Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae [0.03%]
肺炎链球菌中一个可移动的遗传元件对溶血素产生的靶向控制
Emily J Stevens,Daniel J Morse,Dora Bonini et al.
Emily J Stevens et al.
Streptococcus pneumoniae is a major human pathogen that can cause severe invasive diseases such as pneumonia, septicaemia and meningitis. Young children are at a particularly high risk, with an estimated 3-4 million cases of severe disease ...
Jane Hawkey,Hugh Cottingham,Alex Tokolyi et al.
Jane Hawkey et al.
Linear plasmids are extrachromosomal DNA elements that have been found in a small number of bacterial species. To date, the only linear plasmids described in the family Enterobacteriaceae belong to Salmonella, first found in Salmonella ente...
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types [0.03%]
哌拉西林他唑巴坦耐药但头孢类敏感的大肠埃希菌血流感染株的获得性多药抗性驱动了多种序列型的发展
Thomas Edwards,Eva Heinz,Jon van Aartsen et al.
Thomas Edwards et al.
Resistance to piperacillin/tazobactam (TZP) in Escherichia coli has predominantly been associated with mechanisms that confer resistance to third-generation cephalosporins. Recent reports have identified E. coli strains with phenotypic resi...
In silico capsule locus typing for serovar prediction of Actinobacillus pleuropneumoniae [0.03%]
刺鼠胸膜肺炎放线杆菌血清型基因分型的计算机分析方法
Siou-Cen Li,Jing-Fang Huang,Yu-Ting Hung et al.
Siou-Cen Li et al.
Actinobacillus pleuropneumoniae is a causative agent of pleuropneumonia in pigs of all ages. A . pleuropneumoniae is divided into 19 serovars based on capsular polysaccharides (CPSs) and lipopolysaccharides. The serovars of isolates are...
Pathogenomes and variations in Shiga toxin production among geographically distinct clones of Escherichia coli O113:H21 [0.03%]
志贺毒素产生菌基因组和变异地理不同的O113:H21大肠杆菌克隆中的志贺毒素产生菌基因组和变异
Anna Allué-Guardia,Sara S K Koenig,Ricardo A Martinez et al.
Anna Allué-Guardia et al.
Infections with globally disseminated Shiga toxin-producing Escherichia coli (STEC) of the O113:H21 serotype can progress to severe clinical complications, such as hemolytic uremic syndrome (HUS). Two phylogeographically distinct clonal com...
Dissemination of a single ST11 clone of OXA-48-producing Klebsiella pneumoniae within a large polyclonal hospital outbreak determined by genomic sequencing [0.03%]
基于基因组测序的产OXA-48型酶肺炎克雷伯菌ST11单株在大型多克隆医院暴发中的传播分析
Fernando Lázaro-Perona,Elias Dahdouh,Alma Sotillo et al.
Fernando Lázaro-Perona et al.
The population structure of a set of OXA-48-producing Klebsiella pneumoniae isolates belonging to sequence type 11 (ST11 Kp-OXA) and obtained from two hospitals in Madrid in the period from 2012 to 2015 was studied by genome sequencing. O...
K-mer based prediction of Clostridioides difficile relatedness and ribotypes [0.03%]
基于K-mer的艰难梭菌相关性和血清型预测
Matthew Phillip Moore,Mark H Wilcox,A Sarah Walker et al.
Matthew Phillip Moore et al.
Comparative analysis of Clostridioides difficile whole-genome sequencing (WGS) data enables fine scaled investigation of transmission and is increasingly becoming part of routine surveillance. However, these analyses are constrained by the ...
A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV [0.03%]
一种与肺炎链球菌结合疫苗（PCV）血清型通常相关的肺炎链球菌谱系是南非在常规使用PCV后导致血清型35B侵袭性疾病的最常见原因
Kedibone M Ndlangisa,Mignon du Plessis,Stephanie Lo et al.
Kedibone M Ndlangisa et al.
Pneumococcal serotype 35B is an important non-conjugate vaccine (non-PCV) serotype. Its continued emergence, post-PCV7 in the USA, was associated with expansion of a pre-existing 35B clone (clonal complex [CC] 558) along with post-PCV13 eme...
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage [0.03%]
基因组学在低抗生素使用量的生猪养殖场探索抗药性持续存在的运用
Nathaniel Storey,Shaun Cawthraw,Olivia Turner et al.
Nathaniel Storey et al.
Food animals may be reservoirs of antimicrobial resistance (AMR) passing through the food chain, but little is known about AMR prevalence in bacteria when selective pressure from antimicrobials is low or absent. We monitored antimicrobial-r...
Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017 [0.03%]
里弗型017产芽胞难辨梭菌的全球进化动力学及抗性基因分析
Korakrit Imwattana,Papanin Putsathit,Deirdre A Collins et al.
Korakrit Imwattana et al.
Clostridioides difficile PCR ribotype (RT) 017 ranks among the most successful strains of C. difficile in the world. In the past three decades, it has caused outbreaks on four continents, more than other ‘epidemic’ strains, but our und...