Exosome injection as a prevention strategy for early postoperative mesh complications in a porcine model of sacrocolpopexy [0.03%]
腹腔镜骶棘筋膜悬吊术猪模型早期网片并发症的外泌体干预研究
Cassandra K Kisby,Sam Faraguna,Abigail Hitt et al.
Cassandra K Kisby et al.
Exosomes, an acellular regenerative biologic, have demonstrated success in resolving vaginal mesh exposures after pelvic reconstructive surgery; little data exists for their use for prevention of mesh-based complications. This study evaluat...
Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing [0.03%]
具有时空控制的生长因子递送和环糊精增强的生长因子受体隔离拮抗作用的支架促进皮肤伤口愈合
Jelena Marjanovic,Veronika Jurczuk,Lilian Valadares Tose et al.
Jelena Marjanovic et al.
Chronic wounds present a major burden to patients, health care professionals, and health care systems worldwide, yet treatment options remain limited and often ineffective. Although initially promising, growth factor-based therapies display...
Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts [0.03%]
巨噬细胞的V型胶原蛋白在心肌梗死后调节初始胶原蛋白装配和排列
Xin Sun,Sarah Sigal,Maria-Alexa Cosma et al.
Xin Sun et al.
Previous work has revealed that macrophages directly contribute collagen to the fibrotic scar in the injured hearts of zebrafish and mice. However, the functional impact of this contribution has not been investigated. Here, we characterised...
Deconstruction of cellular dynamics after treatment of volumetric muscle loss injury with extracellular matrix [0.03%]
用于治疗体积性肌肉损失损伤的细胞外基质治疗后的细胞解构及动态变化分析研究
Adrienne A Giannone,Shanae A-M Butler,Jacqueline A Larouche et al.
Adrienne A Giannone et al.
The acute loss of critical skeletal muscle volume or volumetric muscle loss (VML) results in persistent inflammation, fibrotic scarring, permanent strength deficits and long-term disability. The molecular mechanisms that drive fibrosis foll...
Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing [0.03%]
人多能诱导干细胞来源的间充质干细胞促进皮肤再生和烧伤创面愈合
Mahmoud Farahat,Sophie Brosset,Yufei Chen et al.
Mahmoud Farahat et al.
The key to surviving severe burns is rapid burn wound excision and closure, yet extensive wounds often surpass natural healing capacity. Alternative treatments, such as synthetic skin substitutes, have not emerged as a standard, optimal sol...
FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids [0.03%]
FGF9治疗可减少由多能干细胞衍生的肾脏类器官中的脱靶软骨细胞
Virginie Joris,Anika Schumacher,Maria Paula Marks et al.
Virginie Joris et al.
Renal failure due to drug nephrotoxicity or disease is frequently observed in patients. The development of in vitro models able to recapitulate kidney biology offers new possibilities to study drug toxicity or model diseases. Induced plurip...
Desmoglein-driven dynamic signaling in pemphigus vulgaris: a systematic review of pathogenic pathways [0.03%]
天疱疮中由脱细胞间质蛋白引起的作用动力学信号传导：病理途径的系统综述
Siavash Rahimi,William V J Hariton,Fattaneh Khalaj et al.
Siavash Rahimi et al.
Epithelial tissue integrity is maintained through specialized intercellular junctions known to coordinate homeostatic processes. In this context, outside-in signaling and mechanotransduction through desmosomal cadherins, the building blocks...
Prx1+ progenitors give rise to new articular cartilage when conditions are permissive for endogenous regeneration [0.03%]
允许内源性再生的条件下Prx1+祖细胞可分化生成新的关节软骨
Christina L Jablonski,Dora Modrcin,John Cobb et al.
Christina L Jablonski et al.
It is widely acknowledged that articular cartilage lacks the ability to regenerate. However, if such regeneration were possible, which cell type would generate new tissue? The p21-/- mouse provides an excellent platform to explore this ques...
Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons [0.03%]
超分子纳米结构模仿GDNF在体外对人多巴胺能神经元的营养作用
Oscar A Carballo-Molina,Alexandra N Kolberg-Edelbrock,Matías Alvarez-Saavedra et al.
Oscar A Carballo-Molina et al.
Peptide-based supramolecular nanostructures offer a versatile platform with substantial promise for clinical translation in regenerative medicine. These systems allow for the incorporation of biologically active sequences and can be enginee...
Yuval Rinkevich,Baruch Rinkevich
Yuval Rinkevich
Tissue and organ regeneration are common among aquatic invertebrates, yet these taxa and their potential as model organisms remain underexplored. We present evidence of extensive regenerative capabilities in aquatic invertebrates, highlight...