptional programmes. Here we developed metastrand, a framework that integrates strand-aware metatranscriptomics and metagenomics to quantify mR...
Combination therapy with broadly neutralizing antibodies, antiretroviral therapy and CCR5 blockade limits viral reservoir seeding in infant macaque model of HIV [0.03%]
广谱中和性抗体、抗逆转录病毒疗法及CCR5阻断联合治疗限制了HIV感染猕猴婴儿模型中的病毒储存库的生成
Jonah B Sacha,Tracy Ordonez,Shilpi Pandey et al.
Jonah B Sacha et al.
Lack of access to antiretroviral therapy (ART) leads to the transmission of human immunodeficiency virus in ~120,000 children annually, emphasizing the need for new strategies to prevent lifelong infection. Here in an infant rhesus macaque ...
Combination therapy with broadly neutralizing antibodies, antiretroviral therapy and CCR5 blockade limits viral reservoir seeding in infant macaque model of HIV [0.03%]
广谱中和抗体、抗逆转录病毒疗法和CCR5阻断联合治疗限制了恒河猴婴儿HIV模型中的病毒库播种
Jonah B Sacha,Tracy Ordonez,Shilpi Pandey et al.
Jonah B Sacha et al.
Lack of access to antiretroviral therapy (ART) leads to the transmission of human immunodeficiency virus in ~120,000 children annually, emphasizing the need for new strategies to prevent lifelong infection. Here in an infant rhesus macaque ...
Silvia Bulgheresi
Silvia Bulgheresi
Sergio Gutiérrez,Edmar R Oliveira-Filho
Sergio Gutiérrez
Antiviral defence is a conserved function of diverse bacterial DNA glycosylases [0.03%]
抗病毒防御是细菌DNA糖基化酶的保守功能
Landon J Getz,Amy L Qian,Y Vivian Liu et al.
Landon J Getz et al.
Bacteria are frequently attacked by viruses, known as phages, and rely on diverse defence systems to survive. While phages can evade defences by covalently modifying their DNA, these non-canonical nucleobases create molecular signatures tha...
Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice [0.03%]
沙门氏菌利用具有独特催化活性的硫酸盐还原酶促进小鼠肠道定植
Ju-Sim Kim,Siva Uppalapati,Alyssa Margolis et al.
Ju-Sim Kim et al.
Non-typhoidal Salmonella use molybdenum cofactor-containing MopB- or DMSO reductase-family members to respire chemically diverse substrates, including formate, nitrate and methionine sulfoxide, during infection. The DmsABC enzymatic complex...