A minimal mechanically consistent model of smoothly dividing disk-shaped cells [0.03%]
光滑分裂盘状细胞的最小机械一致性模型
Lukas Hupe,Yoav G Pollack,Jonas Isensee et al.
Lukas Hupe et al.
Replication through cell division is one of the fundamental processes of life and a major driver of dynamics in systems ranging from bacterial colonies to embryogenesis, tissues and tumors. While regulation also shapes self-organization, ma...
Maria Abou Chakra,Nika Shakiba
Maria Abou Chakra
Human development begins with a zygote, yet how this cell forms complex tissues remains a mystery. Progress has been limited by ethical constraints and scarce biological materials. Advances in stem-cell models and virtual twins are now tran...
Characterizing open-ended evolution through undecidability mechanisms in random Boolean networks [0.03%]
通过随机布尔网络中的不可判定机制来表征开放终结进化
Amahury J López-Díaz,Pedro Juan Rivera Torres,Gerardo L Febres et al.
Amahury J López-Díaz et al.
Discrete dynamical models underpin systems biology, but we still lack substrate-agnostic diagnostics for identifying finite-horizon dynamical signatures that may be relevant to open-ended evolution (OEE), such as the recurrent production of...
Resveratrol alleviates intervertebral disc degeneration by regulating ferroptosis of nucleus pulposus cells [0.03%]
白藜芦醇通过调节髓核细胞铁死亡的进程来缓解椎间盘退行性疾病的研究
Xiaoqiang Wang,Jiale Lv,Daqian Zhou et al.
Xiaoqiang Wang et al.
Intervertebral disc degeneration (IVDD) is a major contributor to chronic low back pain, yet its molecular mechanisms remain incompletely understood. Emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell deat...
In silico models in oncology, neurology, and epidemiology: systems-level and multiscale perspectives [0.03%]
肿瘤学、神经病学和流行病学的计算机模型：系统级和多尺度视角
Matteo Italia,José Garcia Otero,Juan Jiménez-Sánchez et al.
Matteo Italia et al.
Computational medicine uses mathematical modelling, high-performance computing, and the availability of large-scale biomedical data to study multiscale complex diseases. This review synthesises recent developments in in silico oncology, neu...
Abhishek Sengupta,Vishal Singh,Muskan Syed et al.
Abhishek Sengupta et al.
Vitiligo is a multifaceted autoimmune skin disease characterized by the loss of epidermal melanocytes, yet its molecular basis remains poorly understood. To address the need for a specialized systems biology interface, we present VIRdb v3.0...
Molecular noise modulates transitions in the cell-fate differentiation landscape [0.03%]
分子噪声调节细胞分化命运景观中的转换事件
Yujing Liu,Adriana Zanca,Michael P H Stumpf et al.
Yujing Liu et al.
Waddington's epigenetic landscape has become one of biology's cornerstone metaphors, widely used both conceptually and computationally. Cell types are often associated with the qualitatively stable points or valleys of this landscape. In pr...
Pathway-centric visualization of cell-cell communication in single-cell transcriptomics data [0.03%]
单细胞转录组学数据中基于信号通路的细胞间通讯可视化技术
Sidrah Maryam,Martin Manolov,Rafael Kramann et al.
Sidrah Maryam et al.
Single-nuclei transcriptomics enables investigating ligand-receptor mediated cell-cell communication between different cell-types. However, current tools do not allow for non-programmatic means to access this analysis. Additionally, most me...
Growth rate-dependent mutations and phenotypic switching facilitate rapid adaptation [0.03%]
依赖增长速率的突变和表型转换可促进快速适应性进化
Anton Grishechkin,Omer Karin
Anton Grishechkin
The mutation rates of many species are regulated in response to internal and external conditions. Studies in several model organisms have shown that mutation rates can be modulated by the organism's growth rate, particularly through stress-...
Intelligent tool orchestration for rapid mechanistic model prototyping: MCP servers as AI-biology interfaces [0.03%]
智能工具编排在机制模型原型设计中的应用：利用MCP服务器作为AI与生物接口进行快速假设验证
Marco Ruscone,Miguel Vazquez,Alfonso Valencia
Marco Ruscone
Constructing multicellular mechanistic models traditionally requires extensive time and computational expertise. We introduce intelligent tool orchestration via Model Context Protocol (MCP) servers, enabling Large Language Model (LLM) agent...