Functional shifts of the dual-substrate phosphoribosyl isomerase PriA from primary to specialized metabolism in rare Actinomycetota [0.03%]
罕见放线菌门中双底物磷酸核糖异构酶PriA从初级代谢向专业代谢的功能转移
Luis Rodrigo Rosas-Becerra,Andrés Arredondo-Cruz,Nelly Sélem-Mojica et al.
Luis Rodrigo Rosas-Becerra et al.
Evolutionary functional innovations can occur while gene families expand and two homologous (or analogous) genes co-occur. PriA is a dual-substrate enzyme family exclusive to Actinomycetota, with activities in l-histidine and l-tryptophan b...
The novel pseudo-compound transposon Tn 7086 carries aminoglycoside resistance genes in Enterococcus faecalis [0.03%]
新的假复合转座子Tn7086含有耐氨基糖苷类基因并存在于粪链球菌中
Lorenzo Colombini,Mariana Tirziu,Stefano De Giorgi et al.
Lorenzo Colombini et al.
Enterococcus faecalis is a member of the human gut microbiota and a pathogen responsible for mild and severe infections. Here, genome analysis of E. faecalis strains isolated from different body sites revealed the presence of a novel family...
Lifestyle-associated variation in type IV secretion systems between phytopathogenic and environmental Ralstonia [0.03%]
植物致病性和环境条件下的Ralstonia菌群中IV型分泌系统的差异性分析
Tabitha C Cowell,Matthew L Cope-Arguello,Gi Yoon Shin et al.
Tabitha C Cowell et al.
Type IV secretion systems (T4SSs) are versatile machines with variable functions including DNA uptake and release, protein translocation, and DNA conjugation. However, the diversity, distribution, and functional roles of the T4SS in the Ral...
Systematic characterization of PBP2 as the primary siderophore recognizer in Actinomycetes and other Gram-positive bacteria [0.03%]
系统表征PBPs在放线菌和其他革兰氏阳性菌中作为主要铁载体受体的作用
Linlong Yu,Guanyue Xiong,Zhiyuan Li
Linlong Yu
Iron is a scarce yet essential nutrient for bacteria. Microbes often acquire iron by secreting siderophores, a diverse group of small molecules that form high-affinity complexes with iron for microbial uptake. Understanding microbial iron i...
Temporal genomic dynamics of sequence type 39 Klebsiella pneumoniae in a neonatal unit in Blantyre, Malawi [0.03%]
马拉维布兰太尔一家新生儿病房中序列类型39肺炎克雷伯菌的动态基因组时间变化规律
Allan M Zuza,Oliver Pearse,Daryl B Domman et al.
Allan M Zuza et al.
Background . Klebsiella pneumoniae (Kpn) is an important cause of healthcare-associated infections (HAIs). In low- and middle-income countries, HAI due to Kpn disproportionately affects neonates. In this study, we investigated the genomic c...
Comparative genomics of a poinsettia-associated phytoplasma and functional validation of its SAP11-homologous effectors that induce plant branching [0.03%]
一枝黄花棒状杆菌的比较基因组学及分支诱导效应蛋白的功能验证
Shen-Chian Pei,Nian-Pu Li,Ting-Ting Li et al.
Shen-Chian Pei et al.
Phytoplasmas are insect-transmitted plant pathogens that manipulate host development through secreted effector proteins. While they are notorious for causing agricultural losses, in the ornamental plant poinsettia (Euphorbia pulcherrima), p...
Nanopore sequencing enables highly accurate genotyping and identification of resistance determinants in key nosocomial pathogens [0.03%]
纳米孔测序能够对主要的医院感染病原体进行高精度基因分型和耐药决定簇鉴定
Hugh Cottingham,Louise M Judd,Taylor Harshegyi-Hand et al.
Hugh Cottingham et al.
Whole-genome sequencing of bacterial pathogens can positively impact infectious disease management in clinical contexts, both in individual settings and by assisting infection prevention efforts. However, logistical issues have often preven...
Population genomic variation in Staphylococcus aureus isolates from carriage and disease in Indigenous communities in the Southwest United States [0.03%]
美国西南部原住民社区中携带和患病的金黄色葡萄球菌分离株的群体基因组变异
Eleonora Cella,Catherine G Sutcliffe,Del Yazzie et al.
Eleonora Cella et al.
Indigenous populations in the USA experience disproportionately high rates of Staphylococcus aureus invasive disease, yet the drivers of this disparity remain unclear. To investigate the role of bacterial population structure, we conducted ...
Diverse genomic landscape of swine influenza A virus in England (2014-2021) [0.03%]
英格兰（2014-2021）猪流感病毒的多样化基因组景观
Benjamin C Mollett,Alexander Mp Byrne,Helen E Everett et al.
Benjamin C Mollett et al.
Surveillance of swine influenza A viruses (SwIAVs) in pigs is critical for identification of novel genetic groups that pose a risk to pig health and might have zoonotic potential. SwIAVs circulating in pigs in England between 2014 and 2021 ...
Phylodynamic analysis of Salmonella Enteritidis ST183 in Aotearoa New Zealand finds no evidence for introduction via European hedgehogs (Erinaceus europaeus) [0.03%]
在奥塔哥新西兰对沙门氏菌伤寒菌株ST183的谱系动态分析未能发现通过欧洲刺猬（ Erinaceus europaeus）引入的证据
Hugo Strydom,Shevaun Paine,David Welch et al.
Hugo Strydom et al.
Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) is the second most common serovar causing human salmonellosis in Aotearoa New Zealand (NZ). Sequence type (ST)183, which includes phage types 9a and 11, was the second...