Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases [0.03%]
重要的且可用药的激酶和蛋白酶介导巴贝斯虫细胞出芽
Brendan Elsworth,Caroline D Keroack,Yasaman Rezvani et al.
Brendan Elsworth et al.
Egress from host cells is fundamental for the spread of infection by apicomplexan parasites, including Babesia species. These tick-borne pathogens represent emerging zoonoses, but treatment options are limited. Here, using microscopy, trans...
Genomic features associated with sustained mammalian transmission of avian influenza A viruses [0.03%]
与禽流感病毒持续人际传播相关的基因组特征分析
Yongtao Ye,Huiping Shuai,Yi Song et al.
Yongtao Ye et al.
Comparably few lineages of influenza A virus (IAV) have evolved long-term sustained transmission in mammals. The reasons remain largely unknown, and the possibility of avian IAVs evolving sustained mammalian transmission is an ongoing conce...
Multi-omics reveals nitrogen dynamics associated with soil microbial blooms during snowmelt [0.03%]
基于土壤微生物组的雪融化期土壤氮动态变化解析
Patrick O Sorensen,Ulas Karaoz,Harry R Beller et al.
Patrick O Sorensen et al.
Snowmelt triggers a soil microbial bloom and crash that affects nitrogen (N) export in high-elevation watersheds. The mechanisms underlying these microbial dynamics are uncertain, making soil nitrogen processes difficult to predict as snowp...
Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation [0.03%]
效应物-宿主互作组学图谱链接健康肠道菌群中的III型分泌系统与免疫调控
Veronika Young,Bushra Dohai,Hridi Halder et al.
Veronika Young et al.
Pseudomonadota (formerly Proteobacteria) are prevalent in the commensal human gut microbiota, but also include many pathogens that rely on secretion systems to support pathogenicity by injecting proteins into host cells. Here we show that 8...
Phosphate deprivation restricts bacterial degradation of the marine polysaccharide fucoidan [0.03%]
磷酸盐缺乏限制了细菌对海洋多糖褐藻素的降解
Yi Xu,Bowei Gu,Huiying Yao et al.
Yi Xu et al.
Brown algae and diatoms convert carbon dioxide into the polysaccharide fucoidan, which sequesters carbon in the ocean despite the prevalence of marine bacterial fucoidanase genes. Bacteria with fucoidanase genes also have high-affinity phos...
Phosphate availability stabilizes fucoidan produced by marine microalgae [0.03%]
磷酸盐可用性稳定了海洋微藻产生的硫酸软骨素
Benjamin N Granzow
Benjamin N Granzow
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation [0.03%]
环境扰动引起的全球重要细菌SAR11的细胞周期失调
Chuankai Cheng,Brittany D Bennett,Pratixa Savalia et al.
Chuankai Cheng et al.
Genome streamlining is hypothesized to occur in bacteria as an adaptation to resource-limited environments but can result in gene losses affecting fundamental aspects of cellular physiology. The most abundant marine microorganisms, SAR11 (o...
Parasex generates highly recombinant progeny in Candida albicans with increased virulence [0.03%]
半性交配可增强白色念珠菌的重组和致病力
Robert J Fillinger,Abhishek Mishra,Liza Loza et al.
Robert J Fillinger et al.
Candida albicans is a major human fungal pathogen that reproduces by mitotic growth of diploid cells but can also undergo a parasexual cycle. The latter involves an uncoordinated process of ploidy reduction via aberrant mitotic divisions fo...
Bruce R Thorley
Bruce R Thorley
Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda [0.03%]
新型脊灰减毒活疫苗（nOPV2）的高稳定性：乌干达出现致神经麻痹型双重组疫苗衍生脊髓灰质炎病毒株的应对之策
Phionah Tushabe,Manasi Majumdar,Sarah Carlyle et al.
Phionah Tushabe et al.
The novel oral poliovirus vaccine type 2 (nOPV2) was developed to reduce the risk of circulating vaccine-derived poliovirus outbreaks by incorporating genetic modifications to enhance genetic stability and reduce reversion to virulence whil...