Bridging continuous and discrete evolution through a controllable, hypermutagenic phage-bacteria system [0.03%]
通过可控、超突变的噬菌体-细菌系统连接连续进化和离散进化
Shujian Ong,Pramila Ghode,Ashvinath Narenderan et al.
Shujian Ong et al.
Directed evolution methods face trade-offs between the control of discrete approaches and the throughput of modern continuous systems. Here, we engineered a method called lytic selection and evolution (LySE) for near-continuous evolution of...
Cass D Condray,Kira L Newman
Cass D Condray
Melissa J Martin,Francois Lebreton
Melissa J Martin
Streptomyces produce a diphtheria toxin-like exotoxin that targets insects [0.03%]
链霉菌产生类似白喉毒素的外毒素来靶向昆虫
Ying Xu,Reed M Stubbendieck,Raghuvir Viswanatha et al.
Ying Xu et al.
Streptomyces and insects engage in complex interactions shaped by millions of years of evolution. While many beneficial relationships are well recognized, it remains unknown whether Streptomyces produce virulence factors targeting insects s...
Author Correction: Unbinned contigs expand known diversity in the global microbiome [0.03%]
作者更正：未划分 bins 的重叠群集可扩大全球微生物组中已知的多样性
Vishnu Prasoodanan Pk,Oleksandr M Maistrenko,Anthony Fullam et al.
Vishnu Prasoodanan Pk et al.
Published Erratum
Nature microbiology. 2026 Apr 27. DOI:10.1038/s41564-026-02354-y 2026
Nuclease-NTPase antiphage defence systems use conserved molecular features to control bacterial immunity [0.03%]
核酸酶-ntp酶反噬菌体防御系统利用保守的分子特征控制细菌免疫性
Adelyn E Ragucci,Sadie P Antine,Ethan M Leviss et al.
Adelyn E Ragucci et al.
Bacteria encode diverse defence systems, including restriction-modification and CRISPR-Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence oper...
Strain-level transmission inference across multi-kingdom metagenomic data using TRACS [0.03%]
基于TRACS的跨多界元基因组数据的菌株水平传播推断
Gerry Tonkin-Hill,Yan Shao,Alexander E Zarebski et al.
Gerry Tonkin-Hill et al.
Coexisting strains of the same species within metagenomic data pose a substantial challenge to inferring transmission of pathogenic and commensal microbes. Here we present TRAnsmision Clustering of Strains (TRACS), a highly accurate algorit...
Community context reshapes microbial proteomes and reduces functional overlap [0.03%]
群落环境重塑微生物蛋白质组并降低功能重叠现象
Sarah Moraïs,Michael Mazor,Itai Amit et al.
Sarah Moraïs et al.
Microbial coexistence in complex communities requires mechanisms that minimize competition and optimize resource use. However, the mechanisms by which these ecological strategies are executed remain poorly understood. Here we show that bact...
Cayman enables large-scale analysis of gut microbiome carbohydrate-active enzyme repertoires [0.03%]
凯曼分析肠道微生物组糖基水解酶格局
Quinten R Ducarmon,Nicolai Karcher,Samir Giri et al.
Quinten R Ducarmon et al.
Carbohydrate-active enzymes (CAZymes) are crucial for digesting glycans, but tools for CAZyme profiling and interpretation of substrate preferences in microbiome data are lacking. Here we develop a CAZyme profiler called Cayman (Carbohydrat...