Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia [0.03%]
蚊子在澳大利亚东南部的负鼠和人类之间提供了传播伯uli溃疡的途径
Peter T Mee,Andrew H Buultjens,Jane Oliver et al.
Peter T Mee et al.
Buruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in ...
Yersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell subpopulations [0.03%]
耶尔森氏菌Entomophaga的Tc毒素通过依赖T10SS的特殊细胞亚群裂解而释放
Oleg Sitsel,Zhexin Wang,Petra Janning et al.
Oleg Sitsel et al.
Disease-causing bacteria secrete numerous toxins to invade and subjugate their hosts. Unlike many smaller toxins, the secretion machinery of most large toxins remains enigmatic. By combining genomic editing, proteomic profiling and cryo-ele...
High-throughput transcriptomics of 409 bacteria-drug pairs reveals drivers of gut microbiota perturbation [0.03%]
409种细菌-药物对的高通量转录组学揭示了肠道微生物扰动的因素
Deirdre Ricaurte,Yiming Huang,Ravi U Sheth et al.
Deirdre Ricaurte et al.
Many drugs can perturb the gut microbiome, potentially leading to negative health consequences. However, mechanisms of most microorganism-drug responses have not been elucidated at the genetic level. Using high-throughput bacterial transcri...
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids [0.03%]
肠道共生菌基督小球菌通过羟基脂肪酸来调节宿主代谢过程
Chang Liu,Meng-Xuan Du,Li-Sheng Xie et al.
Chang Liu et al.
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host-microbe interactions in the gut remain largely unknown. Here we report...
Double-stranded RNA sequencing reveals distinct riboviruses associated with thermoacidophilic bacteria from hot springs in Japan [0.03%]
双链RNA测序揭示了来自日本热泉的嗜热嗜酸菌中不同的核糖病毒
Syun-Ichi Urayama,Akihito Fukudome,Miho Hirai et al.
Syun-Ichi Urayama et al.
Metatranscriptome sequencing expanded the known diversity of the bacterial RNA virome, suggesting that additional riboviruses infecting bacterial hosts remain to be discovered. Here we employed double-stranded RNA sequencing to recover comp...
Engineered probiotic overcomes pathogen defences using signal interference and antibiotic production to treat infection in mice [0.03%]
工程益生菌利用信号干扰和抗生素产生克服病原体防御以治疗小鼠感染
Hackwon Do,Zhong-Rui Li,Praveen Kumar Tripathi et al.
Hackwon Do et al.
Probiotic supplements are suggested to promote human health by preventing pathogen colonization. However, the mechanistic bases for their efficacy in vivo are largely uncharacterized. Here using metabolomics and bacterial genetics, we show ...
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants [0.03%]
SARS-CoV-2奥密克戎亚变异株对先天免疫抑制的增强演化
Ann-Kathrin Reuschl,Lucy G Thorne,Matthew V X Whelan et al.
Ann-Kathrin Reuschl et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted in distinct lineages with enhanced transmissibility called variants of concern (VOCs). Omicron is the first VOC to evolve distinct globally dominant subv...
Methane-dependent complete denitrification by a single Methylomirabilis bacterium [0.03%]
单一甲基莫比拉菌的完全反硝化依赖于甲烷
Xiangwu Yao,Jiaqi Wang,Mingyue He et al.
Xiangwu Yao et al.
Methane-dependent nitrate and nitrite removal in anoxic environments is thought to rely on syntrophy between ANME-2d archaea and bacteria in the genus 'Candidatus Methylomirabilis'. Here we enriched and purified a single Methylomirabilis fr...
Host-derived organic acids enable gut colonization of the honey bee symbiont Snodgrassella alvi [0.03%]
宿主衍生的有机酸促进蜂群菌Snodgrassella alvi对蜂蜜bee肠道的定植
Andrew Quinn,Yassine El Chazli,Stéphane Escrig et al.
Andrew Quinn et al.
Diverse bacteria can colonize the animal gut using dietary nutrients or by engaging in microbial crossfeeding interactions. Less is known about the role of host-derived nutrients in enabling gut bacterial colonization. Here we examined meta...
Brain glucose induces tolerance of Cryptococcus neoformans to amphotericin B during meningitis [0.03%]
脑葡萄糖在脑膜炎期间诱导新型隐球菌对两性霉素B的耐受性
Lei Chen,Xiuyun Tian,Lanyue Zhang et al.
Lei Chen et al.
Antibiotic tolerance is the ability of a susceptible population to survive high doses of cidal drugs and has been shown to compromise therapeutic outcomes in bacterial infections. In comparison, whether fungicide tolerance can be induced by...