Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex [0.03%]
产红色似serratia菌群的全球人群结构及其医院适应谱系的鉴定
Tomoyuki Ono,Itsuki Taniguchi,Keiji Nakamura et al.
Tomoyuki Ono et al.
Serratia marcescens is an important nosocomial pathogen causing various opportunistic infections, such as urinary tract infections, bacteremia and sometimes even hospital outbreaks. The recent emergence and spread of multidrug-resistant (MD...
Kaptive 2.0: updated capsule and lipopolysaccharide locus typing for the Klebsiella pneumoniae species complex [0.03%]
Kaptive 2.0：更新了肺炎克雷伯菌复合体的胶囊和脂多糖基因型分类系统
Margaret M C Lam,Ryan R Wick,Louise M Judd et al.
Margaret M C Lam et al.
The outer polysaccharide capsule and lipopolysaccharide (LPS) antigens are key targets for novel control strategies targeting Klebsiella pneumoniae and related taxa from the K. pneumoniae species complex (KpSC), including vaccines, phage an...
Genomic diversity and antimicrobial resistance among non-typhoidal Salmonella associated with human disease in The Gambia [0.03%]
冈比亚致人类疾病的非伤寒沙门氏菌的基因组多样性及抗微生物药物耐药性
Saffiatou Darboe,Richard S Bradbury,Jody Phelan et al.
Saffiatou Darboe et al.
Non-typhoidal Salmonella associated with multidrug resistance cause invasive disease in sub-Saharan Africa. Specific lineages of serovars Typhimurium and Enteritidis have been implicated. Here we characterized the genomic diversity of 100 c...
Finding the right fit: evaluation of short-read and long-read sequencing approaches to maximize the utility of clinical microbiome data [0.03%]
寻找合适的方法：评估短读和长读测序方法以最大化临床微生物组数据的效用
Jeanette L Gehrig,Daniel M Portik,Mark D Driscoll et al.
Jeanette L Gehrig et al.
A long-standing challenge in human microbiome research is achieving the taxonomic and functional resolution needed to generate testable hypotheses about the gut microbiota's impact on health and disease. With a growing number of live microb...
Genomic and antigenic diversity of colonizing Klebsiella pneumoniae isolates mirrors that of invasive isolates in Blantyre, Malawi [0.03%]
马拉维布兰太尔的定植型肺炎克雷伯菌基因组和抗原组多样性与入侵型菌株相似
Joseph M Lewis,Madalitso Mphasa,Rachel Banda et al.
Joseph M Lewis et al.
Members of the Klebsiella pneumoniae species complex, particularly K. pneumoniae subsp. pneumoniae are antimicrobial resistance (AMR) associated pathogens of global importance, and polyvalent vaccines targeting Klebsiella O-antigens are in ...
Novel canine high-quality metagenome-assembled genomes, prophages and host-associated plasmids provided by long-read metagenomics together with Hi-C proximity ligation [0.03%]
由长读测序联合Hi-C邻近连接测序提供的新型高质量犬类宏基因组组装基因组、前噬菌体和宿主相关质粒
Anna Cuscó,Daniel Pérez,Joaquim Viñes et al.
Anna Cuscó et al.
The human gut microbiome has been extensively studied, yet the canine gut microbiome is still largely unknown. The availability of high-quality genomes is essential in the fields of veterinary medicine and nutrition to unravel the biologica...
Methods for the targeted sequencing and analysis of integrons and their gene cassettes from complex microbial communities [0.03%]
用于从复杂的微生物群落中对整合子及其基因 cassette 进行靶向测序和分析的方法
Timothy M Ghaly,Anahit Penesyan,Alexander Pritchard et al.
Timothy M Ghaly et al.
Integrons are microbial genetic elements that can integrate mobile gene cassettes. They are mostly known for spreading antibiotic resistance cassettes among human pathogens. However, beyond clinical settings, gene cassettes encode an extrao...
Meta-analysis of the Ralstonia solanacearum species complex (RSSC) based on comparative evolutionary genomics and reverse ecology [0.03%]
基于比较进化基因组学和逆向生态学的Ralstonia solanacearum物种复合体（RSSC）的meta分析
Parul Sharma,Marcela A Johnson,Reza Mazloom et al.
Parul Sharma et al.
Ralstonia solanacearum species complex (RSSC) strains are bacteria that colonize plant xylem tissue and cause vascular wilt diseases. However, individual strains vary in host range, optimal disease temperatures and physiological traits. To...
Meta-Analysis
Microbial genomics. 2022 Mar;8(3):000791. DOI:10.1099/mgen.0.000791 2022
Unusual SARS-CoV-2 intrahost diversity reveals lineage superinfection [0.03%]
异常的SARS-CoV-2宿主内多样性揭示出谱系超感染现象
Filipe Zimmer Dezordi,Paola Cristina Resende,Felipe Gomes Naveca et al.
Filipe Zimmer Dezordi et al.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected almost 200 million people worldwide by July 2021 and the pandemic has been characterized by infection waves of viral lineages showing distinct fitness profiles. The s...
Targeted Sanger sequencing to recover key mutations in SARS-CoV-2 variant genome assemblies produced by next-generation sequencing [0.03%]
下一代测序产生的SARS-CoV-2变异基因组组装的靶向桑格尔测序以获取关键突变
Lavanya Singh,James E San,Houriiyah Tegally et al.
Lavanya Singh et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is adaptively evolving to ensure its persistence within human hosts. It is therefore necessary to continuously monitor the emergence and prevalence of novel variants that arise. I...