Thi Trang Nguyen,Yudi Pawitan,Stefano Calza et al.
Thi Trang Nguyen et al.
Drug repurposing (DR) has gained significant attention as a cost-effective strategy for identifying new therapeutic uses for existing drugs. Heterogeneous network-based methods are particularly promising because they exploit complex biologi...
Kaichao Wu,Beth Jelfs,Qiang Fang et al.
Kaichao Wu et al.
Stroke disrupts brain function beyond focal lesions, altering multiscale temporal dynamics essential for information processing. We investigated intrinsic neural timescales (INT) and other properties of long-range temporal correlations, usi...
Deciphering cell-fate trajectories using spatiotemporal single-cell transcriptomic data [0.03%]
利用时空单细胞转录组数据解码细胞命运轨迹
Zhenyi Zhang,Zihan Wang,Yuhao Sun et al.
Zhenyi Zhang et al.
Cellular processes evolve dynamically across time and space. Single-cell and spatial omics technologies have provided high-resolution snapshots of gene expression, greatly expanding the capability to characterize cellular states. This revie...
Mammalian synthetic gene circuits for biopharmaceutical development & manufacture [0.03%]
哺乳动物合成基因线路在生物制药开发和生产中的应用
Sheryl Li Yan Lim,Sofia Gialamoidou,Rajinder Kaur et al.
Sheryl Li Yan Lim et al.
This paper reviews the design and application of mammalian synthetic gene circuits for biopharmaceutical manufacturing. It discusses key design principles and outlines transcription factors, DNA-binding proteins, and RNA as input and regula...
Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation [0.03%]
低温通过霍普夫分岔消灭人类细胞昼夜节律
Yaoyao Xiao,Yuko Sainoo,Takayuki Nishimura et al.
Yaoyao Xiao et al.
Circadian clocks orchestrate behavior, physiology, and metabolism in harmony with the Earth's 24-h cycle. Low temperatures are known to disrupt circadian clocks in plants and poikilotherms; however, their effects on human circadian rhythms ...
A strategic approach to multi-omics literature retrieval in next generation mammalian cell bioprocessing [0.03%]
新一代哺乳动物细胞生物工艺中的多组学文献检索的战略方法
Eva Price,Duygu Dikicioglu
Eva Price
Scientific literature is being published at an exponential rate, including in the field of mammalian cell bioprocessing. At the same time, the research landscape is becoming more diverse, with the emergence of multiple specialised subfields...
Hif-1 responsive IFFLs to explain specific transcriptional responses to cycling hypoxia in cancers [0.03%]
低氧诱导因子-1反应式IFFL解释癌症中循环低氧的特异性转录反应
Xihua Qiu,Yamin Liu,Paola Vera-Licona et al.
Xihua Qiu et al.
The adaptive response of cancer cells to hypoxia, a key microenvironmental factor in solid tumors, is orchestrated by Hypoxia-inducible factor 1 (HIF-1). Recent evidence indicate that oxygen tension in tumor is dynamic, with hypoxia being f...
Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia [0.03%]
ATM信号转导的计算模型在共济失调毛细血管扩张病再利用药物预测中的应用
Aurora Eliana Merulla,Valentina Di Salvatore,Giorgia Serena Gullotta et al.
Aurora Eliana Merulla et al.
Ataxia-Telangiectasia (A-T) is a rare genetic disorder caused by ATM mutations, leading to impaired DNA repair, oxidative stress, and neurodegeneration. We developed a computational model of ATM-mediated signaling using ordinary differentia...
NF-κB epigenetic attractor landscape drives breast cancer heterogeneity [0.03%]
NF-κB表观遗传吸引子景观驱动乳腺肿瘤异质性
Francisco Lopes,Bruno R B Pires,Alexandre A B Lima et al.
Francisco Lopes et al.
Heterogeneity in breast cancer (BC) subtypes within a tumor contributes to therapy resistance and cancer recurrence. Subtype heterogeneity in tumors arises through a combination of stochastic genetic/epigenetic changes, phenotypic plasticit...
Integrative gene-metabolite network analysis of GLP-1 receptor agonists and related incretin pathways in cardiometabolic health [0.03%]
GLP-1受体激动剂及其相关肠泌素通路在心代谢健康中的基因-代谢网络整合分析
Zofia Wicik,Anna Nowak-Szwed,Ceren Eyileten et al.
Zofia Wicik et al.
Glucagon-like peptide-1 (GLP-1) is a hormone known for its critical functions in managing blood sugar and offering cardiovascular benefits. Our study focuses on Glucagon Like Peptide 1 Receptor (GLP1R) agonists that act beyond glycemic cont...