Using pangenome variation graphs to improve mutation detection in a large DNA virus [0.03%]
利用泛基因组变异图改进大型DNA病毒中的突变检测
Tim Downing,Chandana Tennakoon,Lidia Lasecka-Dykes et al.
Tim Downing et al.
Accurately quantifying viral genetic diversity is essential for understanding pathogen evolution, transmission and emergence. However, standard approaches that map sequencing reads to a single linear reference genome introduce substantial r...
Unveiling metagenomic and metabolomic signatures in mild and severe pneumonia caused by Mycoplasma pneumoniae in children [0.03%]
儿童支原体肺炎轻型和重型的元基因组和代谢组特征分析
Yeran Yang,Shitao Lian,Xiao Li et al.
Yeran Yang et al.
Background. Mycoplasma pneumoniae (MP) is a common causative pathogen of community-acquired pneumonia in children, with clinical presentations ranging in severity. Early stratification and timely intervention are essential for improving pat...
Towards accurate genomic detection of fungal antimicrobial resistance: progress in fungal resistance databases and bioinformatic tools [0.03%]
迈向准确的真菌抗微生物基因组检测：真菌耐药数据库和生物信息学工具的研究进展
Andrew P Gador-Whyte,Johanna Rhodes,Rhys A Farrer et al.
Andrew P Gador-Whyte et al.
Fungal antimicrobial resistance (fAMR) is increasing worldwide and is recognized as a global health priority by the World Health Organization. The emergence of Candidozyma (Candida) auris and other resistant fungal pathogens presents a risk...
Uncovering resistance pathways to first- and last-line antibiotics in Mycobacterium tuberculosis populations [0.03%]
揭示结核分枝杆菌菌群中一线和二线抗生素的耐药途径
Prapaporn Srilohasin,Jasmine M Williams,Aidan P Tay et al.
Prapaporn Srilohasin et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the world's deadliest diseases, currently responsible for ~1.5 million deaths per year and rising. Recently, rifampicin-resistant M. tuberculosis was designated as a critica...
Genetic structure of penicillin non-susceptible invasive Streptococcus pneumoniae in Colombia [0.03%]
哥伦比亚耐青霉素侵袭性肺炎链球菌的遗传结构
Jamie Moreno,Johan F Bernal,Monica Abrudan et al.
Jamie Moreno et al.
Background. Infections caused by Streptococcus pneumoniae are a public health problem worldwide, and penicillin-non-susceptible isolates are a priority for the World Health Organization, which requires further research and development of ne...
Phylogenomic and metabolic insights into iron reduction metabolism in the genus Deferribacter belonging to the order Deferribacterales [0.03%]
铁还原菌属铁还原代谢的生理基因组和代谢见解
Eva Pouder,Karine Alain,Sophie Mieszkin
Eva Pouder
Iron is one of the most important elements of the Earth, yet its bioavailability is limited in oceanic environments. In this context, deep-sea hydrothermal ecosystems represent one of the major sources of iron. While some microorganisms inv...
Conservation, origin, and remodeling of the phenyl acetate degradation pathway [0.03%]
苯乙酸降解途径的保护、起源和重建
Jimena Arreola-Calderon,Juan-Manuel Hurtado-Ramirez,Erick Cruz-Santiago et al.
Jimena Arreola-Calderon et al.
Aromatic hydrocarbons are widespread environmental compounds whose microbial degradation is essential for detoxification, yet the genomic distribution and evolutionary stability of many catabolic pathways remain poorly understood. The pheny...
Comparative genomics reveals high prophage diversity and horizontal gene transfer of effectors and phage defence systems in the Pseudomonas syringae complex [0.03%]
比较基因组学揭示了假单胞菌丁香环斑种内有高度多样性的原噬菌体及效应物和噬菌体防御系统之间的水平基因转移现象
Dominique Holtappels,George E J Rickus,Túlio Morgan et al.
Dominique Holtappels et al.
The mobilome, defined as the collection of mobile genetic elements within a bacterial genome, plays a role in the adaptation of bacteria to abiotic and biotic drivers. In particular, prophages have been reported to contribute to bacterial r...
Comparative Study
Microbial genomics. 2026 May;12(5):001711. DOI:10.1099/mgen.0.001711 2026
Integrative analysis of fitness and metabolic effects of a large multidrug-resistant plasmid in Salmonella across diverse serovars [0.03%]
整合分析了大型多药耐药质粒在不同血清型沙门氏菌中的适应度和代谢效应
Yu-Ting Su,Zi-Xuan Li,Peng-Wei Li et al.
Yu-Ting Su et al.
Plasmids, particularly those of the IncHI2 type, are key drivers of multidrug resistance in Salmonella. However, the fitness costs imposed by multidrug-resistant (MDR) IncHI2 plasmids across different serovars and the underlying mechanisms ...
Characterization of Ornithobacterium hominis colonization dynamics and interaction with the nasopharyngeal microbiome in a South African birth cohort [0.03%]
南非出生队列中Ornithobacterium hominis定植动力学及其与鼻咽微生物组相互作用的特征描述
Celine C De Allende,Susannah J Salter,Siobhan E Brigg et al.
Celine C De Allende et al.
Ornithobacterium hominis is a recently described Gram-negative bacterium that colonizes the human nasopharynx and may be associated with poor upper respiratory tract health. Here, we describe the isolation of O. hominis from samples collect...