Diversity and functional characterization of HNH endonucleases encoded by lactococcal Skunavirus phages [0.03%]
乳酸菌Skunavirus噬菌体编码的HNH内切酶多样性及功能表征
Jun-Hyeok Yu,Christian Cambillau,Gabriele Andrea Lugli et al.
Jun-Hyeok Yu et al.
Homing, a biological phenomenon involving enzyme-mediated genetic exchange by homologous recombination, has been highlighted as a potential driver of phage genome evolution. In the current study, 18 lactococcal phages, belonging to the Skun...
Sequencing and variant calling of SARS-CoV-2 from floor swabs: a potential tool for identifying emergent lineages [0.03%]
从地面抹布样本进行新冠病毒基因测序及变异分析：识别新的病毒谱系的潜在工具
Benazir Hodzic-Santor,Aaron Hinz,Rees Kassen et al.
Benazir Hodzic-Santor et al.
Ongoing viral evolution is a key driver of global pandemics, such as COVID-19, contributing to the repeated emergence and spread of new variants of concern. Identifying emerging viral variants is crucial for controlling the spread of infect...
Predicting clinical outcome of Escherichia coli O157:H7 infections using explainable machine learning [0.03%]
使用可解释的机器学习预测大肠杆菌O157:H7感染的临床结局
Julian A Paganini,Suniya Khatun,Sean McAteer et al.
Julian A Paganini et al.
Shiga toxin-producing Escherichia coli (STEC) O157:H7 is a globally dispersed zoonotic pathogen capable of causing severe disease outcomes, including bloody diarrhoea and haemolytic uraemic syndrome. While variations in Shiga toxin subtype ...
IS 1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium [0.03%]
肠球菌中的IS1216驱动pRUM类多药耐药质粒的进化
Freya Allen,Ross S McInnes,Willem van Schaik et al.
Freya Allen et al.
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium, but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of two clinical E. faecium strains isolated i...
Paired-omics-based exploration and characterization of biosynthetic diversity in lichenized fungi [0.03%]
基于配对组学的地衣化菌类生物合成多样性的探索与表征
Garima Singh,Maonian Xu,Mitja Zdouc et al.
Garima Singh et al.
The increasing demand for novel drug leads requires bioprospecting non-model taxa. Comparative genomics and correlative omics are a fast and efficient method for linking bioactive but genetically orphan natural products to their biosyntheti...
Characterizing the performance of an antibiotic resistance prediction tool, gnomonicus, using a diverse test set of 2,663 Mycobacterium tuberculosis samples [0.03%]
通过一组多样化的2663份结核分枝杆菌样本测试抗生素抗性预测工具gnomonicus的性能特征
Jeremy Westhead,Catriona S Baker,Marc Brouard et al.
Jeremy Westhead et al.
Tuberculosis remains a global health problem. Making it easier and quicker to identify which antibiotics an infection is likely to be susceptible to will be a key part of the solution. Whilst whole-genome sequencing offers many advantages, ...
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance [0.03%]
非洲霍乱弧菌分离株的基因组多样性和抗微生物耐药性：PulseNet Africa倡议使用纳米孔测序增强基因组监测的一项研究
Ebenezer Foster-Nyarko,Shola Able-Thomas,Nana Eghele Adade et al.
Ebenezer Foster-Nyarko et al.
Objectives. Vibrio cholerae remains a significant public health threat in Africa, with antimicrobial resistance (AMR) complicating treatment. This study leverages whole-genome sequencing (WGS) of V. cholerae isolates from Côte d'Ivoire, Gh...
Early-life infection dynamics and genomic diversity of adenoviruses in a wild primate (Theropithecus gelada) [0.03%]
早期感染动态和基因组多样性的腺病毒在野生灵长类动物（Theropithecus gelada）中的研究
Maya J Saroff,Abebaw Azanaw Haile,Alice Baniel et al.
Maya J Saroff et al.
In humans, adenoviruses (AdVs) are frequently associated with respiratory illnesses, posing risks to children with developing immune systems and immunocompromised individuals. Outbreaks and epidemics are generally centred in close-contact s...
Epidemiological dynamics of Leishmania (Sauroleishmania) tarentolae and Trypanosoma platydactyli in reptile hosts and sand flies: from isolation to genome assembly [0.03%]
沙蛇马杜里弧菌和短指蝙蝠布拉第伊氏采微虫在爬行动物宿主和白蛉中的流行病学动力学：从分离培养到基因组测序组装
Livia Perles,Jairo Alfonso Mendoza-Roldan,Marcos Antonio Bezerra-Santos et al.
Livia Perles et al.
Leishmania (Sauroleishmania) tarentolae and Trypanosoma platydactyli are reptile-associated trypanosomatids transmitted by Sergentomyia minuta sand flies, posing challenges for accurate diagnosis due to the fact that they often occur in sym...
Identification of genetic determinants that drive population differentiation and host adaptation in Campylobacter jejuni in California [0.03%]
在加利福尼亚州鉴定驱动Campylobacter jejuni种群分化和宿主适应的遗传决定因素
Evangelos A Dimopoulos,Caitlin E F Collins,Maliha Aziz et al.
Evangelos A Dimopoulos et al.
Campylobacter jejuni is a commensal bacterium that colonizes livestock and wild animals and is responsible for more than 80% of campylobacteriosis cases in humans, which all ultimately have an animal source. Its high genome plasticity and r...