COBRA improves the completeness and contiguity of viral genomes assembled from metagenomes [0.03%]
COBRA改进了从宏基因组中组装的病毒基因组的完整性和连续性
LinXing Chen,Jillian F Banfield
LinXing Chen
Viruses are often studied using metagenome-assembled sequences, but genome incompleteness hampers comprehensive and accurate analyses. Contig Overlap Based Re-Assembly (COBRA) resolves assembly breakpoints based on the de Bruijn graph and j...
Inga Rimkute,Natthawan Chaimongkol,Kamron D Woods et al.
Inga Rimkute et al.
Norovirus infection can cause gastrointestinal disease in humans. Development of therapies and vaccines against norovirus have been limited by the lack of a suitable and reliable animal model. Here we established rhesus macaques as an anima...
Stepwise assembly and release of Tc toxins from Yersinia entomophaga [0.03%]
_entomophaga中Tc毒素的逐步组装和释放
Miki Feldmüller,Charles F Ericson,Pavel Afanasyev et al.
Miki Feldmüller et al.
Tc toxins are virulence factors of bacterial pathogens. Although their structure and intoxication mechanism are well understood, it remains elusive where this large macromolecular complex is assembled and how it is released. Here we show by...
Mechanistic insights into bone remodelling dysregulation by human viral pathogens [0.03%]
人体病毒病原体对骨重建失调的机制见解
Camila C S Caetano,Tamiris Azamor,Nikki M Meyer et al.
Camila C S Caetano et al.
Bone-related diseases (osteopathologies) associated with human virus infections have increased around the globe. Recent findings have highlighted the intricate interplay between viral infection, the host immune system and the bone remodelli...
A framework for automated scalable designation of viral pathogen lineages from genomic data [0.03%]
从基因组数据自动扩展指定病毒病原体谱系的框架
Jakob McBroome,Adriano de Bernardi Schneider,Cornelius Roemer et al.
Jakob McBroome et al.
Pathogen lineage nomenclature systems are a key component of effective communication and collaboration for researchers and public health workers. Since February 2021, the Pango dynamic lineage nomenclature for SARS-CoV-2 has been sustained ...
The gut virome is associated with stress-induced changes in behaviour and immune responses in mice [0.03%]
肠道病毒组与压力诱导的小鼠行为和免疫反应变化相关
Nathaniel L Ritz,Lorraine A Draper,Thomaz F S Bastiaanssen et al.
Nathaniel L Ritz et al.
The microbiota-gut-brain axis has been shown to play an important role in the stress response, but previous work has focused primarily on the role of the bacteriome. The gut virome constitutes a major portion of the microbiome, with bacteri...
Predictions of rhizosphere microbiome dynamics with a genome-informed and trait-based energy budget model [0.03%]
基于基因组和性状的能量预算模型预测根际微生物组动态变化
Gianna L Marschmann,Jinyun Tang,Kateryna Zhalnina et al.
Gianna L Marschmann et al.
Soil microbiomes are highly diverse, and to improve their representation in biogeochemical models, microbial genome data can be leveraged to infer key functional traits. By integrating genome-inferred traits into a theory-based hierarchical...
Prioritizing mentorship [0.03%]
重视导师指导
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data [0.03%]
microbeMASST：一种用于微生物代谢组学数据的基于分类学指导的质谱搜索工具
Simone Zuffa,Robin Schmid,Anelize Bauermeister et al.
Simone Zuffa et al.
microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can se...
Dolma Michellod,Manuel Liebeke
Dolma Michellod