IS 26-mediated plasmid reshuffling results in convergence of toxin-antitoxin systems but loss of resistance genes in XDR Klebsiella pneumoniae from a chronic infection [0.03%]
泛耐药型肺炎克雷伯菌中由IS26介导的质粒重组导致毒力-抗毒力系统趋同化和耐药基因丢失：来自慢性感染的证据
Ting L Luo,Brendan W Corey,Erik Snesrud et al.
Ting L Luo et al.
Carbapenem-resistant Enterobacterales pose an urgent threat to human health worldwide. Klebsiella pneumoniae sequence type (ST) 14, initially identified in the Middle East and South-Asia and co-harbouring the carbapenemase genes bla OXA-232...
Comparative genomics of Rothia species reveals diversity in novel biosynthetic gene clusters and ecological adaptation to different eukaryotic hosts and host niches [0.03%]
罗氏菌属物种比较基因组学揭示了新颖生物合成基因簇和适应不同真核宿主及其生态位的多样性
Isabela M Fernandes de Oliveira,Duncan Y K Ng,Peter van Baarlen et al.
Isabela M Fernandes de Oliveira et al.
Rothia species are understudied members of the phylum Actinobacteria and prevalent colonizers of the human and animal upper respiratory tract and oral cavity. The oral cavity, including the palatine tonsils, is colonized by a complex microb...
Emerging patterns of fluoroquinolone resistance in Campylobacter jejuni in the UK [1998-2018] [0.03%]
英国Campylobacter jejuni菌株氟喹诺酮耐药性新模式（1998—2018）
Dessislava Veltcheva,Frances M Colles,Margaret Varga et al.
Dessislava Veltcheva et al.
Campylobacter jejuni (C.jejuni) is the most common causative agent of bacterial food poisoning worldwide and is known to be genetically highly diverse. C. jejuni is increasingly resistant to fluoroquinolone antibiotics, but very few studies...
Genome analysis of a new sulphur disproportionating species Thermosulfurimonas strain F29 and comparative genomics of sulfur-disproportionating bacteria from marine hydrothermal vents [0.03%]
硫化物分档物种Thermosulfurimonas菌株F29的基因组分析及海洋热液喷口硫化物分档细菌的比较基因组学研究
Maxime Allioux,Stéven Yvenou,Anne Godfroy et al.
Maxime Allioux et al.
This paper reports on the genome analysis of strain F29 representing a new species of the genus Thermosulfurimonas. This strain, isolated from the Lucky Strike hydrothermal vent field on the Mid-Atlantic Ridge, is able to grow by disproport...
dRNASb: a systems biology approach to decipher dynamics of host-pathogen interactions using temporal dual RNA-seq data [0.03%]
基于时间序列双RNA测序数据解译宿主-病原体相互作用动态的系统生物学方法
Mojdeh Dinarvand,Forrest C Koch,Daniel Al Mouiee et al.
Mojdeh Dinarvand et al.
Infection triggers a dynamic cascade of reciprocal events between host and pathogen wherein the host activates complex mechanisms to recognise and kill pathogens while the pathogen often adjusts its virulence and fitness to avoid eradicatio...
Naturally occurring Neisseria gonorrhoeae can have large deletions in housekeeping gene abcZ, making them untypable with multilocus sequence typing [0.03%]
自然产生的淋病奈瑟菌在管家基因abcZ中可以有大片段的缺失，因而多态位点序列分型无法对其进行分型
Hilde Synnøve Vollan,Dominique A Caugant,Vegard Eldholm et al.
Hilde Synnøve Vollan et al.
The abcZ gene is an essential housekeeping gene in all the Neisseria species. It is one of the seven genes used for multilocus sequence typing (MLST) this genus. It encodes the cytosolic component of an ATP-binding cassette (ABC) transporte...
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents [0.03%]
从全球卫生角度探索两大陆上粪肠球菌的可移动基因组和抗性基因组
Haley Sanderson,Kristen L Gray,Alexander Manuele et al.
Haley Sanderson et al.
Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (...
The histone code of the fungal genus Aspergillus uncovered by evolutionary and proteomic analyses [0.03%]
通过进化和蛋白质组分析揭示曲霉属的组蛋白密码
Xin Zhang,Roberta Noberini,Tiziana Bonaldi et al.
Xin Zhang et al.
Chemical modifications of DNA and histone proteins impact the organization of chromatin within the nucleus. Changes in these modifications, catalysed by different chromatin-modifying enzymes, influence chromatin organization, which in turn ...
In silico identification of bacterial seaweed-degrading bioplastic producers [0.03%]
利用计算机识别海洋细菌中降解海藻的生物塑料产物
Daniel R Leadbeater,Neil C Bruce,Thierry Tonon
Daniel R Leadbeater
There is an urgent need to replace petroleum-based plastic with bio-based and biodegradable alternatives. Polyhydroxyalkanoates (PHAs) are attractive prospective replacements that exhibit desirable mechanical properties and are recyclable a...
Single-cell genomics reveals population structures from in vitro evolutionary studies of Salmonella [0.03%]
单细胞基因组学揭示了三甲胺N-氧化物介导的沙门氏菌体外进化研究中的种群结构
Matt Bawn,Johana Hernandez,Eleftheria Trampari et al.
Matt Bawn et al.
Single-cell DNA sequencing has the potential to reveal detailed hierarchical structures in evolving populations of cells. Single cell approaches are increasingly used to study clonal evolution in human ageing and cancer but have not yet bee...