Therapeutic-delivering endotracheal tubes heal intubation injury via mucosal remodeling and disrupting the inflammation-microbiome-fibrosis triad [0.03%]
具有递送药物能力的气管插管可通过粘膜重塑并破坏炎症-微生物群-纤维化三联征来治愈插管损伤
Gabriela Gonzales,Ronit Malka,Solaleh Miar et al.
Gabriela Gonzales et al.
Endotracheal intubation is essential in clinical care but often exacerbates airway inflammation, fibrosis, and microbial dysbiosis, contributing to long-term complications. This study investigates how newly developed, coated endotracheal tu...
HGF mRNA LNP therapy promotes uterine repair after cesarean section in a mouse model [0.03%]
HGF mRNA LNP疗法促进小鼠剖宫产术后子宫修复
Xue-Ning Li,Wei-Jing Kong,Jia-Xin Li et al.
Xue-Ning Li et al.
Previous cesarean scar defect (PCSD) is the most common complication following cesarean delivery, characterized by myometrial thinning or disruption. Its incidence rises with increasing number of cesarean sections, reaching 76% after three ...
Prophylactic inhibition of LATS1/2 before high-dose irradiation promotes the regeneration of the damaged intestinal epithelium [0.03%]
高剂量照射前抑制LATS1/2促进损伤小肠上皮的再生
Lucy M Driver,Frances Anne Tosto,Bridget S Scherer et al.
Lucy M Driver et al.
Following radiation injury, intestinal epithelial cells adapt through cellular plasticity to regenerate and repopulate the damaged epithelium by activating Yap, a key effector protein of the Hippo signaling pathway. However, the impact of p...
Gli2-serpinh1 drives fibroblast state transition during skin wound healing [0.03%]
Gli2-serpinh1在皮肤伤口愈合过程中的成纤维细胞状态转换中起作用
Rui Ma,Wang Wu,Chuqing Zhou et al.
Rui Ma et al.
Dermal fibroblasts exhibit spatiotemporal heterogeneity, transitioning from coordinating immune signaling and depositing a provisional extracellular matrix during the early inflammatory phase to driving directional migration and mature matr...
Tie2-enriched nucleus pulposus cell transplantation enables severity-independent disc repair in a canine model with induced and controlled disc degeneration severity [0.03%]
富TIE2核盘细胞移植可在诱导和控制椎间盘退变程度的犬模型中实现不受严重程度影响的椎间盘修复
Jordy Schol,Takayuki Warita,Erika Matsushita et al.
Jordy Schol et al.
Intervertebral disc (IVD) degeneration is characterized by extracellular matrix loss, impaired nucleus pulposus cell (NPC) function, and depletion of Tie2-positive NP progenitor cells, leading to progressive structural failure and potential...
Lumican deficiency dysregulates trophoblast function via PI3K/AKT and P53 signaling in preeclampsia [0.03%]
胶原蛋白硫酸酯酶LUMICAN通过PI3K/AKT和P53信号通路调控子痫前期滋养细胞功能失调
Xin Wang,Qi Zhang,Yi Ren et al.
Xin Wang et al.
Lumican, an extracellular matrix (ECM) component highly expressed in placenta, is implicated in preeclampsia (PE) pathogenesis, though its precise mechanisms in trophoblast function and PE development remain unclear. Transcriptomic analysis...
TGF-alpha/EGFR signalling mediates retinoic acid-induced lung repair [0.03%]
转化生长因子-α和表皮生长因子介导了视黄酸引起的肺修复作用
Sek-Shir Cheong,Chunyu Yan,Róisín Mongey et al.
Sek-Shir Cheong et al.
Lung repair involves coordination of multicellular processes, including endothelial angiogenesis and epithelial repopulation. Retinoic acid (RA) signalling is crucial for lung development, homeostasis, and repair; however, the mechanisms th...
Multi-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy [0.03%]
多组学谱型分析揭示了通过清除衰老细胞的疗法可使系统性衰老肾脏恢复活力
Shilin Chen,Chenglin Zhang,Pengxu Cang et al.
Shilin Chen et al.
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D + Q) has shown promise in mitigating ag...
isl1a coordinates onset and termination of regeneration of the zebrafish lateral line [0.03%]
Isl1a调节斑马鱼侧线再生的启动和终止
Paloma Meneses-Giles,Kaelan J Brennan,Nhung T T Tran et al.
Paloma Meneses-Giles et al.
Regenerative capacity varies widely across tissues and species. Most regeneration studies have focused on identifying genes and pathways that promote regeneration, whereas mechanisms that inhibit regeneration to enforce organ size control a...
Comparison of cardiac regeneration capacity between zebrafish and medaka reveals a regenerative response in both teleost species [0.03%]
斑马鱼和鲤鱼心脏再生能力的比较揭示了两种鱼类都具有再生能力
Miguel Angel Garitagoitia-Romero,María Galardi-Castilla,Miguel Torres et al.
Miguel Angel Garitagoitia-Romero et al.
Danio rerio (zebrafish) can regenerate their heart upon loss of over 20% of the total myocardium. A second teleost species, Oryzias latipes (medaka), however, has been described to lack this capacity and respond to a lesion forming a perman...