Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila [0.03%]
独特的硫酸盐适应机制赋予Akkermansia muciniphila降解结肠黏蛋白的能力
Debajit Dey,Naba D Salman,Charles W E Tomlinson et al.
Debajit Dey et al.
Excessive foraging of colonic mucin glycans by gut bacteria is associated with diseases such as inflammatory bowel disease. Although Akkermansia muciniphila is an important mucin degrader, the role of carbohydrate sulfatases that facilitate...
Antiviral GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like disease [0.03%]
一种名为GHP-88310的抗病毒药物能够阻断类似麻疹的接触传播和空气飞沫传播（小鼠模型）
Carolin M Lieber,Josef D Wolf,Claire E Ruckel et al.
Carolin M Lieber et al.
The 2025/2026 measles resurgence in North America highlighted that antivirals may be valuable in protecting child health because of mounting vaccination hesitancy. The drug candidate GHP-88310 is an orally efficacious broad-spectrum orthopa...
Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infections [0.03%]
肺炎期间介导的基因组转移导致了超强耐药菌的产生
Sardar Karash,Hannah L Betts,Matthew C Radey et al.
Sardar Karash et al.
Antibiotic resistance arising during infections is generally thought to be due to mutations in pathogen genomes. Here we studied Pseudomonas aeruginosa and Achromobacter collected from people with cystic fibrosis and non-cystic fibrosis bro...
Amal Fahmi,Isabel Schultz-Pernice,Marco P Alves
Amal Fahmi
Kirsten Küsel,Mark Dopson
Kirsten Küsel
The terrestrial subsurface hosts one of Earth's largest biomes, with groundwater systems representing major habitats for microbial life. In these environments, microbes persist under energy scarcity caused by the absence of photosynthesis, ...
Klebsiella pneumoniae inhibits vasodilation through capsule and T6SS-dependent pathways [0.03%]
肺炎克雷伯菌通过荚膜和T6SS依赖性途径抑制血管扩张
Safi Rehman,Joana Sa-Pessoa,Charlotte Buckley et al.
Safi Rehman et al.
Vasodilation is a defence mechanism during inflammation and infection that is regulated by nitric oxide produced by endothelial nitric oxide synthase (eNOS) and the generation of endothelium-dependent hyperpolarization. Several viral infect...
Clarifying objectives to strengthen wastewater-based AMR surveillance [0.03%]
澄清目标以加强基于污水的抗微生物药物耐药性监测
D G Joakim Larsson,Carl-Fredrik Flach,Ramanan Laxminarayan
D G Joakim Larsson
Molecular and cellular insights into the parasitic infection of bloom-forming marine diatoms by Pirsonia diadema [0.03%]
海洋硅藻形成水华时Pirsonia diadema感染宿主的分子机制及细胞机制研究
Varsha Mathur,Nicholas A T Irwin,Luis Javier Galindo et al.
Varsha Mathur et al.
Microbial host-parasite interactions shape global biogeochemical cycles, yet their cellular and evolutionary mechanisms remain poorly understood. Here we developed a model pathosystem to explore the interaction between the eukaryotic microp...
Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection [0.03%]
绘制细胞内蛋白质接触位点图谱揭示流感A病毒感染期间对寄生specks的劫持现象
Iuliia Kotova,Lars Mühlberg,Konstantin Gilep et al.
Iuliia Kotova et al.
Influenza A virus (IAV) hijacks host cellular machinery during infection but many host-virus protein interactions remain uncharacterized, particularly in their native context. Here, we applied in-cell cross-linking mass spectrometry, integr...
All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in mice [0.03%]
全反式维甲酸能够抑制SFTSV诱导的小鼠全身性炎症反应
Xin Yu,Jianan Wu,Xiaohong Yin et al.
Xin Yu et al.
The vitamin A metabolite all-trans retinoic acid (ATRA) has immunoregulatory features, but its systemic role during viral infection is unclear. Here we show that patients infected with severe fever with thrombocytopenia syndrome virus (SFTS...