Evidence supporting the first secondary chromosome in Actinobacteria as a hallmark of the Embleya genus [0.03%]
支持放线菌中的第一个次级染色体作为Embleya属的标志的证据
Juan Pablo Gomez-Escribano,Siobhán Dorai-Raj,David Baker et al.
Juan Pablo Gomez-Escribano et al.
Embleya is a genus within the family Streptomycetaceae, a group of Actinobacteria with an outstanding capacity for the production of specialized metabolites, and a strikingly complex life cycle. In this work, we sequenced the complete genom...
First report of a nosocomial outbreak of ST101 Klebsiella pneumoniae carrying bla OXA-48 in Shandong, China [0.03%]
中国山东首次报道一起产OXA-48型碳青霉烯酶肺炎克雷伯菌ST101型医院感染暴发事件
Wanxiang Li,Qizhao Gao,Jie Ma et al.
Wanxiang Li et al.
Objectives. Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains harbouring bla KPC and bla NDM are prevalent in China, while bla OXA-48-positive CRKP remains uncommon. This study reports one of the first outbreaks of a nosocomial infe...
Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK [0.03%]
全基因组测序在英国一个成人重症监护病房中用于调查多重耐药革兰阴性病原体的流行和传播
Hayley J Wilson,Petra Polgarova,Fahad A Khokhar et al.
Hayley J Wilson et al.
Background. Rates of multidrug resistance (MDR) in Gram-negative bacteria (GNB), particularly those harbouring extended-spectrum beta-lactamases (ESBL) and/or carbapenemases, are increasing globally. Intensive care unit (ICU) patients are v...
Comparative genomics and molecular insights into smooth and rough clinical isolates of Mycobacterium abscessus [0.03%]
比较基因组学和分子见解平滑菌株和粗糙菌株临床分离的鸟分枝杆菌脓肿亚种
Rajender Kumar,Clara Braian,Gabrielle Fröberg et al.
Rajender Kumar et al.
Background. Our recent findings indicate that the rough form of the Mycobacterium abscessus complex (MABC) is associated with worse clinical outcomes compared to the smooth variant. The glycopeptidolipid (GPL) locus has been considered vita...
Comparative Study
Microbial genomics. 2026 May;12(5). DOI:10.1099/mgen.0.001687 2026
Genomic comparison of clinical strains of Mycobacterium shinjukuense in Japan reveals low diversity and stable genome structures [0.03%]
日本临床分枝杆菌新宿亚种的基因组比较显示低多样性及稳定的基因组结构
Takayuki Wada,Hiharu Inoue,Shiomi Yoshida et al.
Takayuki Wada et al.
Mycobacterium shinjukuense, a rare non-tuberculous mycobacterial species closely related to Mycobacterium tuberculosis, remains poorly characterized at the genomic level. To obtain insights into its intraspecies genomic diversity and struct...
Comparative Study
Microbial genomics. 2026 May;12(5):001695. DOI:10.1099/mgen.0.001695 2026
Phylogenomics and gene association analysis support probiotic potential in a subset of Staphylococcus xylosus isolates [0.03%]
菌株组的系统发育基因组和基因关联分析支持其潜在益生菌属性
Kaylee Dawn Rich,Zhangbin Cai,Diego B Nobrega et al.
Kaylee Dawn Rich et al.
Mastitis is a major disease in dairy cattle, often caused by Staphylococcus aureus infection and increasingly complicated by antimicrobial resistance. As a result, bacterial strains able to effectively provide colonization resistance in the...
Decentralized nanopore genomics reveals diverse Klebsiella pneumoniae and no evidence of patient-patient transmission in a New Zealand hospital [0.03%]
基于纳米孔测序的去中心化基因组学揭示了新西兰医院中多样化的肺炎克雷伯菌且没有患者间传播的证据
Rhys T White,Sarah Bakker,Megan Burton et al.
Rhys T White et al.
Klebsiella pneumoniae is a leading cause of healthcare-associated infections worldwide, yet its population structure and transmission dynamics remain largely uncharacterized in New Zealand hospitals. We conducted a 15-month prospective geno...
Metagenomic analysis of UK retail foods finds limited evidence for associations between food production method and antimicrobial resistance gene burden [0.03%]
英国零售食品的元基因组分析表明，食品生产方法和耐药基因负担之间的关系证据有限
Sam A Mellor,Samuel J Bloomfield,Raphaëlle Palau et al.
Sam A Mellor et al.
Food is produced by a range of methods including extensive (organic and free range), intensive (conventional) and wild-caught production systems. Antimicrobial use varies between different food production systems, which may affect the micro...
Nanopore direct RNA sequencing reveals transmissible gastroenteritis virus epitranscriptomic and transcriptomic landscapes modulated by gene 7 [0.03%]
纳米孔直接RNA测序揭示了由基因7调控的传染性胃肠炎病毒表转录组和转录组图谱
Qingqiu Jiang,Zhihao Guo,Lu Tan et al.
Qingqiu Jiang et al.
Viral non-structural proteins are key mediators of host-virus interplay, including RNA modification dynamics. The function of the transmissible gastroenteritis virus (TGEV) gene 7, which encodes a non-structural protein, remains poorly unde...
Genomic features and the transcriptional regulation of secondary metabolite biosynthesis of endophytic fungus Xylaria sp. VDL4 isolated from Vaccinium dunalianum [0.03%]
从越橘中分离出的内生真菌Xylaria sp. VDL4次级代谢产物生物合成的基因组特征及转录调控研究
Lu Li,Xiaolong Yuan,Zhonghua Chen et al.
Lu Li et al.
As a prominent group of endophytic fungi, Xylaria species have attracted considerable research interest due to their capacity to produce diverse bioactive secondary metabolites. In this study, we performed comprehensive whole-genome sequenc...