Gene presence-absence and evolutionary signals of positive selection associated with virulence divergence in Beauveria fungi [0.03%]
芽孢菌属虫生真菌的毒力分化相关基因存在-缺失变异和正选择信号分析
Teeratas Kijpornyongpan,Nuntanat Arnamnart,Papichaya Kwantong et al.
Teeratas Kijpornyongpan et al.
Beauveria bassiana is widely used as a mycoinsecticide and studied for its pathogenic mechanisms. However, the virulence biology of other Beauveria species remains poorly understood. In this study, we conducted comparative pathological and ...
Integrated analysis of transposon insertion sequencing and pangenome reveals core and lineage-specific essential genes in Mycobacterium avium subsp. hominissuis [0.03%]
跳跃基因插入测序和泛基因组的综合分析揭示了 MAP 核心必需基因及谱系特异性分布规律
Kotaro Sawai,Marie Ikai,Motoko Shinohara et al.
Kotaro Sawai et al.
Pulmonary disease caused by non-tuberculous mycobacteria (NTM-PD) is an emerging global health concern. Among NTM, Mycobacterium avium subsp. hominissuis (MAH) is the major causative agent of NTM-PD. Similar to Mycobacterium tuberculosis, M...
A maize-associated Rhizobium miluonense fixes nitrogen in free-living conditions through an exopolysaccharide-dependent biofilm mechanism [0.03%]
一种与玉米相关的地米固氮菌通过依赖胞外多糖的生物被膜机制在游离生活条件下固定氮气
Esau De la Vega-Camarillo,Jossue Ortíz-Álvarez,Juan Alfredo Hernández-García et al.
Esau De la Vega-Camarillo et al.
Rhizobium miluonense WD29, isolated from the rhizosphere of Jala landrace maize (Mexico), demonstrates FLNF, an unusual trait for this typically symbiotic genus. Whole-genome sequencing revealed a 6.8 Mb genome (59.7% GC) with 6,908 protein...
A standardized core genome multilocus sequence typing and life identification number barcoding framework for global Pasteurella multocida surveillance and outbreak investigation [0.03%]
用于全球猪多杀性巴氏杆菌监测和爆发调查的标准化核心基因组多位点序列分型及生命识别编码框架
Angela V Lopez Garcia,Keith A Jolley,Kasia M Parfitt et al.
Angela V Lopez Garcia et al.
Effective pathogen surveillance requires robust typing systems for outbreak detection and understanding transmission dynamics, evolutionary patterns, host colonization and disease progression. Pasteurella multocida is a globally distributed...
Downregulation is the dominant effect of new regulatory mutations in a fungal pathogen [0.03%]
新的调控突变在真菌病原体中的主要效应是下调表达
Ana Margarida Sampaio,Daniel Croll
Ana Margarida Sampaio
Well-tuned gene regulation is essential for an organism's survival. However, the ancestral state and predominant effects of regulatory mutations remain poorly understood outside of model fungi, such as Baker's yeast with a highly compact ge...
Reference-free clustering as an epidemiological tool for Mycobacterium tuberculosis lineage typing [0.03%]
无参考谱系分型方法在结核杆菌进化及传播研究中的应用
Aureliana F C Chilengue,Daniel J Whiley,Kate Cox et al.
Aureliana F C Chilengue et al.
Whole-genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) is widely used in epidemiological investigations of recent transmission events, resulting in high-resolution strain typing. Accurate and rapid strain typing is essential for ...
Epidemiological characterization and phylogenetic analysis of human metapneumovirus isolated from children in Ningbo, China, 2020-2024 [0.03%]
2020-2024年我国宁波地区人偏肺病毒的分子流行特征及进化分析
Yongdong Li,Rui Liu,Lei Xie et al.
Yongdong Li et al.
Human metapneumovirus (hMPV) is an important cause of acute respiratory infections in children, but genomic surveillance data from Ningbo, a coastal port city of China, remain limited. We investigated the epidemiology, genetic diversity and...
A more complete picture: capturing single nucleotide variant diversity in extended-spectrum beta-lactamase producing Escherichia coli using post-enrichment metagenomics [0.03%]
更完整的图景：利用富集后元基因组学方法捕获产超广谱β内酰胺酶大肠埃希氏杆菌的单核苷酸变异多样性
Sarah Gallichan,Tommi Mäklin,Esther Picton-Barlow et al.
Sarah Gallichan et al.
Inferring transmission relies on accurately distinguishing between isolates from the same source and those from different sources, and high-quality genomic data are frequently used to model transmission scenarios. The post-enrichment metage...
NanoPop: Nanopore amplicon sequencing of Salmonella virulence genes to characterize complex mixed serovar populations using k-mers to overcome high sequencing error rates [0.03%]
基于纳米孔扩增子测序的沙门氏菌毒力基因快速表型分型方法研究：利用k-mer克服高错误率识别复杂混合血清型群体
David Ayala-Velastegui,Tatum D Mortimer,Amy T Siceloff et al.
David Ayala-Velastegui et al.
Salmonella enterica comprises over 2,600 genetically distinct serovars, of which 20 are associated with 70% of human illnesses. In food animal production systems, including poultry, mixed serovars commonly exist. Therefore, culture-based ap...
Genomic analysis of environmentally sourced Stenotrophomonas species from Fiji and Australia [0.03%]
来自斐济和澳大利亚的环境来源的Stenotrophomonas物种的基因组分析
Ethan R Wyrsch,Barbara Drigo,Dmitriy Li et al.
Ethan R Wyrsch et al.
The World Health Organization identified Stenotrophomonas maltophilia as an underestimated, multi-drug-resistant and opportunistic nosocomial pathogen. It poses a threat to patients who are immunocompromised, suffering chronic disease, requ...