Yining Pan,Hwayoung Cho,Qian Lou et al.
Yining Pan et al.
Alzheimer's disease (AD) has a strong genetic predisposition. Genome-wide association studies have identified multiple risk loci, yet many non-coding variants remain uncharacterized. Machine learning-based polygenic risk scores (PRS) enhanc...
Optimal control theory as a method for designing multidrug adaptive therapy regimens [0.03%]
最优控制理论在设计多药自适应治疗方案中的应用方法研究
Afton Widdershins,Elsa Hansen,Andrew Read et al.
Afton Widdershins et al.
Evolutionarily informed regimens offer new approaches that hope to combat the development of resistance during cancer treatment. These regimens are often complicated to design. In this work, we use optimal control theory (OCT) to guide the ...
Axel von Kamp
Axel von Kamp
Until Charles Darwin published his book on earthworms in 1881, their role in the soil was largely unclear. By now, the importance of earthworms for soil fertility has been recognized and their phenomenology is being studied for various purp...
Michael Lauber,Markus List
Michael Lauber
Direct cellular reprogramming, converting one differentiated cell type directly into another, holds immense promise for regenerative medicine, developmental biology, and disease modeling. Identifying optimal transcription factor (TF) combin...
Exploring CHO cell stability during prolonged passaging via eXplainable AI driven flux balance analysis [0.03%]
基于可解释人工智能驱动的通量平衡分析探索长时间传代过程中CHO细胞的稳定性
Dong-Hyuk Choi,Sun-Jong Kim,Jinsung Song et al.
Dong-Hyuk Choi et al.
Production stability remains a major challenge in Chinese hamster ovary (CHO) cell-based therapeutic protein manufacturing, particularly during extended passaging where the underlying mechanisms of instability are not fully understood. Thus...
Development of a severe rat refeeding syndrome model and mathematical modeling of the associated hypophosphatemia [0.03%]
大鼠严重再喂养综合症模型的建立及低磷血症的相关数学建模研究
Hiroaki Kato,Ippei Yamaoka,Hiroyuki Kubota
Hiroaki Kato
Refeeding syndrome (RFS) is a life-threatening metabolic complication caused by refeeding in malnourished patients and is a barrier to early nutritional supplementation. Hypophosphatemia is a hallmark of RFS; however, its detailed pathogeni...
Simulation-based inference of cell migration dynamics in complex spatial environments [0.03%]
基于模拟的复杂空间环境下的细胞迁移动力学的推理
Jonas Arruda,Emad Alamoudi,Robert Mueller et al.
Jonas Arruda et al.
To assess cell migration in complex spatial environments, microfabricated chips, such as mazes and pillar forests, are routinely used to impose spatial and mechanical constraints, and cell trajectories are followed within these structures b...
Dynamical network analysis reveals long-range residue couplings at the pMHC interface underlying enhanced immunogenicity [0.03%]
动态网络分析揭示了pMHC界面上的基本相互作用残基耦合，解释了增强的免疫原性现象
Tom Resink,Benedetta Maria Sala,Renhua Sun et al.
Tom Resink et al.
The interaction between a class I peptide-major histocompatibility complex (pMHC) and a T cell receptor (TCR) plays a central role in the elicitation of CD8+ T cell immune responses. As a result, considerable effort has been invested in und...
Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer [0.03%]
空间FBA揭示了肾肿瘤中的异质性瓦堡生态位和结直肠癌中的乳酸消耗
Davide Maspero,Giovanni Marteletto,Francesco Lapi et al.
Davide Maspero et al.
To investigate how spatial constraints shape cancer metabolism, we devised the spatial Flux Balance Analysis (spFBA) framework for the enrichment of spatial transcriptomics data with relative estimates of metabolic fluxes. Applying spFBA to...
Russell C Rockne,Morten Andersen,Alexander R A Anderson et al.
Russell C Rockne et al.
This perspective article discusses emerging advances at the interface of mechanistic modeling and data-driven machine learning, highlighting opportunities for AI to accelerate discovery, improve predictive modeling, and enhance clinical dec...